Tetanus vaccination is associated with differential DNA-methylation: Reduces the risk of asthma in adolescence

Janjanam, Vimala Devi; Mukherjee, Nandini; Lockett, Gabrielle A.; Rezwan, Faisal I.; Kurukulaaratchy, Ramesh; Mitchell, Frances; Zhang, Hongmei; Arshad, Hasan; Holloway, John W.; Karmaus, Wilfried

doi:10.1016/j.vaccine.2016.10.068

Cited by 16 publications

(10 citation statements)

References 36 publications

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“…Vaccination has been associated with increased circulating IgE levels and therefore postulated to lead to an increased risk of asthma and other allergies [63]. There is, however, little support for this hypothesis in the literature [64]. In a recent EWAS using the Isle of Wright cohort [65], methylation of two CpGs near immune related genes was associated with tetanus vaccination at genome-wide significance and the two of them were also associated with a decreased risk of asthma.…”

Section: Environment and Epigenetics In Asthma And Allergymentioning

confidence: 99%

Recent findings in the genetics and epigenetics of asthma and allergy

Kabesch¹,

Tost

2020

Semin Immunopathol

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In asthma and allergy genetics, a trend towards a few main topics developed over the last 2 years. First, a number of studies have been published recently which focus on overlapping and/or very specific phenotypes: within the allergy spectrum but also reaching beyond, looking for common genetic traits shared between different diseases or disease entities. Secondly, an urgently needed focus has been put on asthma and allergy genetics in populations genetically different from European ancestry. This acknowledges that the majority of new asthma patients today are not white and asthma is a truly worldwide disease. In epigenetics, recent years have seen several large-scale epigenome-wide association studies (EWAS) being published and a further focus was on the interaction between the environment and epigenetic signatures. And finally, the major trends in current asthma and allergy genetics and epigenetics comes from the field of pharmacogenetics, where it is necessary to understand the susceptibility for and mechanisms of current asthma and allergy therapies while at the same time, we need to have scientific answers to the recent availability of novel drugs that hold the promise for a more individualized therapy.

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Section: Environment and Epigenetics In Asthma And Allergymentioning

confidence: 99%

Recent findings in the genetics and epigenetics of asthma and allergy

Kabesch¹,

Tost

2020

Semin Immunopathol

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“…• β-glucan (Candida albicans) [36,59,61] • Lipopolysaccharide (Porphyromonas gingivalis, Escherichia coli, Fusobacterium nucleatum) [37] • BaSET (Bacillus anthracis) [38] • 2-aminoacetophenone (Pseudomonas aeruginosa) [68] • Neonatal sepsis [102,103] • Periodontitis (Porphyromonas gingivalis) [87,88] • Chorioamnionitis [100] • Tetanus [58] some studies examined more than one pathogen or conducted experiments both in humans and human cells or cell lines.…”

Section: Clinical Infections Toxinsmentioning

confidence: 99%

“…The role of epigenetics in the ability of vaccines, including BCG and pertussis, to modulate allergic disease risk is poorly understood [56,57]. In a whole population birth cohort on the Isle of Wight in 1989, tetanus vaccination was associated with differential DNA methylation and a reduced risk of asthma in adolescence [58].…”

Section: Disease Riskmentioning

confidence: 99%

The emerging role of epigenetics in the immune response to vaccination and infection: a systematic review

et al. 2020

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Extensive research has highlighted the role of infection-induced epigenetic events in the development of cancer. More recently, attention has focused on the ability of non-carcinogenic infections, as well as vaccines, to modify the human epigenome and modulate the immune response. This review explores this rapidly evolving area of investigation and outlines the many and varied ways in which vaccination and natural infection can influence the human epigenome from modulation of the innate and adaptive immune response, to biological ageing and modification of disease risk. The implications of these epigenetic changes on immune regulation and their potential application to the diagnosis and treatment of chronic infection and vaccine development are also discussed.

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“…Another study on a whole population birth cohort reported differentiated DNA methylation patterns in certain CpG sites in the Guthrie cards and whole blood of followed-up female participants who had Tetanus vaccination between the ages 10 and 18. At age 18, this observed altered CpG methylation level was associated with lower odds of asthma susceptibility, so it can be proposed as a preventative approach against developing this disease [ 63 ]. In contrast, consuming oral contraceptive pills (OCP) at age 18 was reported to increase the predisposition to asthma by impacting the GATA3 gene through the SNP-CpG methylation interplay, which was assessed using peripheral blood cells and saliva samples (Fig.…”

Section: The Impact Of Subject's Characteristicsmentioning

confidence: 99%

A review of epigenetic changes in asthma: methylation and acetylation

et al. 2021

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Several studies show that childhood and adulthood asthma and its symptoms can be modulated through epigenetic modifications. Epigenetic changes are inheritable modifications that can modify the gene expression without changing the DNA sequence. The most common epigenetic alternations consist of DNA methylation and histone modifications. How these changes lead to asthmatic phenotype or promote the asthma features, in particular by immune pathways regulation, is an understudied topic. Since external effects, like exposure to tobacco smoke, air pollution, and drugs, influence both asthma development and the epigenome, elucidating the role of epigenetic changes in asthma is of great importance. This review presents available evidence on the epigenetic process that drives asthma genes and pathways, with a particular focus on DNA methylation, histone methylation, and acetylation. We gathered and assessed studies conducted in this field over the past two decades. Our study examined asthma in different aspects and also shed light on the limitations and the important factors involved in the outcomes of the studies. To date, most of the studies in this area have been carried out on DNA methylation. Therefore, the need for diagnostic and therapeutic applications through this molecular process calls for more research on the histone modifications in this disease.

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Tetanus vaccination is associated with differential DNA-methylation: Reduces the risk of asthma in adolescence

Cited by 16 publications

References 36 publications

Recent findings in the genetics and epigenetics of asthma and allergy

Recent findings in the genetics and epigenetics of asthma and allergy

The emerging role of epigenetics in the immune response to vaccination and infection: a systematic review

A review of epigenetic changes in asthma: methylation and acetylation

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