TGF-β/Smad signaling pathway regulates Th17/Treg balance during Echinococcus multilocularis infection

Pang, Nannan; Zhang, Fengbo; Ma, Xiumin; Zhu, Yuejie; Zhao, Hui; Xin, Yan Ping; Wang, Song; Chen, Zhaolun; Wen, Hao; Ding, Jianbing

doi:10.1016/j.intimp.2014.02.038

Cited by 70 publications

(49 citation statements)

References 51 publications

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“…Furthermore, IL-17R-deficient mice were associated with reduced production of the chemokine MIP-2 along with the suboptimal levels of neutrophil recruitment and higher parasitic load as compared with wild-type counterparts 111 . Additionally, during echinococcosis, IL-17 plays a crucial immune protective role by regulating the Tregs which are associated with tolerance during infection 112 . In contrast, in human cutaneous leishmaniasis 113– 115 and Eimeria tenella infection in chickens 116 , IL-17 contributed to the pathology through excessive inflammation and subsequent tissue damage.…”

Section: Role Of Il-17 In Parasitic Infectionmentioning

confidence: 99%

Yin and yang of interleukin-17 in host immunity to infection

Das

Khader

2017

F1000Res

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The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral. The IL-17R signaling and downstream pathways mediate induction of proinflammatory molecules which participate in control of these pathogens. However, the production of IL-17 can also mediate pathology and inflammation associated with infections. In this review, we will discuss the yin-and-yang roles of IL-17 in host immunity to pathogens.

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Section: Role Of Il-17 In Parasitic Infectionmentioning

confidence: 99%

Yin and yang of interleukin-17 in host immunity to infection

Das

Khader

2017

F1000Res

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“…Phosphorylated Smads translocate to the nucleus where they function as transcription factors, initiating target gene transcription (Banas et al, 2006). The relationship between the TGF-␤/Smad pathway, and especially the expression of Smad7, which may play a regulatory role in the system, and clinical and/or pathological features of AE in experimental models as well as in human AE has been exploratively addressed by Wang et al (2013) and recently also by Pang et al (2014). Other studies on the immunopathology of AE revealed that CD4+CD25+ Treg cells play a critical role in human AE by blunting immune responses to specific antigens, or by suppressing the secretion of proinflammatory cytokines, especially through IL-10 and TGF-␤1 (Hübner et al, 2006).…”

Section: Biology and Immunology Of Susceptibility Versus Resistance Imentioning

confidence: 99%

Susceptibility versus resistance in alveolar echinococcosis (larval infection with Echinococcus multilocularis)

Gottstein

Wang

Boubaker

et al. 2015

Veterinary Parasitology

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Epidemiological studies have demonstrated that the majority of human individuals exposed to infection with Echinococcus spp. eggs exhibit resistance to disease as shown by either seroconversion to parasite--specific antigens, and/or the presence of 'dying out' or 'aborted' metacestodes, not including hereby those individuals who putatively got infected but did not seroconvert and who subsequently allowed no development of the pathogen. For those individuals where infection leads to disease, the developing parasite is partially controlled by host immunity. In infected humans, the type of immune response developed by the host accounts for the subsequent trichotomy concerning the parasite development: (i) seroconversion proving infection, but lack of any hepatic lesion indicating the failure of the parasite to establish and further develop within the liver; or resistance as shown by the presence of fully calcified lesions; (ii) controlled susceptibility as found in the "conventional" alveolar echinococcosis (AE) patients who experience clinical signs and symptoms approximately 5-15 years after infection, and (iii) uncontrolled hyperproliferation of the metacestode due to an impaired immune response (AIDS or other immunodeficiencies). Immunomodulation of host immunity toward anergy seems to be triggered by parasite metabolites. Beside immunomodulating IL-10, TGFβ-driven regulatory T cells have been shown to play a crucial role in the parasite-modulated progressive course of AE. A novel CD4+CD25+ Treg effector molecule FGL2 recently yielded new insight into the tolerance process in Echinococcus multilocularis infection.

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“…The cellular programs are implemented, the inflammatory activation of immune-competent cells decreases, and the reparative processes due to the polarization of macrophages towards M2 phenotype are amplified [7, 8, 22, 26]. …”

Section: Resultsmentioning

confidence: 99%

“…Thus, the observed changes of the intracellular content of the factors such as CREB, AKT, SMAD, and p53 allow speaking about the possibility of switching cellular strategy from the implementation of proinflammatory responses to specific regulatory responses under the influence of the resonant microwaves at 1 GHz in the course of the activity reduction of stress-activated and mitogen-activated signaling pathways [6, 7, 22, 25, 35]. Recovery of normal cell reactivity will contribute to the realization of the effects CREB, aimed at improving the plasticity of the cells to specific signals, making the cell adapt to the new conditions.…”

Section: Resultsmentioning

confidence: 99%

The State of Intracellular Molecular Regulators during the Reconvalescence of Community-Acquired Pneumonia under the Influence of Microwaves at 1 GHz

et al. 2018

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We evaluated the levels of protein p53, retinoblastoma protein (RB), β-catenin, SMAD2, protein kinases AKT and focal adhesion kinase (FAK), and transcription factor CREB using ELISA in mononuclear leukocytes of patients with community-acquired pneumonia on days 15–17 of the disease. The research results showed that the subclinical immune-inflammatory process was characterized by a higher content of β-catenin by 19.8%, CREB by 23.3%, RB protein by 14.7%, increased phosphorylation level of protein kinase FAK by 19.8%, АKТ1 at serine-473 by 65.6%, and RB by 13.7%. In the cells, there was a decrease in p53 of 15.7%, SMAD2 of 16.9%, and protein kinase АKТ1 of 31.2%. Three hours after 1-GHz microwave irradiation, MNCs displayed a statistically significant increase in their content of the p53 protein of 20.0‰, RB of 9.35‰, β-catenin of 10.9‰, protein kinase FAK of 10.0‰, and CREB of 8.55‰. A day after a single irradiation of the cultures of whole blood cells, in irradiated cells compared to nonirradiated control, we observed a statistically significant increase in the content of p53 of 24.2‰, β-catenin of 15.1‰, SMAD2 of 20.4‰, RB of 9.8‰, as well as a reduction of the initially elevated levels of protein kinase AKT1 of 25.1‰, its phosphorylated form at serine-473 of 16.5‰, and a decrease in the phosphorylated form of the transcription factor CREB at serine-133 of 4.1‰. The research results indicate that a low-intensity microwave frequency of 1 GHz can be considered as a factor in molecular immune rehabilitation in conditions of community-acquired pneumonia.

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TGF-β/Smad signaling pathway regulates Th17/Treg balance during Echinococcus multilocularis infection

Cited by 70 publications

References 51 publications

Yin and yang of interleukin-17 in host immunity to infection

Yin and yang of interleukin-17 in host immunity to infection

Susceptibility versus resistance in alveolar echinococcosis (larval infection with Echinococcus multilocularis)

The State of Intracellular Molecular Regulators during the Reconvalescence of Community-Acquired Pneumonia under the Influence of Microwaves at 1 GHz

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