Tetracyclines

Laskin, Allen I.

doi:10.1007/978-3-662-38439-8_23

Cited by 12 publications

(2 citation statements)

References 101 publications

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“…It may be significant that at 10-4 m chlortetracycline, a level sufficient to inhibit polyphenylalanine synthesis maximally (Suarez and Nathans, 1965), A-acetyl-L-phenylalanyl-tRNA binding is inhibited only 20%. Since at levels of 10~4 m chlortetracycline and greater the g chelation of Mg2+ by the antibiotic (see Laskin, 1967) m may significantly reduce the Mg2+ available for binding of N-acetyl-L-phenylalanyl-tRNA to ribosomes, caution must be exercised in interpreting effects at such chlortetracycline concentrations.…”

Section: Methodsmentioning

confidence: 99%

Inhibition by pactamycin of the initiation of protein synthesis. Binding of N-acetylphenylalanyl transfer ribonucleic acid and polyuridylic acid to ribosomes

Cohen¹,

Herner²,

Goldberg³

1969

Biochemistry

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Section: Methodsmentioning

confidence: 99%

Inhibition by pactamycin of the initiation of protein synthesis. Binding of N-acetylphenylalanyl transfer ribonucleic acid and polyuridylic acid to ribosomes

Cohen¹,

Herner²,

Goldberg³

1969

Biochemistry

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“…In contrast to mammalian cells, cells of most bacterial species actively concentrate them . Antibacterial activity of typical tetracyclines is associated with the reversible inhibition of the protein synthesis (Laskin, 1967;Kersten and Frey, 1972). Binding of the drug to the ribosome prevents the a�achment of the aminoacyl-tRNA to the "A site" of the ribosome.…”

Section: Mode Of Actionmentioning

confidence: 99%

Tetracyclines in veterinary medicine and bacterial resistance to them

Michalova¹,

PNovotna²,

Schlegelová³

2004

Vet. Med.

121

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Since their discovery in 1945, tetracyclines have been used extensively in the therapy and prophylaxis of infectious diseases and as growth promoters. These wide applications have led to the equally fast spread of tetracycline resistant strains of gram-positive and gram-negative bacterial genera, including strains belonging to pathogenic as well as nonpathogenic species. Nonpathogenic bacteria could act as a reservoir of resistance determinants, which can be disseminated by horizontal transfer into pathogens. More than thirty different tetracycline resistance genes have been characterized. They encode two major mechanisms of resistance: 1 -active efflux of the antibiotic, and 2 -protection of ribosomes. Further mechanisms of tetracycline resistance include enzymatic inactivation of antibiotic, permeability barriers, mutations or multidrug transporter systems. Effective horizontal spread is favoured by the location of tetracycline resistance genes on mobile genetic elements such as plasmids and transposons. Their exchange, enhanced by the use of tetracyclines, is observed between bacteria of the same or different species and genera as well. Thus, questions of reevaluating and global reducing of tetracyclines in human and animal healthcare and food production are extensively discussed.

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Tetracycline: Chemie, Biochemie und Struktur‐Wirkungs‐Beziehungen

Dürckheimer

1975

Angewandte Chemie

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Die Antibiotika der Tetracyclin-Reihe spielen nach wie vor eine wichtige Rolle in der Humanund Veterinarmedizin sowie in der Tiererniihrung. Zu den klassischen, fermentativ gewonnenen Tetracyclinen sind partialsynthetische Produkte gekommen, die vor allem durch giinstigere pharmakokinetische Eigenschaften und bessere Vertraglichkeit Vorteile bieten. Nach einem Ruckblick auf altere Arbeiten werden Partial-und Totalsynthesen von Tetracyclinen und die Einflusse elektronischer, sterischer und lipophiler Faktoren sowie der Komplexbildung auf die biologische Wirksamkeit beschrieben. Auch auf die Hemmung biochemischer Systeme, die fur die Deutung der Wirkungsweise von Interesse sind, und auf Probleme der Resistenzentwicklung wird eingegangen.

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Tetracyclines

Cited by 12 publications

References 101 publications

Inhibition by pactamycin of the initiation of protein synthesis. Binding of N-acetylphenylalanyl transfer ribonucleic acid and polyuridylic acid to ribosomes

Inhibition by pactamycin of the initiation of protein synthesis. Binding of N-acetylphenylalanyl transfer ribonucleic acid and polyuridylic acid to ribosomes

Tetracyclines in veterinary medicine and bacterial resistance to them

Tetracycline: Chemie, Biochemie und Struktur‐Wirkungs‐Beziehungen

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