Tetracaine from urethral ointment causes false positive amphetamine results by immunoassay

Wijngaard, Robin; Parra‐Robert, Marina; Escalante, Anna; Salgado, Emilio; González-de-la-Presa, Bernardino; To‐Figueras, Jordi; Brunet, Mercè

doi:10.1080/15563650.2020.1834114

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…These results infer that nearly 80% of the reported F/P AMP cases in urine samples obtained from emergency department patients could be attributed to tetracaine. This significant discovery underscores the necessity of considering potential drug interference during the interpretation of immunoassay results and unequivocally affirms tetracaine's interference in the CEDIA Amphetamine/Ecstasy IA [39].…”

Section: Local Anesthetic Agentsmentioning

confidence: 64%

Guilty or not guilty? — False positive results of common medicines in drug tests: review and practical guide

2023

Folia Medica Cracoviensia

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Drug-abuse detection tests are becoming increasingly commonplace in patient care today and provide a rapid and effective method for identifying illicit substances. Occasionally, they may yield a positive result, indicating the presence of a substance, even though the individual has not consumed the suspected drug what sometimes can significantly impact both medical and legal decisions. The study outlines the substances that can lead to false-positive drug test results for amphetamines, cannabinoids, and benzodiazepines. The study's findings have revealed pivotal insights for patients receiving chronic treatment and their primary care physicians. Notably, amphetamine assays appear to be most prone to cross-reactivity with other substances. The beta-blocker group of medications, confirmed by various studies to interfere with amphetamine assays, could pose a substantial challenge in drug screening given its widespread use. Efavirenz also warrants mention, as it frequently triggers positive results for both benzodiazepine and cannabinoid assays among its users. This research helps highlight new areas for further investigation and aims to guide clinicians in their daily practice, especially when interpreting questionable positive drug-abuse test results. This comprehensive review serves as a valuable resource for clinicians to navigate false-positive scenarios effectively and maintain the highest standard of patient care.

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Section: Local Anesthetic Agentsmentioning

confidence: 64%

Guilty or not guilty? — False positive results of common medicines in drug tests: review and practical guide

2023

Folia Medica Cracoviensia

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“…Some new reagents or technologies may cross-react with other substances in the sample, leading to false positive results. 203 This can be particularly problematic in complex samples like blood or urine. In addition, some new reagents may bind non-specifically to LFA components, leading to false positives that can be difficult to detect and correct in the assay design.…”

Section: Challenges In Incorporating New Technologies and Reagents In...mentioning

confidence: 99%

New technologies and reagents in lateral flow assay (LFA) designs for enhancing accuracy and sensitivity

Dey¹,

Iftesum²,

Devireddy³

et al. 2023

Anal. Methods

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Psychiatric and non-psychiatric drugs causing false-positive amphetamines urine test in psychiatric patients: a pharmacovigilance analysis using FAERS

Battini

Cirnigliaro

Giacovelli

et al. 2023

Expert Review of Clinical Pharmacology

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Tetracaine from urethral ointment causes false positive amphetamine results by immunoassay

Cited by 4 publications

References 22 publications

Guilty or not guilty? — False positive results of common medicines in drug tests: review and practical guide

Guilty or not guilty? — False positive results of common medicines in drug tests: review and practical guide

New technologies and reagents in lateral flow assay (LFA) designs for enhancing accuracy and sensitivity

Psychiatric and non-psychiatric drugs causing false-positive amphetamines urine test in psychiatric patients: a pharmacovigilance analysis using FAERS

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