Texture direction of combined microgrooves and submicroscale topographies of titanium substrata influence adhesion, proliferation, and differentiation in human primary cells

Im, Byung Jin; Lee, Suk Won; Oh, Namsik; Lee, Myung Hyun; Kang, Jae-Mo; Liu, Richard; Lee, Sang Cheon; Ahn, Sung Woo; Park, Jae Sang

doi:10.1016/j.archoralbio.2011.11.013

Cited by 27 publications

(20 citation statements)

References 17 publications

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“…Our results are supported by several lines of evidence: (1) controlled grooves significantly increase the mechanical interlock between the implant and joining biomaterial [5]. In addition, cells are especially responsive to groove architecture (particularly shape and direction) and on such surfaces cells aligned and migrated along the groove direction [25,26]; (2) Microscale surface features on implants, such as microroughness [27] and microporosity [28], can act as potent modulators of cellular function through the onset of focal adhesion formation.…”

Section: Discussionsupporting

confidence: 80%

“…Micron to nanometer size grooves can control the cell settlement on implant surfaces or be used to direct tissue generation at the implant/bone interface [4]. A variety of implant surface modifications, including surface cutting, etching, and ion deposition techniques, have been studied and facilitate the formation of an extracellular matrix on the implant surface [4,5,6,7]. Micron to nanosize texturing on the implant is one of the simplest, most scalable, inexpensive, and supplementary surface treatment tools employed to direct the bone response at the interface between an implant and the bone tissue [8,9,10,11,12].…”

Section: Introductionmentioning

confidence: 99%

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Microgroove and Collagen-poly(ε-caprolactone) Nanofiber Mesh Coating Improves the Mechanical Stability and Osseointegration of Titanium Implants

et al. 2017

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The effect of depositing a collagen (CG)-poly-ε-caprolactone (PCL) nanofiber mesh (NFM) at the microgrooves of titanium (Ti) on the mechanical stability and osseointegration of the implant with bone was investigated using a rabbit model. Three groups of Ti samples were produced: control Ti samples where there were no microgrooves or CG-PCL NFM, groove Ti samples where microgrooves were machined on the circumference of Ti, and groove-NFM Ti samples where CG-PCL NFM was deposited on the machined microgrooves. Each group of Ti samples was implanted in the rabbit femurs for eight weeks. The mechanical stability of the Ti/bone samples were quantified by shear strength from a pullout tension test. Implant osseointegration was evaluated by a histomorphometric analysis of the percentage of bone and connective tissue contact with the implant surface. The bone density around the Ti was measured by micro–computed tomography (μCT) analysis. This study found that the shear strength of groove-NFM Ti/bone samples was significantly higher compared to control and groove Ti/bone samples (p < 0.05) and NFM coating influenced the bone density around Ti samples. In vivo histomorphometric analyses show that bone growth into the Ti surface increased by filling the microgrooves with CG-PCL NFM. The study concludes that a microgroove assisted CG-PCL NFM coating may benefit orthopedic implants.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Microgroove and Collagen-poly(ε-caprolactone) Nanofiber Mesh Coating Improves the Mechanical Stability and Osseointegration of Titanium Implants

et al. 2017

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“…It has been shown that texturing of biomaterials increases cell adhesion in comparison to flat, smooth surfaces. Topography of a material can be characterized by different roughness parameters (Ra, Sa, Sm -measured in nanometres) determined by AFM, confocal microscopy, optical profilometry, SEM or tactile profilometry [47]. Knowing that the in vivo microenvironment is not flat, it is important to understand the function of cells grown on topographies that mimic natural conditions.…”

Section: Engineering Biosurface Topographical Cues At the Micro-and Nmentioning

confidence: 99%

Bio-Interfaces Engineering Using Laser-Based Methods for Controlled Regulation of Mesenchymal Stem Cell Response In Vitro

