climbing a flight of stairs (pZ0.004), and more shortness of breath when sitting (p<0.001), walking one block (pZ0.007), and going up a flight of stairs (pZ0.03) compared to those who received SURG. Conclusion: SEER-MHOS database provides useful information for patient-reported outcomes in patients receiving definitive therapy for early stage lung cancer. Compared to SURG, patients older than 65 who received RT had lower PSC scores and more difficulty with SOB, secondary to poorer performance status at baseline vs. treatment effects. Limitations include low number of patients receiving RT, lack of information of the type of RT or SURG received, and lack of direct comparison between individual patients pre-and post-diagnosis.

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fractions. All institutions customized their lung blocks however the thickness varied to provide 50 to 70% transmission. 67% specified mid lung dose whereas 37% did not specify lung dose for lateral TBI. Of the 67% who specified mid lung dose, only 33% used CT or 2D imaging to estimate the mid lung dose. No CT planning was done for lateral TBI. 100% of the physician responders answered "yes" to redefining current TBI techniques and > 75% supported the investigation of new TBI techniques in an effort to lower the lung doses. Conclusion: The practice of TBI amongst COG institutions is very heterogeneous. Dose accuracy is difficult to assess as few perform CT-based planning. These findings warrant caution to be exercised when interpreting radiation related efficacies and toxicities when multi-institutional clinical studies are carried out. COG is currently undertaking steps to standardize the practice of TBI.

partial cystectomy. Pathology revealed mature rhabdomyoblasts or cystitis cystica. Postoperatively, 4 of the 7 experienced grade 3 bladder toxicity, including prolonged hematuria, cystitis, and dysuria. Two of the 6 who underwent biopsy have nocturnal enuresis at age 7 and 9 years, compared to 0 of the 7 in the non-pseudoprogression cohort. Conclusion: In children undergoing proton therapy for unresectable pelvic rhabdomyosarcoma, pseudoprogression is common. Unnecessary intervention may result in more bladder toxicity than chemoradiotherapy itself.

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