Testosterone-sensitive vasotocin-immunoreactive cells and fibers in the canary brain

Voorhuis, Th.A.M.; Kiss, József Zoltán; Kloet, E. Ronald de; Wied, D. de

doi:10.1016/0006-8993(88)91441-2

Cited by 90 publications

(61 citation statements)

References 33 publications

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“…However, many related species such as the bobwhite quail (Colinus virginianus) are broadly distributed and could potentially serve the same role as Japanese quail in the wild. We already know that the activational effects of steroids on the brain VT system that have been described here also occur in other avian species, such as the domestic chicken (76), and several passerine species such as the junco and the canary (6,38). Biological markers of estrogenic exposure are therefore already present in the wild, and introducing quail is not necessary to have a constant monitoring of these compounds.…”

Section: Discussionmentioning

confidence: 52%

“…In canaries, treatment of females with T enhances the VT immunoreactivity in the lateral septum to a male-typical level (6). This suggests that the sex dimorphism observed in adult birds reflects only a differential activation by T in males and females.…”

Section: Effects Of Gonadal Steroids In Adult Birdsmentioning

confidence: 94%

“…In galliforms, immunocytochemical studies showed that VT-ir neurons are present in the BSTm of males only and cannot be visualized in females (10,11). In the canary this difference is less extreme, and both sexes have VT-ir neurons in the BSTm, but they are present in larger numbers in males than in females (6,13). In contrast, no sexual dimorphism was observed at this level in another oscine species, the zebra finch (7).…”

Section: Sex Dimorphism Of the Vasotocin System In The Avian Brainmentioning

confidence: 99%

“…One group is located in the mesencephalon around the nucleus rotundus (3,4), and another group containing a larger number of neurons is present within the medial part of the avian nucleus of the stria terminalis (BSTm) (Figure 1). This latter group was first identified in oscine birds (5)(6)(7)(8) and later in galliforms (4,(9)(10)(11).…”

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confidence: 94%

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The parvocellular vasotocin system of Japanese quail: a developmental and adult model for the study of influences of gonadal hormones on sexually differentiated and behaviorally relevant neural circuits.

Panzica

Balthazart

Pessatti³

et al. 2002

Environ Health Perspect

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Vasotocin (VT; the antidiuretic hormone of birds) is synthesized by diencephalic magnocellular neurons projecting to the neurohypophysis. A sexually dimorphic system of VT-immunoreactive (ir) parvocellular elements has been described within the male medial preoptic nucleus (POM) and the nucleus of the stria terminalis, pars medialis (BSTm). VT-ir fibers are present in many diencephalic and extradiencephalic locations, and quantitative morphometric analyses demonstrated their sexually dimorphic distribution in regions involved in the control of different aspects of reproduction. Moreover, systemic or intracerebroventricular injections of VT markedly inhibit the expression of some aspects of male sexual behavior. In adult animals, circulating levels of testosterone (T) have a profound influence on the VT immunoreactivity within BSTm, POM, and lateral septum. Castration markedly decreases the immunoreaction, whereas T-replacement therapy restores a situation similar to the intact birds. We observed no changes in gonadectomized females treated with T. These changes parallel similar changes in male copulatory behavior (not present in castrated male quail, fully expressed in castrated, T-treated males). The restoration by T of the VT immunoreactivity in castrated male quail could be fully mimicked by a treatment with estradiol (E(2)), suggesting that the aromatization of T into E(2) may play a key limiting role in both the activation of male sexual behavior and the induction of VT synthesis. This dimorphism has an organizational nature: administration of E(2) to quail embryos (a treatment that abolishes male sexual behavior) results in a dramatic decrease of the VT immunoreactivity in sexually dimorphic regions. Conversely, the inhibition of E(2) synthesis during embryonic life (a treatment that stimulates the expression of male copulatory behavior in treated females exposed in adulthood to T) results in a malelike distribution of VT immunoreactivity. The VT parvocellular system of the Japanese quail can therefore be considered an accurate marker of the sexual differentiation of brain circuits mediating copulatory behavior and could be a very sensitive indicator of the activity of estrogenlike substances on neural circuits.

