Th9 Cells as a New Player in Inflammatory Skin Disorders

Jadali, Zohreh

doi:10.18502/ijaai.v18i2.915

Cited by 4 publications

(3 citation statements)

References 74 publications

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“…It is essential to differentiate between the effects of chronic HCV infection and the development of SLE. The fact that the patient's symptoms improved and HCV RNA became negative after treat-ment may have contributed to the unmasking of underlying autoimmune activity [5].…”

Section: Discussionmentioning

confidence: 99%

Hematological and Musculoskeletal Manifestations of Systemic Lupus Erythematosus in A Patient with Chronic Hepatitis C Virus Infection

2023

JPNB

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Systemic lupus erythematosus (SLE) is an autoimmune disease that can present with various clinical manifes- tations, and early diagnosis and treatment are crucial to prevent irreversible organ damage. Here, we report a case of a 35-year-old female with chronic hepatitis C virus (HCV) infection who presented with hematolog- ical and musculoskeletal symptoms, ultimately leading to a diagnosis of SLE. The patient’s workup included positive ANA and dsDNA tests and a CT scan revealing an oval-shaped lytic lesion in the medullary cavity of the right iliac bone.

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Section: Discussionmentioning

confidence: 99%

Hematological and Musculoskeletal Manifestations of Systemic Lupus Erythematosus in A Patient with Chronic Hepatitis C Virus Infection

2023

JPNB

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“…Traditionally, the CD4 + T cell subset lineages have been classified based on the cytokines they produce expression of characteristic transcriptional factors (TFs). Based on this classification, CD4 + T cells have been designated into T-helper-1 (T H 1), T-helper 2 (T H 2), T-helper 17 (T H 17), follicular helper T cells (Tfh), induced T-regulatory cells (iTregs), regulatory type 1 cells (Tr1), and T-helper 9 cells (T H 9) ( 27 – 33 ). In recent years, the diversity of T H subsets has increased in complexity and the designation of T H subsets beyond T H 1, T H 2 and T H 17 cells remains a subject of intense debate as the traditional classification system fails to account for T H cells that are involved in the induction of various pathologies.…”

Section: Cd4 + T Cells In the Skinmentioning

confidence: 99%

T Cell Extracellular Traps: Tipping the Balance Between Skin Health and Disease

et al. 2022

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The role of extracellular traps (ETs) in the innate immune response against pathogens is well established. ETs were first identified in neutrophils and have since been identified in several other immune cells. Although the mechanistic details are not yet fully understood, recent reports have described antigen-specific T cells producing T cell extracellular traps (TETs). Depending on their location within the cutaneous environment, TETs may be beneficial to the host by their ability to limit the spread of pathogens and provide protection against damage to body tissues, and promote early wound healing and degradation of inflammatory mediators, leading to the resolution of inflammatory responses within the skin. However, ETs have also been associated with worse disease outcomes. Here, we consider host-microbe ET interactions by highlighting how cutaneous T cell-derived ETs aid in orchestrating host immune responses against Cutibacterium acnes (C. acnes), a commensal skin bacterium that contributes to skin health, but is also associated with acne vulgaris and surgical infections following joint-replacement procedures. Insights on the role of the skin microbes in regulating T cell ET formation have broad implications not only in novel probiotic design for acne treatment, but also in the treatment for other chronic inflammatory skin disorders and autoimmune diseases.

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“…Th9 cell plays a significant role in causing inflammation in psoriasis, lichen planus and vitiligo diseases and exacerbates the function of other inflammatory cells such as Th1 and Th17 77‐80 . There is also a direct relationship between the number of Th9, the severity of the disease, and the period of inflammation 81,82 . In addition, it has been shown that Th2 cells are able to switch to Th9 under the influence of TGF‐β and IL‐4 83 .…”

Section: Common T Cell Lineages In the Pathogenesis Of Psoriasis Licmentioning

confidence: 99%

The attentive focus on T cell‐mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo

et al. 2020

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T cell‐mediated autoimmune skin diseases develop as a result of the aberrant immune response to the skin cells with T cells playing a central role. These chronic inflammatory skin diseases encompass various types including psoriasis, lichen planus and vitiligo. These diseases show similarities in their immune‐pathophysiology. In the last decade, immunomodulating agents have been very successful in the management of these diseases thanks to a better understanding of the pathophysiology. In this review, we will discuss the immunopathogenic mechanisms and highlight the role of T lymphocytes in psoriasis, lichen planus and vitiligo. This study could provide new insights into a better understanding of targeted therapeutic pathways and biological therapies.

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Th9 Cells as a New Player in Inflammatory Skin Disorders

Cited by 4 publications

References 74 publications

Hematological and Musculoskeletal Manifestations of Systemic Lupus Erythematosus in A Patient with Chronic Hepatitis C Virus Infection

Hematological and Musculoskeletal Manifestations of Systemic Lupus Erythematosus in A Patient with Chronic Hepatitis C Virus Infection

T Cell Extracellular Traps: Tipping the Balance Between Skin Health and Disease

The attentive focus on T cell‐mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo

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