2020
DOI: 10.1186/s12935-020-01456-9
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TET2 suppresses nasopharyngeal carcinoma progression by inhibiting glycolysis metabolism

Abstract: Background Nasopharyngeal carcinoma (NPC) is a common malignant tumor. Ten-eleven translocation (TET) protein 2 (TET2), an evolutionarily conserved dioxygenases, is reported to be involved in various malignant tumor developments. Here, we aim to investigate the effect of TET2 on NPC progress in vitro and in vivo, and its detailed underlying mechanism. Methods Real-time PCR and western blotting were used to determine the expression levels of TET1/2/3 in NPC cell lines. T… Show more

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Cited by 27 publications
(18 citation statements)
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“…PCMTD1 is used as a potential passenger gene in EC [39]. In addition, TET2 is a DNA methylcytosine dioxygenase that is closely related to tumor resistance and tumor metastasis [40][41][42]. Therefore, we speculate that BTG1 is involved in EC neutralization signal transduction, membrane transport, cytoskeleton rearrangement, EC drug resistance, and metastasis, to a large extent.…”
Section: Discussionmentioning
confidence: 99%
“…PCMTD1 is used as a potential passenger gene in EC [39]. In addition, TET2 is a DNA methylcytosine dioxygenase that is closely related to tumor resistance and tumor metastasis [40][41][42]. Therefore, we speculate that BTG1 is involved in EC neutralization signal transduction, membrane transport, cytoskeleton rearrangement, EC drug resistance, and metastasis, to a large extent.…”
Section: Discussionmentioning
confidence: 99%
“…28,29 Also, many studies used DMOG as a TET inhibitor to inhibit TET activity both in vivo and in vitro. [30][31][32] Based on this presented the IOP change in response to rhGDF7 delivery or/and nGDF7 treatment in monkey eyes (n = 4 per group). (D) Immunofluorescence labeling with N-cad, a-SMA, and FN was conducted in monkey TM tissues, and collagen accumulation was determined by Masson trichrome staining (n = 4 per group).…”
Section: Discussionmentioning
confidence: 99%
“…The expression level of SH3BGRL is also considered a diagnostic index of breast cancer [37][38] .PCMTD1 is used as a potential passenger gene in EC [39] . In addition, TET2 is a DNA methylcytosine dioxygenase that is closely related to tumor resistance and tumor metastasis [40][41][42] . Therefore, we speculate that BTG1 is involved in EC neutralization signal transduction, membrane transport, cytoskeleton rearrangement, EC drug resistance, and metastasis, to a large extent.…”
Section: Discussionmentioning
confidence: 99%