Tests for the Elements, their Ions and Compounds

Feigl, F.; Anger, V.

doi:10.1016/b978-0-444-40929-4.50007-5

Cited by 12 publications

(9 citation statements)

References 1,050 publications

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“…Glikin) grown to confluence in complete DMEM medium were treated with DABO (1 mM in complete DMEM for 24 and 48 h), washed and mounted in phosphate-buffered saline, and observed under phase contrast microscopy. Cytochemical attempts to reveal boron in DABO-treated cells using morin-and benzoin-induced fluorescence with borate groups (Udenfriend, 1962;Feigl and Anger, 1972;Frohne, 1974) under 436 and 365 nm excitation, respectively, were also carried out.…”

Section: Methodsmentioning

confidence: 99%

In vivo polymerization of the dopamine-borate melanin precursor: A proof-of-concept regarding boron neutron-capture therapy for melanoma

Stockert¹,

ROMERO²,

Felix-Pozzi³

et al. 2023

Biocell

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The 10 boron neutron-capture therapy (BNCT) is an emerging antitumoral method that shows increasing biomedical interest. BNCT is based on the selective accumulation of the 10 boron isotope within the tumor, which is then irradiated with low-energy thermal neutrons, generating nuclear fission that produces 7 lithium, 4 helium, and γ rays. Simple catechol-borate esters have been rather overlooked as precursors of melanin biosynthesis, and therefore, a proof-of-concept approach for using dopamine-borate (DABO) as a suitable boron-containing candidate for potential BNCT is presented here. DABO can spontaneously oxidize and autopolymerize in vitro, giving a soluble, eumelaninlike brown-black poly-DABO product. Melanotic melanoma cell cultures treated with 1 mM DABO for 24 and 48 h were viable and showed no signs of damage or cell death. The stability and possible trans-esterification of DABO is shortly discussed. Chemical calculations and quantitative structure-activity relationships (QSAR) analysis of DABO and the BNCT agent BPA indicated that they should be cell permeant and accumulate within lysosomes and melanosomes. Molecular modeling allows visualization of both the DABO precursor and the structure of a borate derivative of the proposed catechol-porphycene model for eumelanin, showing interesting features from molecular orbital calculations. The main difference between DABO and other agents, such as BPA, is that it is not a boronic acid nor a boron cluster. This simple catechol-borate ester (protected from oxidation and blackening) could be administrated to living cells and organisms, in which biosynthesis of boron-melanin in melanoma melanocytes can lead to improved BNCT.

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Section: Methodsmentioning

confidence: 99%

In vivo polymerization of the dopamine-borate melanin precursor: A proof-of-concept regarding boron neutron-capture therapy for melanoma

Stockert¹,

ROMERO²,

Felix-Pozzi³

et al. 2023

Biocell

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“…45 Chalcogenides can be detected in aqueous systems by various chemical means, including via the addition of hydrazine, thiourea, hydriodic acid, acidic iron(II) sulfate solution, or aqueous BaCl 2 solution. 46 In this work, the iron(II) sulfate with phosphoric acid test was employed, as it results in the formation of the same elemental chalcogenide precipitates in DES media as it does in aqueous media. The results of these tests can be seen for Ag 2 Se/Ag 2 Te and ZnSe/ ZnTe in Figure 6.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

A Unified Method for the Recovery of Metals from Chalcogenides

Bevan

Galeb

Black

et al. 2021

ACS Sustainable Chem. Eng.

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Metal chalcogenides are ubiquitous starting materials for the extraction of metals from both primary and secondary sources. In this study, it is shown that chalcogenide compounds are electrochemically active and can be solubilized from solid powders by electrochemical oxidation in a deep eutectic solvent. Importantly, the metal ions released into solution were unaffected by the type of chalcogenide present in the initial compound, maintaining the same speciation as would be obtained from dissolution of a chloride salt. Therefore, metals can be recovered by the same process from mixtures of chalcogenides. The chalcogenides form a mixture of oxyanions in the + IV and + VI oxidation states, which are separable via standard processes.

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“…For this purpose, the highly concentrated crude azide mixtures leaving the coil reactor (FlowSyn) were diluted with MeOH and directly introduced into the flow hydrogenator (H‐Cube) (Scheme ). Apparently, TMSN 3 does not interfere with the hydrogenation reaction, and importantly, from a safety standpoint, no HN 3 was detectable in the reaction mixtures after the reduction 16. Therefore, this hydrogenation step additionally serves as an efficient method to destroy excess/unreacted HN 3 formed in the ring‐opening process.…”

Section: Methodsmentioning

confidence: 97%

“…In the above batch‐type experiments, HN 3 could be detected in the headspace above the solvent mixture immediately upon mixing TMSN 3 with MeOH (Figure S1 in the Supporting Information) 16. Given the numerous safety issues in handling HN 3 ,8 we therefore envisaged a continuous‐flow strategy for the ring‐opening of oxazolines, whereby HN 3 is generated in situ in a microreactor environment and subsequently consumed by the reaction with the oxazoline.…”

Section: Methodsmentioning

confidence: 99%