Thalamic Network Oscillations Synchronize Ontogenetic Columns in the Newborn Rat Barrel Cortex

Yang, Jenq‐Wei; An, Shuming; Sun, Jyh-Jang; Reyes‐Puerta, Vicente; Kindler, Jennifer; Berger, Thomas; Kilb, Werner; Luhmann, Heiko J.

doi:10.1093/cercor/bhs103

Cited by 160 publications

(236 citation statements)

References 60 publications

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“…[3][4][5][6][9][10][11][12][13][14][15][16][17][18][19][20] The deflection of a single whisker initially evokes a highly localized sensory response, mapping onto the appropriate barrel column in the primary somatosensory cortex (S1). 3,5,11 However, the sensory response typically spreads over the next milliseconds, invading neighboring cortical barrel columns, depending upon stimulus strength, 3,6 developmental age, 21,22 ongoing spontaneous cortical activity, 4 and ongoing whisker-related behavior. 5,13 In addition, separate secondary hotspots of activity can be observed within tens of milliseconds of whisker deflection, including prominent depolarization of a frontal cortical region, in mouse located ∼1 mm anterior and ∼1 mm lateral to Bregma, the whisker motor cortex (M1).…”

Section: Introductionmentioning

confidence: 99%

Voltage-sensitive dye imaging of mouse neocortex during a whisker detection task

et al. 2016

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Abstract. Sensorimotor processing occurs in a highly distributed manner in the mammalian neocortex. The spatiotemporal dynamics of electrical activity in the dorsal mouse neocortex can be imaged using voltagesensitive dyes (VSDs) with near-millisecond temporal resolution and ∼100-μm spatial resolution. Here, we trained mice to lick a water reward spout after a 1-ms deflection of the C2 whisker, and we imaged cortical dynamics during task execution with VSD RH1691. Responses to whisker deflection were highly dynamic and spatially highly distributed, exhibiting high variability from trial to trial in amplitude and spatiotemporal dynamics. We differentiated trials based on licking and whisking behavior. Hit trials, in which the mouse licked after the whisker stimulus, were accompanied by overall greater depolarization compared to miss trials, with the strongest hit versus miss differences being found in frontal cortex. Prestimulus whisking decreased behavioral performance by increasing the fraction of miss trials, and these miss trials had attenuated cortical sensorimotor responses. Our data suggest that the spatiotemporal dynamics of depolarization in mouse sensorimotor cortex evoked by a single brief whisker deflection are subject to important behavioral modulation during the execution of a simple, learned, goal-directed sensorimotor transformation.

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Section: Introductionmentioning

confidence: 99%

Voltage-sensitive dye imaging of mouse neocortex during a whisker detection task

et al. 2016

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“…Introduction 9 are observed already in the first postnatal week (Engel et al, 2001;Dupont et al, 2006;Yang et al, 2009;Brockmann et al, 2011;Minlebaev et al, 2011;Yang et al, 2012). These oscillations are not only involved in coordinated information processing, but may also contribute to the development of adequate neuronal projections and local circuits (Khazipov and Luhmann, 2006;Hanganu-Opatz, 2010).…”

Section: List Of Figuresmentioning

confidence: 99%

“…Moreover, these oscillations in S1 driven by the spontaneous paws twitches contribute to the formation of the somatotopic sensory cortical map (Khazipov et al, 2004). In the whisker system, gamma and spindle bursts modulate both thalamic-cortico and cortico-thalamic network loops (Minlebaev et al, 2011;Yang et al, 2012). In addition, the precise topographic and functional columnar organization in barrel cortex also needs the localized gamma and spindle bursts in neonatal vibrissal S1 (Yang et al, 2012) induced by the spontaneous whisker movements (Tiriac et al, 2012).…”

Section: Fig 1 Eeg Rhythms In Humansmentioning

confidence: 99%

“…In the whisker system, gamma and spindle bursts modulate both thalamic-cortico and cortico-thalamic network loops (Minlebaev et al, 2011;Yang et al, 2012). In addition, the precise topographic and functional columnar organization in barrel cortex also needs the localized gamma and spindle bursts in neonatal vibrissal S1 (Yang et al, 2012) induced by the spontaneous whisker movements (Tiriac et al, 2012). In the visual system, the patterned spontaneous retinal waves not only contribute to the retinotopic map refinement in the superior colliculus (McLaughlin et al, 2003;Chandrasekaran et al, 2005), but also trigger spindle bursts required for the development of precise maps in V1 (Cang et al, 2005).…”

