TFF peptides and mucins are major components of dacryoliths

Paulsen, Friedrich; Schaudig, Ulrich; Fabian, Alexander; Ehrich, D.; Sel, Saadettin

doi:10.1007/s00417-005-0167-4

Cited by 40 publications

(43 citation statements)

References 30 publications

(44 reference statements)

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“…TFF2 is also ectopically secreted from a variety of mucous epithelia during stone diseases, such as nephrolithiasis, hepatolithiasis, dacryolithiasis, and cholecystolithiasis (135,136). Thus, TFF2, together with MUC6, would be a prime candidate for initiating the complex process of stone formation.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review)

Hoffmann

2015

International Journal of Oncology

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Abstract. The peptide TFF2 (formerly 'spasmolytic polypeptide'), a member of the trefoil factor family (TFF) containing two TFF domains, is mainly expressed together with the mucin MUC6 in the gastric epithelium and duodenal Brunner's glands. Pathologically, TFF2 expression is observed ectopically during stone diseases, chronic inflammatory conditions and in several metaplastic and neoplastic epithelia; most prominent being the 'spasmolytic polypeptide-expressing metaplasia' (SPEM), which is an established gastric precancerous lesion. TFF2 plays a critical role in maintaining gastric mucosal integrity and appears to restrain tumorigenesis in the stomach. Recently, porcine TFF2 has been shown to interact with the gastric mucin MUC6 and thus stabilize the gastric mucus barrier. On the one hand, TFF2 binds to MUC6 via non-covalent lectin interactions with the glycotope GlcNAcα1→4Galβ1→R. On the other hand, TFF2 is probably also covalently bound to MUC6 via disulfide bridges. Thus, implications for the complex multimeric assembly, cross-linking, and packaging of MUC6 as well as the rheology of gastric mucus are discussed in detail in this review. Furthermore, TFF2 is also expressed in minor amounts in the immune and nervous systems. Thus, similar to galectins, its lectin activity would perfectly enable TFF2 to form multivalent complexes and cross-linked lattices with a plethora of transmembrane glycoproteins and thus modulate different signal transduction processes. This could explain the multiple and diverse biological effects of TFF2 [e.g., motogenic, (anti)apoptotic, and angiogenic effects]. Finally, a function during fertilization is also possible for TFF domains because they occur as shuffled modules in certain zona pellucida proteins.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review)

Hoffmann

2015

International Journal of Oncology

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“…This suggests bacterial infection is one of the processes involved in the creation of dacryoliths. In addition, proteomic analysis revealed that the TFF peptide, considered as the predominant component in previous report [3] , was not a major component of the dacryoliths in our study. However, the possibility of the TFF peptide may not be excluded because no histological examination was performed in our study.…”

Section: Discussionmentioning

confidence: 59%

“…Paulsen et al [3] reported that trefoil factor (TFF) peptide and mucins are the major components of dacryoliths. Iliadelis et al [4] performed a histochemical analysis of dacryoliths in a series of DCR procedures.…”

Section: Introductionmentioning

confidence: 99%

Proteomic Analysis of Dacryoliths from Patients with or without Topical Rebamipide Treatment

Mano

Takimoto

et al. 2018

Biomed Hub

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Background : A dacryolith mainly contains organic material, but its specific protein content is unknown. We observed a unique dacryolith formation in patients with long-term use of rebamipide eye drops and tried to identify the differences in protein compositions of dacryoliths from patients with or without use of rebamipide eye drops using novel proteomic analysis. Methods: Dacryolith samples were obtained from 7 patients (4 samples were without rebamipide usage, 3 were with rebamipide usage) who underwent endo-dacryocystorhinostomy or lacrimal endoscopic surgery and were subjected to protein identification and metaproteomic analysis. Results: The proteomic analysis revealed that most core proteins of dac-

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“…Mucins and TFF peptides are structural components of precipitation extracted from the lacrimal passages. It has not yet been verified whether the presence of those substances is caused by their participation in precipitation forming initiative process or is a response to the existing pathological process [33]. …”

Section: Functional Anatomy Of the Lacrimal Pathwaysmentioning

confidence: 99%

Diagnostic imaging of the nasolacrimal drainage system. Part I. Radiological anatomy of lacrimal pathways. Physiology of tear secretion and tear outflow

Maliborski

Różycki

2014

Med Sci Monit

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Excessive watering of the eye is a common condition in ophthalmological practice. It may be the result of excessive production of tear fluid or obstruction and insufficiency of efferent tear pathways. The differentiation between obstruction and insufficiency of the lacrimal pathways is still clinically questionable. In the diagnostic process it is necessary to perform clinical tests and additional diagnostic imaging is often needed. Dacryocystography, with or without the extension of the dynamic phase or subtraction option, still remains the criterion standard for diagnostic imaging of the lacrimal obstruction. It may help to clarify the cause and exact place of the obstruction and provide information for further management, especially surgical treatment. Increasingly, new techniques are used in diagnostic imaging of the lacrimal tract, such as computed tomography, magnetic resonance, and isotopic methods.Adequate knowledge of the anatomy and physiology of the lacrimal system and the secretion and outflow of tears is the basis for proper diagnostic imaging. The purpose of this paper is to present the exact anatomy of the lacrimal system, with particular emphasis on the radiological anatomy and the current state of knowledge about the physiology of tear secretion and drainage.

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TFF peptides and mucins are major components of dacryoliths

Cited by 40 publications

References 30 publications

TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review)

TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review)

Proteomic Analysis of Dacryoliths from Patients with or without Topical Rebamipide Treatment

Diagnostic imaging of the nasolacrimal drainage system. Part I. Radiological anatomy of lacrimal pathways. Physiology of tear secretion and tear outflow

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