Dinca¹,

Sima²,

Rusen³

et al. 2016

Recent Advances in Biopolymers

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The controlled interfacial properties of materials and modulated behaviours of cells and biomolecules on their surface are the requirements in the development of a new generation of high-performance biomaterials for regenerative medicine applications. Roughness, chemistry and mechanics of biomaterials are all sensed by cells. Organization of the environment at the nano-and the microscale, as well as chemical signals, triggers specific responses with further impact on cell fate. Particularly, human mesenchymal stem cells (hMSCs) hold a great promise in both basic developmental biology studies and regenerative medicine, as progenitors of bone cells. Their fate can be affected by various key regulatory factors (e.g. soluble growth factors, intrinsic, extrinsic environmental factors) that can be delivered by a fabricated scaffold. For example, when cultured on engineered environments that reproduce the physical features of the bone, hMSCs express tissue-specific transcription factors and consequently undergo an osteogenic fate. Therefore, producing smart bio-interfaces with targeted functionalities represents the key point in effective use of hierarchically topographical and chemical bioplatforms. In this chapter, we review laser-based approaches (e.g. Matrix-Assisted Pulsed Laser Evaporation (MAPLE), Laser-Induced Forward Transfer (LIFT), laser texturing and laser direct writing) used for the design of bio-interfaces aimed at controlling stem cell behaviour in vitro.

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“…Although considerable advances have already been made to improve the biological performance of cement, the ideal long-term mechanical stability of a cemented implant has still not been achieved. An ideal cementing material for cemented surgeries should have surface energy and mechanical interlock to ensure a long-lasting fixation between the implant-cement and the cement-bone interfaces [ 1 , 2 , 3 , 4 ]. The critical task for creating a long lasting tissue-implant interface resides in achieving the functional integration to mimic the native tissue-tissue failure response [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Use of Polycaprolactone Electrospun Nanofibers as a Coating for Poly(methyl methacrylate) Bone Cement

et al. 2017

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Poly(methyl methacrylate) (PMMA) bone cement has limited biocompatibility. Polycaprolactone (PCL) electrospun nanofiber (ENF) has many applications in the biomedical field due to its excellent biocompatibility and degradability. The effect of coating PCL ENF on the surface topography, biocompatibility, and mechanical strength of PMMA bone cement is not currently known. This study is based on the hypothesis that the PCL ENF coating on PMMA will increase PMMA roughness leading to increased biocompatibility without influencing its mechanical properties. This study prepared PMMA samples without and with the PCL ENF coating, which were named the control and ENF coated samples. This study determined the effects on the surface topography and cytocompatibility (osteoblast cell adhesion, proliferation, mineralization, and protein adsorption) properties of each group of PMMA samples. This study also determined the bending properties (strength, modulus, and maximum deflection at fracture) of each group of PMMA samples from an American Society of Testing Metal (ASTM) standard three-point bend test. This study found that the ENF coating on PMMA significantly improved the surface roughness and cytocompatibility properties of PMMA (p < 0.05). This study also found that the bending properties of ENF-coated PMMA samples were not significantly different when compared to those values of the control PMMA samples (p > 0.05). Therefore, the PCL ENF coating technique should be further investigated for its potential in clinical applications.

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Texture direction of combined microgrooves and submicroscale topographies of titanium substrata influence adhesion, proliferation, and differentiation in human primary cells

Cited by 27 publications

References 17 publications

Microgroove and Collagen-poly(ε-caprolactone) Nanofiber Mesh Coating Improves the Mechanical Stability and Osseointegration of Titanium Implants

Microgroove and Collagen-poly(ε-caprolactone) Nanofiber Mesh Coating Improves the Mechanical Stability and Osseointegration of Titanium Implants

Bio-Interfaces Engineering Using Laser-Based Methods for Controlled Regulation of Mesenchymal Stem Cell Response In Vitro

Use of Polycaprolactone Electrospun Nanofibers as a Coating for Poly(methyl methacrylate) Bone Cement

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