Tetracycline toxicity in haemoglobinuria.

Azotaemia Aggravated by Tetracycline

“…Hyperbilirubinaemia, myoglobinaemia, haemoglobinaemia, and dehydration render the kidney-vulnerable to the development of acute tubular necrosis in appropriate circumstances, such as postoperative shock. In animals a combination of haemoglobinaemia and tetracycline may produce renal tubular necrosis, whereas neither alone has this effect (Tapp and Lowe, 1966). In man tetracycline may perhaps have a similar action on an already vulnerable kidney.…”