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Section: Discussionmentioning

confidence: 52%

Section: Effects Of Gonadal Steroids In Adult Birdsmentioning

confidence: 94%

Section: Sex Dimorphism Of the Vasotocin System In The Avian Brainmentioning

confidence: 99%

mentioning

confidence: 94%

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The parvocellular vasotocin system of Japanese quail: a developmental and adult model for the study of influences of gonadal hormones on sexually differentiated and behaviorally relevant neural circuits.

Panzica

Balthazart

Pessatti³

et al. 2002

Environ Health Perspect

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“…They have been found not only in various rodent species [European (Buijs et al 1986) and Djungarian hamsters (Bittman et al 1991), Mongolian gerbils (Crenshaw et al 1992), prairie and meadow voles (Bamshad et al 1993), and mice (Mayes et al 1988 rough-skinned newts (Moore 1992) and bullfrogs (Boyd et al 1992); reptiles: the lizards Gekko gecko (Stoll and Voom 1985) and Anolis carolinensis (Propper et al 1992), the turtle Pseudemys scripta elegans, and the snake Python regius (Smeets et al 1990); birds: Japanese quails (Viglietti-Panzica et al 1992) and canaries (Voorhuis et al 1988 )]. There are, however, animals with homologous vasotocin-ir or vasopressin-ir projections that are not notably sexually dimorphic [rainbow trouts (Van Den Dungen et al 1982), the amphibians Rana ridibunda, Xenopus-laevis, and Pleurodeles waltii (Gonzales and Smeets 1992a,b), and guinea pigs (Dubois-Dauphin et al 1989)].…”

Section: Homologous Sex Differences In Other Vertebratesmentioning

confidence: 99%

Studying neurotransmitter systems to understand the development and function of sex differences in the brain: the case of vasopressin

Vries¹,

Geert²

1995

Neurobiological Effects of Sex Steroid Hormones

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Neuroanatomical distribution of vasotocin in a urodele amphibian (Taricha granulosa) revealed by immunohistochemical and in situ hybridization techniques

et al. 1997

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Immunohistochemical and in situ hybridization techniques were used to investigate the neuroanatomical distribution of arginine vasotocin-like systems in the roughskin newt (Taricha granulosa). Vasotocin-like-immunoreactive neuronal cell bodies were identified that, based on topographical position, most likely, are homologous to groups of vasopressin-immunoreactive neuronal cell bodies described in mammals, including those in the bed nucleus of the stria terminalis, medial amygdala, basal septal region, magnocellular basal forebrain-including the horizontal limb of the diagonal band of Broca, paraventricular and supraoptic nuclei, suprachiasmatic nucleus, and dorsomedial hypothalamic nucleus. Several additional vasotocin-like-immunoreactive cell groups were observed in the forebrain and brainstem regions; these observations are compared with previous studies of vasotocin- and vasopressin-like systems in vertebrates. Arginine vasotocin-like-immunoreactive fibers and presumed terminals also were widely distributed with high densities in the basal limbic forebrain, the ventral preoptic and hypothalamic regions, and the brainstem ventromedial tegmentum. Based on in situ hybridization studies with synthetic oligonucleotide probes for vasotocin and the related neuropeptide mesotocin, as well as double-labeling studies with combined immunohistochemistry and in situ hybridization, we conclude that the vasotocin immunohistochemical procedures used identify vasotocin-like, but not mesotocin-like, elements in the brain of T. granulosa. The distribution of arginine vasotocin-like systems in T. granulosa is greater than the distribution previously reported for any other single vertebrate species; however, it is consistent with an emerging pattern of distribution of vasotocin- and vasopressin-like peptides in vertebrates. Complexity in the vasotocinergic system adds further support to the conclusion that this peptide regulates multiple neurophysiological and neuroendocrinological functions.

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Testosterone-sensitive vasotocin-immunoreactive cells and fibers in the canary brain

Cited by 90 publications

References 33 publications

The parvocellular vasotocin system of Japanese quail: a developmental and adult model for the study of influences of gonadal hormones on sexually differentiated and behaviorally relevant neural circuits.

The parvocellular vasotocin system of Japanese quail: a developmental and adult model for the study of influences of gonadal hormones on sexually differentiated and behaviorally relevant neural circuits.

Studying neurotransmitter systems to understand the development and function of sex differences in the brain: the case of vasopressin

Neuroanatomical distribution of vasotocin in a urodele amphibian (Taricha granulosa) revealed by immunohistochemical and in situ hybridization techniques

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