Tetracycline-resistance in lactose-positive enteric coliforms originating from Belgian fattening pigs: Degree of resistance, multiple resistance and risk factors

Dewulf, Jeroen; Catry, Boudewijn; Timmerman, Tom; Opsomer, G.; Kruif, Aart de; Maes, Dominiek

doi:10.1016/j.prevetmed.2006.11.001

Cited by 55 publications

(64 citation statements)

References 30 publications

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“…14 Moreover, Dewulf et al did not find any significant effect by the number of animals per herd or per compartment (univariable analysis). 25 Dunlop et al found higher carbadox resistance rates in larger herds (examined farrow-to-finish farms with 31-90, 91-120, 121-150, or >150 sows). However, resistance to six additionally examined antimicrobials did not show any clear direction of association with herd size.…”

Section: Farm/herd Managementmentioning

confidence: 99%

Risk Factors for Antimicrobial Resistance in Escherichia coli in Pigs Receiving Oral Antimicrobial Treatment: A Systematic Review

Burow

Käsbohrer

2017

Microbial Drug Resistance

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The aim of this literature review was to identify risk factors in addition to antimicrobial treatment for antimicrobial resistance (AMR) occurrence in commensal Escherichia coli in pigs. A variety of studies were searched in 2014 and 2015. Studies identified as potentially relevant were assessed against eligibility criteria such as observation or experiment (no review), presentation of risk factors in addition to (single dosage) antimicrobial use, risk factors for but not resulting from AMR, and the same antimicrobial used and tested. Thirteen articles (nine on observational, four on experimental studies) were finally selected as relevant. It was reported that space allowance, production size/stage, cleanliness, entry of animals and humans into herds, dosage/frequency/route of administration, time span between treatment and sampling date, herd size, distance to another farm, coldness, and season had an impact on AMR occurrence. Associations were shown by one to four studies per factor and differed in magnitude, direction, and level of significance. The risk of bias was unclear in nearly half of the information of observational studies and in most of the information from experimental studies. Further research on the effects of specific management practices is needed to develop well-founded management advice.

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Section: Farm/herd Managementmentioning

confidence: 99%

Risk Factors for Antimicrobial Resistance in Escherichia coli in Pigs Receiving Oral Antimicrobial Treatment: A Systematic Review

Burow

Käsbohrer

2017

Microbial Drug Resistance

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“…Many studies of the presence of antimicrobial resistance in several animal-producing environments such as sheep, cattle, swine, or broiler farms have been conducted (13)(14)(15)(16)(17)(18)(19)(20)(21). However, only a few publications are available about studies of whether vegetables or the environment where they are produced can act as a carrier or reservoir of antimicrobial resistance (22,23).…”

mentioning

confidence: 99%

Moderate Prevalence of Antimicrobial Resistance in Escherichia coli Isolates from Lettuce, Irrigation Water, and Soil

Holvoet

Sampers

Callens

et al. 2013

Appl Environ Microbiol

104

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cFresh produce is known to carry nonpathogenic epiphytic microorganisms. During agricultural production and harvesting, leafy greens can become contaminated with antibiotic-resistant pathogens or commensals from animal and human sources. As lettuce does not undergo any inactivation or preservation treatment during processing, consumers may be exposed directly to all of the (resistant) bacteria present. In this study, we investigated whether lettuce or its production environment (irrigation water, soil) is able to act as a vector or reservoir of antimicrobial-resistant Escherichia coli. Over a 1-year period, eight lettuce farms were visited multiple times and 738 samples, including lettuce seedlings (leaves and soil), soil, irrigation water, and lettuce leaves were collected. From these samples, 473 isolates of Escherichia coli were obtained and tested for resistance to 14 antimicrobials. Fiftyfour isolates (11.4%) were resistant to one or more antimicrobials. The highest resistance rate was observed for ampicillin (7%), followed by cephalothin, amoxicillin-clavulanic acid, tetracycline, trimethoprim, and streptomycin, with resistance rates between 4.4 and 3.6%. No resistance to amikacin, ciprofloxacin, gentamicin, or kanamycin was observed. One isolate was resistant to cefotaxime. Among the multiresistant isolates (n ‫؍‬ 37), ampicillin and cephalothin showed the highest resistance rates, at 76 and 52%, respectively. E. coli isolates from lettuce showed higher resistance rates than E. coli isolates obtained from soil or irrigation water samples. When the presence of resistance in E. coli isolates from lettuce production sites and their resistance patterns were compared with the profiles of animal-derived E. coli strains, they were found to be the most comparable with what is found in the cattle reservoir. This may suggest that cattle are a potential reservoir of antimicrobial-resistant E. coli strains in plant primary production.

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“…Tetracycline resistance is conferred through tet and otr genes (Roberts, 2011), and subtherapeutic use of tetracycline has been shown to induce tetracycline-resistant genotypes as well as phenotypes (Funk et al, 2006;Dewulf et al, 2007;Agga et al, 2014). In addition, tetracycline resistance is associated with ampicillin drug resistance among Gram-negative bacteria (Funk et al, 2006;Dewulf et al, 2007). In the present study, the ampicillin resistance remained high over time but tetracycline resistance decreased throughout the finishing period among E. coli isolates whereas tetracycline resistance concomitantly increased among Enterococcus isolates.…”

Section: Continuedmentioning

confidence: 46%

“…Similar observations have led to the postulation that the gastrointestinal microbiota of older animals is less vulnerable to a population with multiple antibiotic-resistant bacteria compared with younger animals (Langlois et al, 1986;Dewulf et al, 2007;Berge et al, 2010). This phenomenon could also be an artifact of greater antimicrobial use among younger livestock inducing microbial drug resistance early in life and then decreasing selection pressure over time causing these resistant microbes to have poorer relative competitiveness and survival (Dewulf et al, 2007).…”

Section: Continuedmentioning

confidence: 91%

“…This low bacterial susceptibility to tetracycline and ampicillin may be reflective of these drugs' use in upstream production within the sow herd. Tetracycline resistance is conferred through tet and otr genes (Roberts, 2011), and subtherapeutic use of tetracycline has been shown to induce tetracycline-resistant genotypes as well as phenotypes (Funk et al, 2006;Dewulf et al, 2007;Agga et al, 2014). In addition, tetracycline resistance is associated with ampicillin drug resistance among Gram-negative bacteria (Funk et al, 2006;Dewulf et al, 2007).…”

Section: Continuedmentioning

confidence: 99%

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Effects of dietary copper, zinc, and ractopamine hydrochloride on finishing pig growth performance, carcass characteristics, and antimicrobial susceptibility of enteric bacteria12

Feldpausch¹,

Amachawadi

Tokach³

et al. 2016

Journal of Animal Science

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Tetracycline-resistance in lactose-positive enteric coliforms originating from Belgian fattening pigs: Degree of resistance, multiple resistance and risk factors

Cited by 55 publications

References 30 publications

Risk Factors for Antimicrobial Resistance in Escherichia coli in Pigs Receiving Oral Antimicrobial Treatment: A Systematic Review

Risk Factors for Antimicrobial Resistance in Escherichia coli in Pigs Receiving Oral Antimicrobial Treatment: A Systematic Review

Moderate Prevalence of Antimicrobial Resistance in Escherichia coli Isolates from Lettuce, Irrigation Water, and Soil

Effects of dietary copper, zinc, and ractopamine hydrochloride on finishing pig growth performance, carcass characteristics, and antimicrobial susceptibility of enteric bacteria12

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