Testosterone Synthesis, Transport, and Metabolism

Winters, Stephen J.; Clark, Barbara J.

doi:10.1007/978-1-59259-388-0_1

Cited by 5 publications

(2 citation statements)

References 120 publications

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“…47 Sex hormones are host-derived metabolites, and decreased testosterone excretion in feces implied a corresponding high level in the circulation system. 48 The connection between decreased fecal testosterone and promoted bone mass could be acceptable. In previous studies, the ability of gut microbiota influencing the androgen level has also been observed.…”

Section: ■ Discussionmentioning

confidence: 99%

“…Because of the wide expression of estrogen or androgen receptors on the osteoblast surface, sex hormones could bind to their receptor and thus promote proliferation and also inhibit apoptosis of osteoblasts, which eventually facilitate bone mineralization . Sex hormones are host-derived metabolites, and decreased testosterone excretion in feces implied a corresponding high level in the circulation system . The connection between decreased fecal testosterone and promoted bone mass could be acceptable.…”

Section: Discussionmentioning

confidence: 99%

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Konjac Oligosaccharides Modulate the Gut Environment and Promote Bone Health in Calcium-Deficient Mice

Hao

Shang

et al. 2021

J. Agric. Food Chem.

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This study aimed to investigate the beneficial effect of konjac oligosaccharides (KOS) on bone health in calcium-deficient mice. During the experimental period, low-calcium diet-fed mice were administered with calcium chloride to simulate daily calcium supplementation. Meanwhile, different levels of KOS intervened by adding them into the diet. After 8 weeks, the calcium balance status, bone mass parameters, and gut environment modulation were evaluated. The results showed that dietary KOS intervention alleviated the negative calcium balance, significantly promoted the trabecular number and cortical thickness, and remarkably enhanced the skeletal mechanical strength. Moreover, Pearson’s correlation analysis among significantly changed gut microbiota, gut metabolites, and relevant physiological indexes showed that the microbial genera of Lactobacillus, Bifidobacterium, Mucispirillum, Alistipes, and unidentified Clostridia and gut metabolites of kynurenine and testosterone were significantly associated with increased bone mass. These findings provided a new insight into the effect of prebiotics on bone health.

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Section: ■ Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Konjac Oligosaccharides Modulate the Gut Environment and Promote Bone Health in Calcium-Deficient Mice

Hao

Shang

et al. 2021

J. Agric. Food Chem.

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Testosterone treatment in elderly men

Srinivas-Shankar

Sharma

2009

Adv Therapy

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Testosterone has been used in testicular and hypothalamo-pituitary diseases since the 1940s. There is growing interest in the use of testosterone in aging men, and this has stimulated research into the benefits of male hormone replacement. Testosterone treatment of men with hypogonadism might have beneficial effects on body composition, muscle strength, sexual function, and cognition. There are several modes of administration of the male hormone, with injectable testosterone esters and implanted testosterone pellets being the mainstay of treatment until recently. These preparations are increasingly being replaced by transdermal patches, gels, and long-acting parenteral preparations. Testosterone patches and gels are ideally for elderly men. Treatment with the male hormone is relatively safe, if patients are selected appropriately and monitored carefully. The most important adverse effects are on the prostate. In this review, we briefly discuss the indications, contraindications, and benefits of testosterone treatment. Further, we list the adverse effects, advantages, and disadvantages of various testosterone preparations in elderly men.

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Reading Between the Lines

Reusch

2016

Beyond the Bones

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Testosterone Synthesis, Transport, and Metabolism

Cited by 5 publications

References 120 publications

Konjac Oligosaccharides Modulate the Gut Environment and Promote Bone Health in Calcium-Deficient Mice

Konjac Oligosaccharides Modulate the Gut Environment and Promote Bone Health in Calcium-Deficient Mice

Testosterone treatment in elderly men

Reading Between the Lines

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