TGFβ1‐Smad3‐Jagged1‐Notch1–Slug signaling pathway takes part in tumorigenesis and progress of tongue squamous cell carcinoma

Zhang, Tong‐Han; Liang, Liyang; Liu, Xiaoling; Wu, Jinlong; Chen, Jueyao; Su, Kui; Zheng, Qiaoyi; Huang, Hongzhang; Liao, Guiqing

doi:10.1111/jop.12406

Cited by 28 publications

(26 citation statements)

References 41 publications

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“…Nearly 50% of OTSCC patients have lymph node metastases, indicating that OTSCC cells have strong invasive and migratory capacities. For cellular progression, epithelial cancer cells must undergo increased invasive and migratory abilities during EMT, which is an essential step for metastatic spreading (19,20). EMT is a multi-step process where epithelial cells acquire a mesenchymal phenotype which is characterized by enhanced motility ability, downregulation of epithelial proteins including E-cadherin, claudins and α-catenin, and overexpression of mesenchymal phenotype proteins, such as vimentin, N-cadherin and fibronectin.…”

Section: Discussionmentioning

confidence: 99%

“…HIF-1 is composed of αβ heterodimers; expression of the α-subunit is tightly regulated by oxygen, whereas the β-subunit is constitutively expressed (18). Numerous studies have shown that HIF-1α overexpression is frequently observed in human cancers and is associated with metastasis of several types of solid types of carcinoma, including breast carcinoma, chondrosarcoma, colorectal adenocarcinoma and head and neck cancer (19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

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FNDC3B promotes epithelial-mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment

et al. 2018

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The primary reasons for the treatment failure of patients with oral tongue squamous cell carcinoma (OTSCC) are metastasis and tumor recurrence. Identifying the exact mechanisms underlying metastasis is a key point in improving patient prognosis. It has been reported that a hypoxic microenvironment plays an important role during the metastasis of malignancies. We found that the expression of fibronectin type III domain containing 3B (FNDC3B) is positively correlated with lymph node metastasis and advanced cTNM stage of OTSCC by IHC assay and correlation analysis. Furthermore, we found that knockdown of FNDC3B could suppress the migratory and invasive abilities of OTSCC cells. In addition, treating OTSCC cells with CoCl2 (a hypoxia mimetic agent) upregulated the mRNA and protein expression of FNDC3B via HIF-1α. Moreover, the resultant increase in FNDC3B expression significantly induced epithelial-mesenchymal transition (EMT) in OTSCC cells. The present study elucidated the important role played by FNDC3B in OTSCC metastasis and indicates FNDC3B as a potential target for the treatment of OTSCC metastasis. However, many questions remain to be explored.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

FNDC3B promotes epithelial-mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment

et al. 2018

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“…Tongue squamous cell carcinoma (TSCC) was the most frequent type of oral squamous cell carcinoma (OSCC) and was famous for its high ability of metastasis and proliferation . TSCC usually leads to dysfunction of speech, mastication and deglutition .…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‐137 suppresses tongue squamous carcinoma cell proliferation, migration and invasion

et al. 2016

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“…The TGF- β 1/smad3 signaling pathway, a critical regulator of apoptosis, mediates important biological processes including tumorigenesis [ 38 ]. Yu et al [ 39 ] reported that genistein inhibits mouse colon cancer via regulating TGF- β 1/smad pathway.…”

Section: Discussionmentioning

confidence: 99%

Curcumin Inhibits Hepatocellular Carcinoma via Regulating miR‐21/TIMP3 Axis

Wei

Liu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background/Aim. Curcumin exhibits anticancer effects against various types of cancer including hepatocellular carcinoma (HCC). miR-21 has been reported to be involved in the malignant biological properties of HCC. However, whether miR-21 plays a role in curcumin-mediated treatment of HCC is unknown. The purpose of this study was to identify the potential functions and mechanisms of miR-21 in curcumin-mediated treatment of HCC. Methods. The anticancer effects of curcumin were assessed in vivo and in vitro. The underlying mechanism of miR-21 in curcumin-mediated treatment of HCC was assessed by quantitative real-time PCR (RT-qPCR), western blot, and Dual-Luciferase Reporter assays. Results. The present study revealed that curcumin suppressed HCC growth in vivo and inhibited HCC cell proliferation and induced cell apoptosis in a dose-dependent manner in vitro. Meanwhile, the curcumin treatment can downregulate miR-21 expression, upregulate TIMP3 expression, and inhibit the TGF-β1/smad3 signaling pathway. miR-21 inhibition enhanced the effect of curcumin on cell proliferation inhibition, apoptosis, and TGF-β1/smad3 signaling pathway inhibition in HepG2 and HCCLM3 cells. It demonstrated that TIMP3 was a direct target gene of miR-21. Interestingly, the effect of miR-21 inhibition on cell proliferation, apoptosis, and TGF-β1/smad3 signaling pathway in HepG2 and HCCLM3 cells exposed to curcumin was attenuated by TIMP3 silencing. Conclusion. Taken together, the present study suggests that miR-21 is involved in the anticancer activities of curcumin through targeting TIMP3, and the mechanism possibly refers to the inhibition of TGF-β1/smad3 signaling pathway.

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TGFβ1‐Smad3‐Jagged1‐Notch1–Slug signaling pathway takes part in tumorigenesis and progress of tongue squamous cell carcinoma

Cited by 28 publications

References 41 publications

FNDC3B promotes epithelial-mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment

FNDC3B promotes epithelial-mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment

MicroRNA‐137 suppresses tongue squamous carcinoma cell proliferation, migration and invasion

Curcumin Inhibits Hepatocellular Carcinoma via Regulating miR‐21/TIMP3 Axis

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