Tex27, a Gene Containing a Zinc-Finger Domain, Is Up-Regulated during the Haploid Stages of Spermatogenesis

Luis, Oscar; López-Fernández, Luis Andrés; Mazo, Jesús del

doi:10.1006/excr.1999.4482

Cited by 24 publications

(21 citation statements)

References 42 publications

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“…Ovo1 2/2 mice have a reduced ability to reproduce. They show a phenotype similar to Bardet-Biedl syndrome, a human disorder that maps to the same locus as human ovo1 (Dai et al, 1998 (de Luis et al, 1999;Passananti et al, 1995). Early growth response 4 [ID: T4-824] belongs to the EGR family of zinc-finger transcription factors involved in cell growth and differentiation.…”

Section: Zinc Fingermentioning

confidence: 89%

Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 4: Intercellular bridges, mitochondria, nuclear envelope, apoptosis, ubiquitination, membrane/voltage‐gated channels, methylation/acetylation, and transcription factors

Hermo

Pelletier

Cyr

et al. 2009

Microscopy Res & Technique

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As germ cells divide and differentiate from spermatogonia to spermatozoa, they share a number of structural and functional features that are common to all generations of germ cells and these features are discussed herein. Germ cells are linked to one another by large intercellular bridges which serve to move molecules and even large organelles from the cytoplasm of one cell to another. Mitochondria take on different shapes and features and topographical arrangements to accommodate their specific needs during spermatogenesis. The nuclear envelope and pore complex also undergo extensive modifications concomitant with the development of germ cell generations. Apoptosis is an event that is normally triggered by germ cells and involves many proteins. It occurs to limit the germ cell pool and acts as a quality control mechanism. The ubiquitin pathway comprises enzymes that ubiquitinate as well as deubiquitinate target proteins and this pathway is present and functional in germ cells. Germ cells express many proteins involved in water balance and pH control as well as voltage-gated ion channel movement. In the nucleus, proteins undergo epigenetic modifications which include methylation, acetylation, and phosphorylation, with each of these modifications signaling changes in chromatin structure. Germ cells contain specialized transcription complexes that coordinate the differentiation program of spermatogenesis, and there are many male germ cell-specific differences in the components of this machinery. All of the above features of germ cells will be discussed along with the specific proteins/genes and abnormalities to fertility related to each topic.

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Section: Zinc Fingermentioning

confidence: 89%

Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 4: Intercellular bridges, mitochondria, nuclear envelope, apoptosis, ubiquitination, membrane/voltage‐gated channels, methylation/acetylation, and transcription factors

Hermo

Pelletier

Cyr

et al. 2009

Microscopy Res & Technique

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“…Seven of the 14 genes showing movement onto polysomes (Tex27, Spata6, Odf2, Ptdss2, Ddc8, Dbil5, and Hdhd1a) are highly enriched in testis. Genes, such as Dbil5, are under translational control (36) similar to Pgk2 (25), whereas others, such as Tex27 (26) and Spata6 (27), show similar increases in RNA levels in postmeiotic cells. Interestingly, all of the 35 genes are located on autosomes, possibly because of the transcriptional silencing of the sex chromosomes during the pachytene stage of meiotic prophase (37,38).…”

Section: Discussionmentioning

confidence: 99%

“…By using Pgk2 as a marker mRNA to detect populations of mRNAs showing similar meiotic expression and translational delays, Ͼ70% of Pgk2 mRNA fractionates as RNPs in the testes of 17-day-old and 22-day-old mice and redistributes onto polysomes in adult mice (Table 10). Fourteen additional mRNAs show similar RNP and polysome distributions (Table 1) (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36), all of which meet the strict criterion of at least 70% in RNPs in prepuberal testes and show a shift of 20% or more to polysomes in adults. Four genes can be added to this group when we lower the percentage of mRNA in the RNPs of 22-day-old mice from 70% to 62% (Table 1).…”

Section: Many Mrnas That Are Transcribed During Meiosis Move Betweenmentioning

confidence: 95%

Expression profiling reveals meiotic male germ cell mRNAs that are translationally up- and down-regulated

Iguchi

Tobias

Hecht

2006

Proc. Natl. Acad. Sci. U.S.A.

138

145

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T he testis contains a diverse population of somatic and germ cell types. As spermatogenesis proceeds, diploid spermatogonia differentiate into meiotic spermatocytes, which divide twice without additional DNA replication, producing haploid round spermatids (1, 2). These spermatids transform into highly polarized and uniquely shaped spermatozoa. As the germ cells differentiate, the changing amounts and populations of mRNAs in the germ cells and somatic cells have been well documented by microarray analyses (3-7) and by the cloning and sequencing of cDNA libraries prepared from highly purified populations of individual cell types (8,9).Although these microarray and cloning studies provide valuable insight into the temporal appearance͞disappearance of individual mRNAs, they do not address the question of when the proteins encoded by the mRNAs are synthesized. In the germ cells of the testis, a temporal disconnect between mRNA transcription and protein synthesis is especially common, in part because RNA synthesis terminates during midspermiogenesis long before the spermatid completes its differentiation into the spermatozoon (1). Thus, posttranscriptional mechanisms play major roles in the temporal regulation of protein synthesis in developing male gametes.

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“…ZFAND3 is known to express preferentially in postmeiotic cells in the mouse testis during spermatogenesis, and the presence of multiple transcripts has been reported (de Luis et al, 1999). These results suggest that ZFAND3 is involved in spermatogenesis, but its physiological function remains unclear because only a few studies on ZFAND3 have been conducted.…”

Section: Introductionmentioning

confidence: 76%

Molecular characterization of two isoforms of ZFAND3 cDNA from the Japanese quail and the leopard gecko, and different expression patterns between testis and ovary

Otake

Endo

Park

2011

Gene

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Tex27, a Gene Containing a Zinc-Finger Domain, Is Up-Regulated during the Haploid Stages of Spermatogenesis

Cited by 24 publications

References 42 publications

Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 4: Intercellular bridges, mitochondria, nuclear envelope, apoptosis, ubiquitination, membrane/voltage‐gated channels, methylation/acetylation, and transcription factors

Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 4: Intercellular bridges, mitochondria, nuclear envelope, apoptosis, ubiquitination, membrane/voltage‐gated channels, methylation/acetylation, and transcription factors

Expression profiling reveals meiotic male germ cell mRNAs that are translationally up- and down-regulated

Molecular characterization of two isoforms of ZFAND3 cDNA from the Japanese quail and the leopard gecko, and different expression patterns between testis and ovary

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