2004
DOI: 10.1002/ajh.10443
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Th1/Th2 cytokine profiles and their relationship to clinical features in patients following nonmyeloablative allogeneic stem cell transplantation

Abstract: An imbalance in helper T-cell type 1 (Th1) and type 2 (Th2) cytokines is suggested to play an important role in the pathogenesis of acute graft-versus-host disease (aGVHD). The aim of this study was to investigate the cytokine bias acquired by T cells after transplantation and its possible influence on relapse of original malignancy. Cytokine levels by peripheral CD4 and CD8 T cells were tested at various pre-and post-transplant time points with fluorescein isothiocyanate-based intracellular cytokine assay aft… Show more

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Cited by 18 publications
(8 citation statements)
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“…↓CD4+IFN+ and ↓CD8+IFN+ as indicators of relapse ↑CD4+IFN+ and ↑CD8+IFN+ as indicators of aGVHD [12] SOT Therapeutic immunodefficiency is dependant on drug dose and duration of treatment [27] CMV-CD8+ as predictors of CMV viremia, disease severity and relapse [28] ↓CMV-CD8+CD69+IFN+ as predictor of CMV infection in SOT patients (kidney and liver) [29] 1B), denying the assessment of intracellular colocalization of multiple cytokines. However, this issue can be easily avoided in future research by using customized antibodies instead.…”
Section: Nstmentioning
confidence: 99%
See 1 more Smart Citation
“…↓CD4+IFN+ and ↓CD8+IFN+ as indicators of relapse ↑CD4+IFN+ and ↑CD8+IFN+ as indicators of aGVHD [12] SOT Therapeutic immunodefficiency is dependant on drug dose and duration of treatment [27] CMV-CD8+ as predictors of CMV viremia, disease severity and relapse [28] ↓CMV-CD8+CD69+IFN+ as predictor of CMV infection in SOT patients (kidney and liver) [29] 1B), denying the assessment of intracellular colocalization of multiple cytokines. However, this issue can be easily avoided in future research by using customized antibodies instead.…”
Section: Nstmentioning
confidence: 99%
“…ICS proved to be a very versatile and reliable method and is now widely used in research for the study of vaccines, antigen response, autoimmune disorders, cancer, etc. (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) The aim of this study was to investigate the variability of interleukin-2 (IL-2), tumor necrosis factor-alpha (TNF-α) and interferon gamma (IFN-γ) synthetic capacity of ex-vivo stimulated CD4+/CD8+ lymphocyte subpopulations in healthy subjects.…”
Section: Introductionmentioning
confidence: 99%
“…Cytokine polarization is a relative definition that reflects the relative ratio of type 1 cytokines over type 2 cytokines [29]. Th1 cytokines are the main mediators in GVHD production.…”
Section: Roc Curvementioning
confidence: 99%
“…Such disparate genotype‐induced immune response profiles, if present within human patient populations, would be expected to have significant effects on both graft survival and responses to immunosuppression and tolerance induction therapies. Human patients with different predetermined IR biases have been described previously in various contexts such as Helicobacter pylori infection [27], T‐cell lymphomas [28], allogeneic stem cell transplantation [29, 30], HIV‐1 infection [31] and asthma [32]. In these clinical conditions, patient groups predisposed toward different IR biases often responded differently to the same therapeutic or prophylactic interventions, requiring treatments to be tailored to individual IR characteristics.…”
Section: Discussionmentioning
confidence: 99%