2008
DOI: 10.1002/eji.200838541
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Th memory for interleukin‐17 expression is stable in vivo

Abstract: Based on the memory for the re-expression of certain cytokine genes, different subsets of Th cells have been defined. In Th type 1 (Th1) and Th2 memory lymphocytes, the genes for the cytokines interferon-c and interleukin (IL)-4 are imprinted for expression upon restimulation by the expression of the transcription factors T-bet and GATA-3, respectively, and epigenetic modification of the cytokine genes. In Th17 cells, IL-17 expression is dependent on the transcription factors RORct and RORa. Here, we analyze t… Show more

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Cited by 138 publications
(151 citation statements)
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“…3D). IL-12, as previously shown [17], did not lead to significant induction of IFN-g expression (Fig. 3A), nor upregulation of T-bet expression or changes in RORgt expression (Fig.…”
supporting
confidence: 84%
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“…3D). IL-12, as previously shown [17], did not lead to significant induction of IFN-g expression (Fig. 3A), nor upregulation of T-bet expression or changes in RORgt expression (Fig.…”
supporting
confidence: 84%
“…1A, upper panel), IL-17 expressing cells directly isolated ex vivo maintained IL-17 expression and could not be induced to express IFN-g in the presence of IL-12 (Fig. 1A, lower panel) [17,19]. To identify the molecular mechanism of refraction of in vivo generated Th17 cells to conversion by IL-12, we here compared the expression of genes relevant for IL-12 signaling by Th17 cells generated in vitro, and CD4 1 T cells isolated directly ex vivo according to secretion of IL-17, using the cytometric cytokine secretion assay for IL-17, as described earlier [17].…”
Section: Resultsmentioning
confidence: 95%
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