TH-17 cells in rheumatoid arthritis

Shahrara, Shiva; Huang, Qi; Mandelin, Arthur M.; Pope, Richard M.

doi:10.1186/ar2477

Cited by 180 publications

(144 citation statements)

References 27 publications

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“…The identification of this new subtype of th17 cell has prompted renewed interest in IL-17 biology. IL-17 plays an important role in inflammation, and is critical in host defense against infectious disease, allergy, and autoimmune diseases such as rheumatoid arthritis and inflammatory bowel diseases, which include crohn's disease and ulcerative colitis (8,9). Interestingly, Il-17 also has been reported to be up-regulated in Helicobacter pylori (Hp) infected gastric mucosa.…”

Section: Introductionmentioning

confidence: 99%

Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric cancer

Iida

Itō

Katsuda³

et al. 2011

Oncol Rep

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Abstract. recently, a subset of Il-17 producing t cells distinct from th1 or th2 cells has been described as key players in inflammation and autoimmune diseases as well as cancer development. In this study, we investigated the expression level of Il-17 and t helper 17 (th17)-related cytokines in gastric cancer tissues and assessed the association of their expression with angiogenesis and their clinicopathological parameters. tumor and adjacent normal tissues were obtained from 82 patients with gastric cancer. Il-17, Il-21 and Il-23 mRNA expression levels were quantified by real-time RT-PCR. Th17 infiltration, microvessel density and neutrophil infiltration in tumor tissues were examined by immunohistochemistry and double immunofluorescence histochemistry. Expression of IL-17, IL-21 and IL-23 mRNA was found to be significantly up-regulated in tumor tissues compared with adjacent normal tissues. the expression level of Il-17 mrnA strongly and positively correlated with that of Il-21 mrnA in tumor tissue. the number of vascular endothelial cells and infiltrating neutrophils was significantly larger in tumors expressing a high level of Il-17 mrnA than in tumors expressing a low level of Il-17 mrnA. In tumor tissues most cD4 + cells were stained with anti-Il-17 antibody. the expression level of Il-17 mrnA in gastric tumors was associated with the depth of the tumors, lymph-vascular invasion and lymph node involvement, suggesting that Il-17 obviously was related to tumor progression. Il-17 and Il-21, which regulates Il-17, would be potential therapeutic targets for the treatment of gastric cancer.

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Section: Introductionmentioning

confidence: 99%

Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric cancer

Iida

Itō

Katsuda³

et al. 2011

Oncol Rep

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“…Both of these cytokines have been implicated in autoimmune diseases, and production of each has been described in the synovial tissue and synovial fluid of patients with RA (20,21). The frequency and number of IL-4ϩ cells were not increased in the lymph nodes and paws of immunized mice, nor did they differ between wild-type and CXCR6 Ϫ/Ϫ mice ( Figures 3A-C).…”

mentioning

confidence: 97%

Regulation of Cytokine Polarization and T Cell Recruitment to Inflamed Paws in Mouse Collagen‐Induced Arthritis by the Chemokine Receptor CXCR6

Slauenwhite

Gebremeskel

Doucette

et al. 2014

Arthritis & Rheumatology

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Objective. The chemokine receptor CXCR6 is highly expressed on lymphocytes isolated from the synovium of patients with rheumatoid arthritis, psoriatic arthritis, or juvenile idiopathic arthritis, suggesting that CXCR6 regulates immune cell activation or infiltration into arthritic joints. This study was undertaken to examine the role of CXCR6 in T cell activation and arthritis development.Methods. A collagen-induced arthritis model was used to examine arthritis development in wild-type and CXCR6 ؊/؊ mice. CXCR6 expression, lymphocyte accumulation, and intracellular cytokine production were examined by flow cytometry. Collagen-specific antibodies were measured in the serum. Collagen-specific recall responses were examined in vitro via proliferation and cytokine release assays. T cell homing to inflamed joints was examined using competitive adoptive transfer of dye-labeled lymphocytes from wild-type and CXCR6 ؊/؊ mice.Results. The numbers of CXCR6؉ T cells were increased in the paws and draining lymph nodes of arthritic mice. The incidence of arthritis, disease severity, extent of T cell accumulation, and levels of collagenspecific IgG2a antibodies were significantly reduced in CXCR6 ؊/؊ mice compared to wild-type mice. Conclusion. These experiments demonstrate that CXCR6 plays important roles in the pathogenesis of arthritis through its effects on both T cell cytokine polarization and homing of T cells to inflamed joints.

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“…Several studies have demonstrated higher expression of IL-27 in RA synovial tissue and in RA synovial fluid macrophages as compared with controls (4,5). The levels of IL-27 messenger RNA are significantly higher in RA synovial fluid monocytes than in those from controls (4).…”

Section: Interleukin-27: a Master Regulator In Inflammation Ursula Fementioning

confidence: 97%

“…Initial studies examining IL-27 function demonstrated a role in promoting early stages of activation of naive CD4ϩ T and Th1 cell differentiation (1,3,4). IL-27 can synergize with IL-12 to promote production of interferon-␥ (IFN␥) by CD4ϩ, CD8ϩ, and NK T cells (2).…”

Section: Interleukin-27: a Master Regulator In Inflammation Ursula Fementioning

confidence: 99%

“…IL-27 is expressed mainly on activated macrophages and dendritic cells; in contrast, IL-27 receptor (IL-27R) is widely expressed and is detected on naive T cells, natural killer (NK) cells, monocytes, mast cells, vascular endothelium, keratinocytes, activated B cells, Langerhans' cells, and dendritic cells (1). IL-27 is expressed at sites of inflammation in autoimmune/inflammatory diseases, such as RA, PsA, systemic sclerosis (SSc), inflammatory bowel disease (IBD), multiple sclerosis, and sarcoidosis (1,(4)(5)(6). IL-27 is predominantly produced shortly after stimulation of antigen-presenting cells by Toll-like receptor (TLR) ligands or infectious agents (1,2).…”

Section: Interleukin-27: a Master Regulator In Inflammation Ursula Fementioning

confidence: 99%

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Interleukin‐27: A master regulator in inflammation

Fearon¹

2011

Arthritis & Rheumatism

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TH-17 cells in rheumatoid arthritis

Cited by 180 publications

References 27 publications

Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric cancer

Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric cancer

Regulation of Cytokine Polarization and T Cell Recruitment to Inflamed Paws in Mouse Collagen‐Induced Arthritis by the Chemokine Receptor CXCR6

Interleukin‐27: A master regulator in inflammation

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