Tetrandrine stimulates the apoptosis of hepatic stellate cells and ameliorates development of fibrosis in a thioacetamide rat model

Yin, Mingfu; Lian, Li-Hua; Piao, Dong-Ming; Nan, Ji‐Xing

doi:10.3748/wjg.v13.i8.1214

Cited by 27 publications

(18 citation statements)

References 27 publications

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“…CHM has been used as a complementary and alternative therapy in disease prevention for centuries and is potent for preventing liver fibrosis. Currently, a number of anti-liver fibrosis compounds have been discovered from CHM in various forms such as oxymatrine [21], matrine [22], tetrandrine [23], silybin [24], puerarin [25], quercetin [26], salvianolic acid B [27], curcumin [28] and so on. Paeoniflorin, serving as an effective anti-liver fibrosis compound, displays its function via a variety of signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway

Yan

Wang

et al. 2014

Fitoterapia

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Section: Discussionmentioning

confidence: 99%

Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway

Yan

Wang

et al. 2014

Fitoterapia

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“…While two-dimensional in vitro systems have been invaluable in elucidating the effects of mechanical forces on cells and the mechanisms of mechanotransduction, cells function within a three-dimensional environment whose mechanical properties can change during development [27] or various pathological conditions including fibrosis [28, 29], cancer [30–34], and atherosclerosis [35]. Due to accumulation of ECM components and cross-linking of these components, alterations in tissue stiffness are a common feature of fibrosis.…”

Section: Effects Of Tissue Stiffness On Fibrosismentioning

confidence: 99%

Regulation of Tissue Fibrosis by the Biomechanical Environment

Carver

Goldsmith

2013

BioMed Research International

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The biomechanical environment plays a fundamental role in embryonic development, tissue maintenance, and pathogenesis. Mechanical forces play particularly important roles in the regulation of connective tissues including not only bone and cartilage but also the interstitial tissues of most organs. In vivo studies have correlated changes in mechanical load to modulation of the extracellular matrix and have indicated that increased mechanical force contributes to the enhanced expression and deposition of extracellular matrix components or fibrosis. Pathological fibrosis contributes to dysfunction of many organ systems. A variety of in vitro models have been utilized to evaluate the effects of mechanical force on extracellular matrix-producing cells. In general, application of mechanical stretch, fluid flow, and compression results in increased expression of extracellular matrix components. More recent studies have indicated that tissue rigidity also provides profibrotic signals to cells. The mechanisms whereby cells detect mechanical signals and transduce them into biochemical responses have received considerable attention. Cell surface receptors for extracellular matrix components and intracellular signaling pathways are instrumental in the mechanotransduction process. Understanding how mechanical signals are transmitted from the microenvironment will identify novel therapeutic targets for fibrosis and other pathological conditions.

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“…[4][5][6] Tetrandrine, a bisbenzylisoquinoline alkaloid, was isolated from the root of Stephania tetrandra and used in traditional Chinese medicine as an antirheumatic, anti-inflammatory, antihypertensive agent. [7][8][9] Tetrandrine has been demonstrated in studies to have anti-inflammatory, immunosuppressive, and cytoprotective effects. 10,11 It suppresses T and B cells and inhibits the production of inflammatory factors and cytokines such as histamine, prostaglandins, and tumor necrosis factor-a (TNFa).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Radiosensitivity and the Potential Mechanism on Human Esophageal Carcinoma Cells by Tetrandrine

Liu

Sun

et al. 2011

Cancer Biotherapy and Radiopharmaceuticals

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The purposes of this study were to test the effect of tetrandrine, alone or combined with radiation, on human esophageal cancer cell line TE1 (TE1 cells) and investigate the potential antitumor mechanism. Human esophageal cancer cell line TE1 was tested by methyl thiazolyl tetrazolium assay for cell proliferation, colony-forming assay for cell radiosensitivity, flow cytometry assay for cell cycle distribution, and western blot assay for cell cycle protein expression. When treated alone, tetrandrine had a time- and concentration-dependent cytotoxic effect on TE1 cells. The dose-enhancement ratio for combined tetrandrine and radiation was markedly increased when compared with tetrandrine alone. Further, expression of cyclin B1 protein increased after addition of tetrandrine when compared with radiation only. Radiation-induced G2 arrest was abrogated with treatment of tetrandrine. In conclusion, tetrandrine can enhance the radiosensitivity of TE1 cells and this may involve relief of radiation-induced G2/M arrest in TE1 cells.

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Tetrandrine stimulates the apoptosis of hepatic stellate cells and ameliorates development of fibrosis in a thioacetamide rat model

Cited by 27 publications

References 27 publications

Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway

Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway

Regulation of Tissue Fibrosis by the Biomechanical Environment

Enhancement of Radiosensitivity and the Potential Mechanism on Human Esophageal Carcinoma Cells by Tetrandrine

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