TGF-β expression and wound tensile strength after simple interrupted suturing and zip surgical skin closure (IN VIVO study)

Abstract

Primary healing occurs when both edges of the adjacent incision wound meet. To achieve primary healing, bringing the wound edges closer is generally done by suturing. At present comes one of the methods of skin incision closure without involving sutures called zip surgical skin closure. As an indicator of commonly used wound healing, tensile strength is produced by collagen that involves TGF-β in its production. This study was aimed to observe the expression of TGF-β and tensile strength of the skin incision-post wound using simple interrupted suturing or zip surgical skin closure. An experimental laboratory, this study used Sprague Dawley rats with the predetermined inclusion criteria. Thirty-six rats were applied with 3 cm-dorsal skin incisions after which they were divided into 2 groups, group 1 received simple interrupted suturing and group 2 received zip surgical skin closure. TGF-β examination was performed with BS-0086R polyclonal antibodies and wound tensile strength was observed on day 3, 7 and 14. The independent t -test showed that the tensile strength of the zip surgical skin closure group was higher and was significant as observed on day 7 (p = 0.000) than that of the simple interrupted suturing group. TGF-β expression in the zip surgical skin closure group was found more numerous and significant on day 7 and 14 than that of in the simple interrupted group, (p = 0.025) and (p = 0.032) respectively. Conclusion. Skin incision-post wound healing with zip surgical skin closure is better and shows higher tensile strength and more numerous TGF-β expressions than simple interrupted suturing.

A Prospective, Randomized, Controlled Comparison of Adhesive Wound Closure Devices in an Orthopaedic Patient

“…16 In addition, two biomechanical studies showed that the Zip surgical skin closure system performed superiorly to sutures and staples, holding the wound intact with reduced shear forces and higher tensile strength, reducing propensity for postsurgical scarring. 15,24 Clozex has been noted to have a similar beneficial profile in the literature. Kuo et al 12 conducted a randomized, controlled trial comparing Clozex with a simple running 4-0 Prolene suture among patients undergoing excision of cutaneous skin lesions.…”

“… 16 In addition, two biomechanical studies showed that the Zip surgical skin closure system performed superiorly to sutures and staples, holding the wound intact with reduced shear forces and higher tensile strength, reducing propensity for postsurgical scarring. 15 , 24 …”

“…These products are FDA-approved to promote skin apposition while reducing tension during the healing process. 15 They are safe and effective treatment options and have been adopted in many practices. [16][17][18] This study was developed to directly compare Zip, Clozex, and a typical closure method using a running 3-0 Prolene suture and to determine which provides the best cosmetic result using the Stony Brook Scar Evaluation Scale (SBSES).…”

“…These products are FDA-approved to promote skin apposition while reducing tension during the healing process. 15 They are safe and effective treatment options and have been adopted in many practices. 16 - 18 …”

The Unprecedented Biodegradable Polyzwitterion: A Removal‐Free Patch for Accelerating Infected Diabetic Wound Healing

“…[21,30] In the early stage of wound healing, the tensile strength of wound was generally under 17 kPa. [31] At this stage of treatment, dressings with too high adhesion strength are prone to cause trauma and pain to the patient, particularly those with fragile skin, especially the elderly and children. [32] We noted that the PCBDS patch could be firmly bonded to the surface of pork skin and maintained its position without detachment after various deformations such as bending and twisting (Figure 3F).…”