Konjac Oligosaccharides Modulate the Gut Environment and Promote Bone Health in Calcium-Deficient Mice

Ai, Tingyang; Hao, Lulu; Shang, Liang; Li, Bin; Li, Jing

doi:10.1021/acs.jafc.0c07839

Cited by 19 publications

(23 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Untargeted metabolomics based on HPLC–MS/MS is an efficient tool for probing hundreds of metabolites even in low quantities and has been applied to detect metabolites in fecal samples . By analyzing the HPLC–MS/MS data, we removed the values of the medium components and screened the significant metabolites in each medium (Tables S2–S6).…”

Section: Resultsmentioning

confidence: 99%

“…Untargeted metabolomics based on HPLC−MS/MS is an efficient tool for probing hundreds of metabolites even in low quantities and has been applied to detect metabolites in fecal samples. 39 By analyzing the HPLC− MS/MS data, we removed the values of the medium components and screened the significant metabolites in each medium (Tables S2−S6). HPLC−MS/MS-based metabolomics analysis revealed that the metabolites screened from different media were significantly different, which suggested that various microbial-fermented media greatly affect the metabolic profile of gut microbiota.…”

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Integrative Analysis of the Gut Microbiota and Metabolome for In Vitro Human Gut Fermentation Modeling

Chu

et al. 2021

J. Agric. Food Chem.

View full text Add to dashboard Cite

This study aimed to find the best in vitro fermentation method by integrative analysis of the gut microbiota and metabolome. We selected five different media: brain heart infusion broth, Luria–Bertani broth, Mueller–Hinton broth, anaerobe basal broth, and anaerobic medium base (AMB). After in vitro fermentation, the gut microbiota and metabolites were analyzed at different culture times. The results showed that different culture media have different effects on the bacterial community structure and metabolites. The integrative analysis of gut microbiota and metabolism also proved that AMB medium is effective in keeping a stable bacterial community structure and producing less metabolites and short-chain fatty acids by simulating the nutrient-poor microenvironment in the human gut during in vitro fermentation. Thus, culturing with AMB medium for 48 h is the most suitable in vitro model for human gut microbiota fermentation, which provides an alternative approach for diet and health research.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Integrative Analysis of the Gut Microbiota and Metabolome for In Vitro Human Gut Fermentation Modeling

Chu

et al. 2021

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…94 Konjac oligosaccharide displayed the beneficial effect of prebiotics on bone health: dietary konjac oligosaccharide intervention in low-calciumdiet-fed mice alleviated the negative calcium balance, significantly promoted the cortical thickness and trabecular number, and remarkably enhanced the mechanical strength of the skeleton. 95 On the basis of published data, it can be concluded that KGM, Da-KGM, and degraded KGM derivatives at an appropriate dosage potentially improved health as a result of their colloidal nutritional effect (Figures 3 and 4). However, overconsumption of KGM and degraded KGM derivatives might cause flatulence and even lead to an imbalance of nutrients.…”

Section: Colloidal Nutritionmentioning

confidence: 97%

“…In addition, konjac oligosaccharide attenuated severity of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats as a result of its anti-inflammatory and prebiotic effects . Konjac oligosaccharide displayed the beneficial effect of prebiotics on bone health: dietary konjac oligosaccharide intervention in low-calcium-diet-fed mice alleviated the negative calcium balance, significantly promoted the cortical thickness and trabecular number, and remarkably enhanced the mechanical strength of the skeleton …”

Section: Colloidal Nutritionmentioning

confidence: 99%

Konjac Glucomannan (KGM), Deacetylated KGM (Da-KGM), and Degraded KGM Derivatives: A Special Focus on Colloidal Nutrition

Zongo

Shah

et al. 2021

J. Agric. Food Chem.

Self Cite

View full text Add to dashboard Cite

Konjac flour, mainly obtained and purified from the tubers ofAmorphophallus konjac C. Koch, yields a high molecular weight (M w) and viscous hydrocolloidal polysaccharide: konjac glucomannan (KGM). KGM has been widely applied in the food industry as a thickening and gelation agent as a result of its unique colloidal properties of effective viscosity enhancement and thermal-irreversible gelling. This review first narrates the typical commercial KGM source species, the industrial production, and the purification process of KGM flour. The structural information on native KGM, gelation mechanisms of alkali-induced deacetylated KGM (Da-KGM) hydrogel, progress on degraded KGM derivatives, cryoprotection effect, and colloidal nutrition are highlighted. Finally, the regulatory requirements of konjac flour and KGM among different countries are briefly introduced. The fine structure and physicochemical properties of KGM can be regulated in a great range via the deacetylation or degradation reaction. Here, the relationship between the physicochemical properties, such as viscosity, solubility, gelation, and nutritional effects, of native KGM, Da-KGM, and degraded KGM derivatives was preliminary established, which would provide theoretical guidance for designing KGM-based products with certain nutritional needs.

show abstract

“…Prebiotics can selectively influence and modify GM composition by promoting the growth of certain microorganisms. Several recent studies have shown that prebiotics such as Konjoc oligosaccharides, GOS, FOS can significantly enhance bone mass by reversing dysbiosis ( Ai et al, 2021 ; Zhang et al, 2021 ). Prebiotics also enhance bone mass by decreasing intestinal permeability and thus preventing systemic inflammation ( Zhang et al, 2021 ).…”

Section: Dietary Interventions and Modulation Of Gut Microbiotamentioning

confidence: 99%

“Osteomicrobiology”: The Nexus Between Bone and Bugs

et al. 2022

View full text Add to dashboard Cite

A growing body of scientific evidence supports the notion that gut microbiota plays a key role in the regulation of various physiological and pathological processes related to human health. Recent findings have now established that gut microbiota also contributes to the regulation of bone homeostasis. Studies on animal models have unraveled various underlying mechanisms responsible for gut microbiota-mediated bone regulation. Normal gut microbiota is thus required for the maintenance of bone homeostasis. However, dysbiosis of gut microbiota communities is reported to be associated with several bone-related ailments such as osteoporosis, rheumatoid arthritis, osteoarthritis, and periodontitis. Dietary interventions in the form of probiotics, prebiotics, synbiotics, and postbiotics have been reported in restoring the dysbiotic gut microbiota composition and thus could provide various health benefits to the host including bone health. These dietary interventions prevent bone loss through several mechanisms and thus could act as potential therapies for the treatment of bone pathologies. In the present review, we summarize the current knowledge of how gut microbiota and its derived microbial compounds are associated with bone metabolism and their roles in ameliorating bone health. In addition to this, we also highlight the role of various dietary supplements like probiotics, prebiotics, synbiotics, and postbiotics as promising microbiota targeted interventions with the clinical application for leveraging treatment modalities in various inflammatory bone pathologies.

show abstract

Konjac Oligosaccharides Modulate the Gut Environment and Promote Bone Health in Calcium-Deficient Mice

Cited by 19 publications

References 52 publications

Integrative Analysis of the Gut Microbiota and Metabolome for In Vitro Human Gut Fermentation Modeling

Integrative Analysis of the Gut Microbiota and Metabolome for In Vitro Human Gut Fermentation Modeling

Konjac Glucomannan (KGM), Deacetylated KGM (Da-KGM), and Degraded KGM Derivatives: A Special Focus on Colloidal Nutrition

“Osteomicrobiology”: The Nexus Between Bone and Bugs

Contact Info

Product

Resources

About