TFF1 gene expression in human medullary thyroid carcinoma

Wang, Da-Gong; Liu, Weihua; Lundy, Fionnuala; Pogue, Kathy M.; Cunningham, Rodat T.; Johnston, C.F.; Buchanan, K. D.

doi:10.1002/(sici)1096-9896(199804)184:4<408::aid-path1222>3.0.co;2-3

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…It has also been consistently demonstrated in C-cell hyperplasia and in all or nearly all medullary carcinomas. [17][18][19]21,22,25,[28][29][30][31] Only approximately 5% to 15% of anaplastic carcinomas have been found to be TTF-1 positive. 25,32 Two of the 4 cases of mucoepidermoid carcinoma of the thyroid that were investigated for TTF-1 expression were also found to be positive for this marker.…”

Section: Expression Of Ttf-1 In Thyroid Tumorsmentioning

confidence: 99%

Value of Thyroid Transcription Factor-1 Immunostaining in Tumor Diagnosis

Ordóñez¹

2012

Applied Immunohistochemistry &Amp; Molecular Morphology

130

116

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Thyroid transcription factor-1 (TTF-1) is a tissue-specific transcription factor that plays a critical role in the normal development of embryonic epithelial cells of the thyroid and lung. Because TTF-1 expression is highly restricted to epithelial tumors arising in these organs, it is, at present, one of the immunohistochemical markers most commonly used to assist in the differential diagnosis of carcinomas of the lung and thyroid. Recent studies, however, have reported that TTF-1 is not as specific for lung and thyroid carcinomas as was previously thought as it can be found to be expressed, although much less frequently, in some carcinomas arising in other organs, such as the ovaries, endometrium, colon, and breast, as well as in some tumors of the central nervous system. Even though this unexpected TTF-1 positivity has been reported more frequently with the recently available SPT24 anti-TTF-1 monoclonal antibody, it has also been shown to occur with the commonly used 8G7G3/1 clone, albeit in a lower percentage of cases. Despite these findings, TTF-1 remains a very useful immunohistochemical marker in diagnostic pathology.

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Section: Expression Of Ttf-1 In Thyroid Tumorsmentioning

confidence: 99%

Value of Thyroid Transcription Factor-1 Immunostaining in Tumor Diagnosis

Ordóñez¹

2012

Applied Immunohistochemistry &Amp; Molecular Morphology

130

116

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“…45 In prostate cancer, TFF1 has been detected in close association with neuroendocrine differentiation, as assessed by chromogranin A immunoreactivity, and was reported to be a useful diagnostic marker of neuroendocrine differentiation in prostate cancer 29. TFF1 is expressed both in the sporadic and hereditary form of human medullary thyroid carcinoma (MTC)48 and also in C-cell hyperplasia, in all probability a precursor of familial MTC,50 suggesting possible involvement in the pathogenesis of MTC. Interestingly, TFF1 protein in neuroendocrine cells was first described in the mucosal endocrine cell hyperplasia which accompanies small bowel Crohn’s disease 51.…”

Section: Expression In Normal and Pathological Conditionsmentioning

confidence: 99%

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“…Moreover, TFF1 has been detected in micrometastases in breast cancer and has been proposed as a valuable molecular marker of micrometastases 33 . Other tumors such as stomach, 20 colon, 27 pancreas 26 and medullary thyroid carcinomas 22 have shown TFF1 expression in metastatic deposits. Thus TFF1 can be considered as both a promoter of tumor invasion and metastasis and a marker of response to hormonal therapy.…”

Section: Introductionmentioning

confidence: 99%

“…16,17 In pathological conditions, TFF1 is expressed at high levels in inflammatory diseases such as in cholecystitis 18 and inflammatory bowel disease. 19 TFF1 is also expressed in various types of mucin-producing cancers such as stomach, 20 lung, 21 thyroid, 22 breast, 11 ovarian, 23 endometrium, 24 prostate, 25 pancreas, 26 colon, 27 gall bladder 18 and hepatolithiasisassociated CCA. 28,29 In cancer, TFF1 is considered as a metastasis stimulating agent due to its motogenic effect.…”

Section: Introductionmentioning

confidence: 99%