TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

Perino, Alessia; Pols, Thijs W.H.; Nomura, Mitsunori; Stein, Sokrates; Pellicciari, Roberto; Schoonjans, Kristina

doi:10.1172/jci76289

Cited by 191 publications

(147 citation statements)

References 95 publications

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“…TGR5 is also highly expressed on immune cells (25,26) and has been suggested to have antiinflammatory effects (41). Indeed, recent studies have shown that obese mice lacking TGR5 in macrophages exhibit enhanced adipose inflammation and enhanced insulin resistance compared with control obese animals, while pharmacological activation of TGR5 can decrease LPS-induced chemokine expression in macrophages (42).…”

Section: Discussionmentioning

confidence: 99%

Antibiotic effects on gut microbiota and metabolism are host dependent

Fujisaka¹,

Ussar²,

Clish³

et al. 2016

Journal of Clinical Investigation

137

123

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Section: Discussionmentioning

confidence: 99%

Antibiotic effects on gut microbiota and metabolism are host dependent

Fujisaka¹,

Ussar²,

Clish³

et al. 2016

Journal of Clinical Investigation

137

123

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“…An increasing body of evidence shows TGR5's important role in energy homeostasis, glucose metabolism (Thomas et al 2009) and the modulation of immune functions (Perino et al 2014). In addition, recently published data also demonstrated TGR5 expression in pancreatic b cells, with a direct effect on insulin secretion (Kumar et al 2012) (in a similar manner as described above for FXR) and also in cardiomyocytes (Desai et al 2010).…”

Section: Cellular Targets Of Bamentioning

confidence: 73%

“…TGR5 (GPBAR1), a member of the rhodopsin-like subfamily of G protein-coupled receptors, is expressed in the enteroendocrine small-intestinal cells as well as in the thyroid gland, brown adipose tissue (Zhou & Hylemon 2014), macrophages (Perino et al 2014) and in many other organs (Duboc et al 2014). An increasing body of evidence shows TGR5's important role in energy homeostasis, glucose metabolism (Thomas et al 2009) and the modulation of immune functions (Perino et al 2014).…”

Section: Cellular Targets Of Bamentioning

confidence: 99%

The role of bile acids in metabolic regulation

Vı́tek¹,

Haluzı́k²

2016

Journal of Endocrinology

109

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Bile acids (BA), long believed to only have lipid-digestive functions, have emerged as novel metabolic modulators. They have important endocrine effects through multiple cytoplasmic as well as nuclear receptors in various organs and tissues. BA affect multiple functions to control energy homeostasis, as well as glucose and lipid metabolism, predominantly by activating the nuclear farnesoid X receptor and the cytoplasmic G protein-coupled BA receptor TGR5 in a variety of tissues. However, BA also are aimed at many other cellular targets in a wide array of organs and cell compartments. Their role in the pathogenesis of diabetes, obesity and other 'diseases of civilization' becomes even more clear. They also interact with the gut microbiome, with important clinical implications, further extending the complexity of their biological functions. Therefore, it is not surprising that BA metabolism is substantially modulated by bariatric surgery, a phenomenon contributing favorably to the therapeutic effects of these surgical procedures. Based on these data, several therapeutic approaches to ameliorate obesity and diabetes have been proposed to affect the cellular targets of BA.

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“…TGR5 has been recently reported to be expressed in macrophage and reduce inflammation in adipose tissue using macrophage-specific TGR5 knockout mouse model (Perino et al 2014). This recent study reported that adipose tissue from obese mice lacking TGR5 in macrophages exhibited enhanced inflammation, increased chemokine expression, and higher macrophage numbers in adipose tissue, leading to insulin resistance.…”

Section: Tgr5 In Immune Cells: Macrophages and Kupffer Cellsmentioning

confidence: 96%

Essential roles of bile acid receptors FXR and TGR5 as metabolic regulators

Jacinto

Fang

2014

Animal Cells and Systems

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Alterations of bile acid (BA) metabolism in type II diabetes (T2D) have revealed a link between BAs and metabolic homeostasis. The BA receptors farnesoid X receptor (FXR) and G-protein coupled BA receptor 1 (TGR5) both have shown to regulate lipid, glucose, and energy metabolism, rendering them potential therapeutic targets for T2D therapy. Astonishingly, BA signaling is vital as it has known to be a positive factor for beneficial improvements in vertical sleeve gastrectomy surgery, in turn making these BA receptors beneficial tools in therapeutic targets for T2D. These metabolic regulators: FXR and TGR5 are essential modulators in the metabolic system, which affect the human machinery and will be the focus of this review.

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TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

Cited by 191 publications

References 95 publications

Antibiotic effects on gut microbiota and metabolism are host dependent

Antibiotic effects on gut microbiota and metabolism are host dependent

The role of bile acids in metabolic regulation

Essential roles of bile acid receptors FXR and TGR5 as metabolic regulators

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