Section: Fig 1 Eeg Rhythms In Humansmentioning

confidence: 99%

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Resonance properties of different neuronal populations in the immature mouse neocortex

Sun

Luhmann

Kilb

2012

Eur J of Neuroscience

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In vivo recordings in the immature neocortex revealed spontaneous and sensory‐driven oscillatory activity from delta (0.5–4 Hz) to gamma (30–100 Hz) frequencies. In order to investigate whether the resonance properties of distinct neuronal populations in the immature neocortex contribute to these network oscillations, we performed whole‐cell patch‐clamp recordings from visually identified neurons in tangential and coronal neocortical slices from postnatal day (P)0–P7 C57Bl/6 mice. Subthreshold resonance was analysed by sinusoidal current injection of varying frequency. All Cajal–Retzius cells showed subthreshold resonance, with an average frequency of 2.6 ± 0.1 Hz (n = 60), which was massively reduced by ZD7288, a blocker of hyperpolarization‐activated cation currents. Approximately 65.6% (n = 61) of the supragranular pyramidal neurons showed subthreshold resonance, with an average frequency of 1.4 ± 0.1 Hz (n = 40). Application of Ni2+ suppressed subthreshold resonance, suggesting that low‐threshold calcium currents contribute to resonance in these neurons. Approximately 63.6% (n = 77) of the layer V pyramidal neurons showed subthreshold resonance, with an average frequency of 1.4 ± 0.2 Hz (n = 49), which was abolished by ZD7288. Only 44.1% (n = 59) of the subplate neurons showed subthreshold resonance, with an average frequency of 1.3 ± 0.2 Hz (n = 26) and a small resonance strength. In summary, these results demonstrate that neurons in all investigated layers show resonance behavior, with either hyperpolarization‐activated cation or low‐threshold calcium currents contributing to the subthreshold resonance. The observed resonance frequencies are in the range of slow activity patterns observed in the immature neocortex, suggesting that subthreshold resonance may support the generation of this activity.

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“…Moreover, brain rhythms during sleep have themselves been found to be crucial for cortical development, in particular of cortical sensory maps [14] such as in the primary somatosensory cortex (S1) [15,16]. Thus, thalamocortical abnormalities in schizophrenia, which possibly account for sleep-related brain rhythm abnormalities, could also lead to faulty development of cortical sensory areas and thereby contribute to the development of the illness.…”

Section: Department Of Psychiatry University Of New Mexico School Ofmentioning

confidence: 99%

Schizophrenia as a disturbance of cortical sensory maps

Vukadinovic

2012

Translational Neuroscience

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Schizophrenia is a disorder characterized by a variety of symptoms, which among others include hallucinations, delusions and passivity experiences. It has been found that individuals with schizophrenia misattribute their own thoughts and actions to an outside agency (source monitoring deficits), which could account for psychotic experiences such as that of hearing voices. In order to explain the source-monitoring deficits as well as psychosis, it has been proposed that mechanisms that enable anticipation and recognition of sensory consequences of one's own actions are impaired in schizophrenia. Importantly, such mechanisms may require accurate cortical sensory representations such as in the primary somatosensory cortex (S1). The establishment and maintenance of cortical sensory representations has been found to utilize a sleep-related brain rhythm known as spindling. Namely, in the perinatal period in humans and animals, and possibly also thereafter, spontaneous activity in the sensory periphery drives spindle activity in the developing cortical sensory areas, which then contributes to the formation of sensory representations that match bodily features. For example, muscle twitch-spindle sequences during sleep facilitate the formation and maintenance of S1 in accordance with the layout of musculature. This process has been proposed to continue throughout the lifespan and may be particularly important during periods of bodily changes (adolescence, menopause). In schizophrenia, the amount of sleep spindle activity is markedly reduced, which would be expected to result in insufficient cortical sensory representations and have relevance for the relative inability of individuals with schizophrenia to accurately recognize self-initiated actions.

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Thalamic Network Oscillations Synchronize Ontogenetic Columns in the Newborn Rat Barrel Cortex

Cited by 160 publications

References 60 publications

Voltage-sensitive dye imaging of mouse neocortex during a whisker detection task

Voltage-sensitive dye imaging of mouse neocortex during a whisker detection task

Resonance properties of different neuronal populations in the immature mouse neocortex

Schizophrenia as a disturbance of cortical sensory maps

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