TH1-directed modulation of in vitro cytokine production in human peripheral blood mononuclear cells by styrene-7.8-oxide

Merker, Georg H.; Metzner, G; Raabe, F

doi:10.1016/j.toxlet.2005.06.014

Cited by 12 publications

(9 citation statements)

References 20 publications

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“…However, there were limited studies focusing on the association between indoor decoration and PCOS [13]. It was found that organic solvents, the most important constituents for indoor decoration, had a negative influence on glucose metabolism impairment [44,45]. Hundreds of chemicals were detected in organic solvents that could activate tumor necrosis factor α (TNFα), one of the most famous proinflammatory cytokines, which resulted excessive hepatic glucose formation, inhibited muscular glucose uptake, and impaired insulin sensitivity [46,47] through different pathways [47][48][49].…”

Section: Discussionmentioning

confidence: 99%

Lifestyle and environmental contributions to ovulatory dysfunction in women of polycystic ovary syndrome

et al. 2020

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Background: Polycystic ovary syndrome (PCOS) is the most common reason of anovulatory infertility. Environmental factor is one of the main causes of PCOS, but its contribution to ovulatory dysfunction in PCOS remains unknown. Methods: A total of 2217 infertile women diagnosed as PCOS according to Rotterdam criteria were recruited, including 1979 women with oligo-anovulation (OA group) and 238 women with normal-anovulation (non OA group). Besides, 279 healthy control women of reproductive age were enrolled as controls. Results: Frequencies of snoring (PCOS-OA group, PCOS-non-OA group, control group: 29.30% vs 18.10% vs 11.50%, P < 0.01), smoking (37.70% vs 28.10% vs 12.20%, P < 0.01), plastic tableware usage (38.30% vs 28.10% vs 25.40%, P < 0.01) and indoor decoration (32.10% vs 24.80% vs 16.80%, P < 0.01) were highest in PCOS-OA group. After adjusted for multivariable, difference remained significant between PCOS-OA group and the other two groups. PCOS-OA women preferred a meat favorable diet compared to PCOS-non-OA group (54.60% vs 41.30%, P < 0.01). There was no difference between three groups in exercise, frequency of insomnia, and alcohol consumption. Conclusions: Smoking, snoring, hyper-caloric diet, plastic tableware usage and indoor decoration were found to be associated with an increased risk for ovulatory dysfunction in women suffering from PCOS.

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Section: Discussionmentioning

confidence: 99%

Lifestyle and environmental contributions to ovulatory dysfunction in women of polycystic ovary syndrome

et al. 2020

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“…Many toxic chemicals, together with organic solvents to which humans are occupationally or non-occupationally exposed, having its physicochemical characteristics with different absorption routes and target organs. These have been confirmed to have toxicity in many organs (Xiao and Levin 2000) including the liver (Warnes et al 1999), hematopoietic organs (Natelson 2007), nervous system (White and Proctor 1997), immune endocrinological system (Wichmann et al 2005), kidney, cardiovascular system, skin, mucosa, and reproductive organs, and body homeostasis maintenance function (Merker et al 2006). The short term problems which can occur in shoe workers are irritation of the eyes, nose and throat, headache, dizziness, and confusion ( Ukai et al 1993, Ukai et al 1994.…”

Section: Introductionmentioning

confidence: 99%

Biochemical and Hematological Analysis after Exposure to Hazardous Materials during Shoe Making

Khan

Sultan

Rahman

2013

JBLS

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“…Diverse hazardous chemicals, including organic solvents that humans are occupationally or non-occupationally exposed to, have their own physicochemical characteristics with various absorption routes and target organs. They have been demonstrated to cause toxicity in various organs [1] including the liver [2,3], hematopoietic organs [4], nervous system [5], immunoendocrinological system [6], kidney, cardiovascular system, skin, mucosa, and reproductive organs, and have been reported to decrease or damage the body homeostasis maintenance function [7]. …”

Section: Introductionmentioning

confidence: 99%

The Effects of Long-Term, Low-Level Exposure to Monocyclic Aromatic Hydrocarbons on Worker's Insulin Resistance

Won

Heo

et al. 2011

Safety and Health at Work

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ObjectivesThis study was designed to investigate whether long-term, low-level exposure to monocyclic aromatic hydrocarbons (MAHs) induced insulin resistance.MethodsThe subjects were 110 male workers who were occupationally exposed to styrene, toluene, and xylene. One hundred and ten age-matched male workers who had never been occupationally exposed to organic solvents were selected as a control group. Cytokines, which have played a key role in the pathogenesis of insulin resistance, and oxidative stress indices were measured. Assessment of exposure to MAHs was performed by measuring their ambient levels and their urinary metabolites in exposed workers, and the resulting parameters between the exposed group and non-exposed control groups were compared.ResultsThere was no significant difference in general characteristics and anthropometric parameters between the two groups; however, total cholesterol, fasting glucose, fasting insulin, and homeostasis model assessment of insulin resistance levels were significantly higher in the exposed group. Phenylglyoxylic acid levels showed significant association with tumor necrosis factor-α, total oxidative status, and oxidative stress index via multiple linear regression analysis. Further, there was a negative correlation between methylhippuric acid levels and total anti-oxidative capacity, and there was a significant relationship between MAHs exposure and fasting glucose levels, as found by multiple logistic regression analysis (odds ratio = 3.95, 95% confidence interval = 1.074-14.530).ConclusionThis study indicated that MAHs increase fasting glucose level and insulin resistance. Furthermore, these results suggested that absorbing the organic solvent itself and active metabolic intermediates can increase oxidative stress and cytokine levels, resulting in the changes in glucose metabolism and the induction of insulin resistance.

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TH1-directed modulation of in vitro cytokine production in human peripheral blood mononuclear cells by styrene-7.8-oxide

Cited by 12 publications

References 20 publications

Lifestyle and environmental contributions to ovulatory dysfunction in women of polycystic ovary syndrome

Lifestyle and environmental contributions to ovulatory dysfunction in women of polycystic ovary syndrome

Biochemical and Hematological Analysis after Exposure to Hazardous Materials during Shoe Making

The Effects of Long-Term, Low-Level Exposure to Monocyclic Aromatic Hydrocarbons on Worker's Insulin Resistance

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