AIM:To investigate the therapeutic effect of tetrandrine on liver fibrosis induced by thioacetamide in rats in vivo and in vitro . METHODS:In vitro study: we investigated the effect of tetrandrine on the apoptosis of rat hepatic stellate cells transformed by simian virus 40 (T-HSC/Cl-6), which retains the features of activated cells. In vivo study: hepatic fibrosis was induced in rats by thioacetamide. Tetrandrine was given orally to rats at doses of 5, 10 or 20 mg/kg for 4 wk compared with intraperitoneal injection of interferon-г.

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PurposeThe purpose of this paper is to improve the bearing capacity and mechanical properties of the oil pocket.Design/methodology/approachIn this paper, a straight-through labyrinth seal is installed in an oil sealing belt. The main structure of hydrostatic support system (HSS) is introduced, and the factors affecting the leakage loss are analyzed. The governing equations involving the momentum equation and the continuity equation for the land section and groove section are established separately based on the three-control-volume theory. To explain the flow capability of the straight-through labyrinth seal, the labyrinth seal with different clearance widths, groove numbers, groove depths and pressure difference is calculated. The results of the simulation are compared and analyzed.FindingsThe groove dimensions and groove numbers have important impact on the leakage and flow pattern of the seal.Research limitations/implicationsThe fluid flow was simulated by commercial tools executed in the ANSYS Fluent, the computational fluid dynamics (CFD) solver and a steady state scheme with the realizable k-ε turbulence model was applied. The cavity structure of the straight-through labyrinth seal, forming turbulence eddy flows in the groove, which is a valid approach to convert turbulence kinetic energy into thermal energy, reduce leakage mass flow.Practical implicationsThis research can provide the theoretical basis and technical support which is conducive to the practical application of the straight-through labyrinth seal in HSS.Social implicationsA new design structure is proposed to improve the bearing capacity and economic benefit of HSSs.Originality/valueA straight-through labyrinth seal is applied to the oil sealing belt and the three-control-volume governing equation is established.

At present, most of the factories carry materials by hand about ceramic. This paper designed the structure of the product with the automatic pick-and-placing manipulator as the research object. Furthermore, it applied 3D model and motion simulation to the product through SolidWorks. Then it gave a design scheme of the manipulator. Finally it obtained the feasibility of the design scheme. At the same time, this paper adopted the control strategy with force ring and position ring and fuzzy control adoptive PID algorithm to ensure the precision requirement. It also made a dynamic model of the manipulator structure for the movement of the manipulator. The control strategy can achieve good control effects through the analysis by MATLAB simulation.