Textbook of Medical Laboratory Technology

Sood, Ramnik

doi:10.5005/jp/books/10919

Cited by 36 publications

(34 citation statements)

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“…In the present study, creatinine and uric acid determinations were critical as markers of kidney function (Newman and Price, 1999). Creatinine is excreted out of the body entirely by the kidneys while uric acid is excreted to a large degree by the kidneys and to a smaller degree in the intestinal tract by microbial degradation (Sood, 2006). Elevated creatinine and uric acid levels in the serum of untreated diabetic rats signify impaired kidney function or disease (Sood, 2006).…”

Section: Discussionmentioning

confidence: 99%

Assessment of acute toxicity profile of Lasianthera africana leaf extract in normal rats and its ameliorative effect in alloxan-induced diabetic rats

Inyang¹,

Nwafor²,

Asamudo³

2015

Afr. J. Biotechnol.

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The present study evaluated the acute toxicity effect of Lasianthera africana leaf extract on normal rats and effect of the extract on the hepatic and renal function indices in alloxan-induced diabetic rats. In the acute toxicity test, male Wister rats received orally four different single dose of the extract and were kept under observation for 14 days. The result indicates that LD 50 of the extract is higher than 5,000 mg/kg body weight. For the second experiment, doses (50, 100 and 200 mg/kg body weight) of the leaf extract were administered orally to alloxan-induced diabetic rats for 28 days and the effect of the treatment on blood glucose, hepatic enzymes, serum proteins and renal function indices was evaluated. The result indicates progressive and significant (p>0.05) reduction in fasting blood glucose. The extract also exhibited significant (p<0.05) reduction in serum aspartate aminotransferase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP), and significant (p<0.05) increase in serum total proteins and globulin and marginal (p>0.05) reduction in serum creatinine and uric acid relative to the diabetic control group. The results suggest that the leaf extract is safe and may be beneficial in the management of diabetic mellitus.

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Section: Discussionmentioning

confidence: 99%

Assessment of acute toxicity profile of Lasianthera africana leaf extract in normal rats and its ameliorative effect in alloxan-induced diabetic rats

Inyang¹,

Nwafor²,

Asamudo³

2015

Afr. J. Biotechnol.

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“…The total numbers of sperms were counted in the 5 major squares on each side of the haemocytometer and determined the average for calculating sperm count. [9] The haemocytometer is 0.1mm deep and the 25 large squares represent an area of 1 square millimeter with a volume of 0.1 µl. When 5 squares are counted, the sperms which are settled out of 0.02 µl only are counted.…”

Section: Sperm Countmentioning

confidence: 99%

Untitled

2017

Hygeia.J.D.Med.

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“…The blood was allowed to clot at room temperature which helps the plasma separate from cells and after two hours serum was separated from blood by centrifuging at 3000 rpm for 10 minutes. The extracted serum was immediately transferred to a plastic vial and stored at -20° C in deep freezer, 13 at Blood Bank Unite of Nanakaly Hospital for Blood Diseases. Sera were testes for TNF-α by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer instruction kit (Koma Biotech INC Human TNF-α /ELISA Kit: Cat# K0331131 U.S.A.) at Virology Unite of the Nanakaly Hospital for Blood Diseases.…”

Section: Stent Preparationmentioning

confidence: 99%

Effect of non surgical periodontal treatment on TNF-α levels in serum of patients with chronic periodontitis

Abdulhameed

Nanakaly

2016

ZJMS

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Background and objective: Chronic periodontitis is a multifactorial inflammatory disease characterized by destruction of tooth supporting tissues. Tumor necrosis factor-α, a key inflammatory cytokine, plays an important role in periodontal destruction. This study aimed to analyze the effect of non-surgical periodontal treatment on tumor necrosis factor-α levels in serum of patient with chronic periodontitis (with and without using chlorhexidine 0.2% mouthwash). Methods: A total of 44 patients with moderate to severe localized chronic periodontitis were divided into: Group I (n=22) without using of chlorhexidine mouthwash and Group II (n=22) with 0.2% chlorhexidine mouthwash. Serum samples collected from each subjects at baseline and four weeks after scaling and root planning treatment were quantified for tumor necrosis factor-α levels using ELISA technique. Results:The mean concentration of TNF-α were significantly reduced one month after treatment in sera of patients with chronic periodontitis for group I when compared to its mean concentration before treatment (P <0.05), while in group II a highly significant reduction after one month treatment (P <0.001) was observed. Conclusion:The effect of non-surgical periodontal therapy with chlorohexidine mouth wash showed more reduction in the levels of serum tumor necrosis factor-α.

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Textbook of Medical Laboratory Technology

Cited by 36 publications

References 0 publications

Assessment of acute toxicity profile of Lasianthera africana leaf extract in normal rats and its ameliorative effect in alloxan-induced diabetic rats

Assessment of acute toxicity profile of Lasianthera africana leaf extract in normal rats and its ameliorative effect in alloxan-induced diabetic rats

Untitled

Effect of non surgical periodontal treatment on TNF-α levels in serum of patients with chronic periodontitis

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