Thalamus

Groenewegen, Henk J.

doi:10.1016/b978-012547638-6/50018-3

Cited by 74 publications

(78 citation statements)

References 345 publications

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“…Acceptable lesions were defined as having Ͼ50% damage to the Re area and Ͼ25% damage to the perireuniens (pRe) and Rh, but no more than 10% damage to the adjacent thalamic region. According to Groenewegen and Witter (2004), the main mass of the Re is bordered by the so-called pRe. As for the Re, the pRe has connections with limbic structures, particularly the mPFC (Hoover and Vertes, 2012).…”

Section: Resultsmentioning

confidence: 99%

The Ventral Midline Thalamus (Reuniens and Rhomboid Nuclei) Contributes to the Persistence of Spatial Memory in Rats

Loureiro¹,

Cholvin²,

Lopez³

et al. 2012

Journal of Neuroscience

129

134

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The formation of enduring declarative-like memories engages a dialog between the hippocampus and the prefrontal cortex (PFC). Electrophysiological and neuroanatomical evidence for reciprocal connections with both of these structures makes the reuniens and rhomboid nuclei (ReRh) of the thalamus a major functional link between the PFC and hippocampus. Using immediate early gene imaging (c-Fos), fiber-sparing excitotoxic lesion, and reversible inactivation in rats, we provide evidence demonstrating a contribution of the ReRh to the persistence of a spatial memory. Intact rats trained in a Morris water maze showed increased c-Fos expression (vs home cage and visible platform groups: Ͼ500%) in the ReRh when tested in a probe trial at a 25 d delay, against no change at a 5 d delay; behavioral performance was comparable at both delays. In rats subjected to excitotoxic fiber-sparing NMDA lesions circumscribed to the ReRh, we found normal acquisition of the water-maze task (vs sham-operated controls) and normal probe trial performance at the 5 d delay, but there was no evidence for memory retrieval at the 25 d delay. In rats having learned the water-maze task, lidocaine-induced inactivation of the ReRh right before the probe trial did not alter memory retrieval tested at the 5 d or 25 d delay. Together, these data suggest an implication of the ReRh in the long-term consolidation of a spatial memory at the system level. These nuclei could then be a key structure contributing to the transformation of a new hippocampal-dependent spatial memory into a remote one also depending on cortical networks.

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Section: Resultsmentioning

confidence: 99%

The Ventral Midline Thalamus (Reuniens and Rhomboid Nuclei) Contributes to the Persistence of Spatial Memory in Rats

Loureiro¹,

Cholvin²,

Lopez³

et al. 2012

Journal of Neuroscience

129

134

View full text Add to dashboard Cite

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“…10F ). The AV nucleus forms reciprocal connections with the limbic system and, in particular, with the retrosplenial cortex (Groenewegen and Witter, 2004) as well as the medial prefrontal cortex (Guandalini, 2001), potentially making a link between cortical areas with the earliest and the latest involvement in the slow oscillation. Our results demonstrate that only the first-order nuclei might contribute to the sleep-related gating of peripheral inputs, whereas higher-order thalamic nuclei may facilitate an intracortical dialog during sleep, which is possibly a key component of sleep-dependent memory consolidation (Rasch and Born, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Neurons of the PO nucleus receive ascending inputs from somatosensory, auditory, visual, and vestibular systems (Groenewegen and Witter, 2004), which should not be synchronized with the slow oscillation. The cortical (driver) inputs arrive mainly from somatosensory (S1 and S2) areas, but to a lesser extent from medial frontal cortices (Veinante et al, 2000;Guandalini, 2001); and frontal cortex is the first to display the onset of slow waves, which potentially could drive these neurons and show the early onset of activity in the PO nucleus.…”

Section: Discussionmentioning

confidence: 99%

Global Intracellular Slow-Wave Dynamics of the Thalamocortical System

Sheroziya

Timofeev

2014

Journal of Neuroscience

136

138

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It is widely accepted that corticothalamic neurons recruit the thalamus in slow oscillation, but global slow-wave thalamocortical dynamics have never been experimentally shown. We analyzed intracellular activities of neurons either from different cortical areas or from a variety of specific and nonspecific thalamic nuclei in relation to the phase of global EEG signal in ketamine-xylazine anesthetized mice. We found that, on average, slow-wave active states started off within frontal cortical areas as well as higher-order and intralaminar thalamus (posterior and parafascicular nuclei) simultaneously. Then, the leading edge of active states propagated in the anteroposterior/ lateral direction over the cortex at ϳ40 mm/s. The latest structure we recorded within the slow-wave cycle was the anterior thalamus, which followed active states of the retrosplenial cortex. Active states from different cortical areas tended to terminate simultaneously. Sensory thalamic ventral posterior medial and lateral geniculate nuclei followed cortical active states with major inhibitory and weak tonic-like "modulator" EPSPs. In these nuclei, sharp-rising, large-amplitude EPSPs ("drivers") were not modulated by cortical slow waves, suggesting their origin in ascending pathways. The thalamic active states in other investigated nuclei were composed of depolarization: some revealing "driver"-and "modulator"-like EPSPs, others showing "modulator"-like EPSPs only. We conclude that sensory thalamic nuclei follow the propagating cortical waves, whereas neurons from higher-order thalamic nuclei display "hub dynamics" and thus may contribute to the generation of cortical slow waves.

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“…Thalamostriatal projections are topographically organized (Groenewegen and Witter 2004;Smith et al 2004), and our BDA injections in POm indicate that this thalamic nucleus projects mainly to the DLS. By contrast, the midline and intralaminar nuclei innervate more widespread parts of the striatum (Berendse and Groenewegen 1990;Groenewegen and Witter 2004;Smith et al 2004), many of which receive few if any projections from POm.…”

Section: Discussionmentioning

confidence: 99%

Thalamic POm projections to the dorsolateral striatum of rats: potential pathway for mediating stimulus–response associations for sensorimotor habits

Smith

Mowery

Alloway

2012

Journal of Neurophysiology

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The dorsolateral part of the striatum (DLS) represents the initial stage for processing sensorimotor information in the basal ganglia. Although the DLS receives much of its input from the primary somatosensory (SI) cortex, peripheral somesthetic stimulation activates the DLS at latencies that are shorter than the response latencies recorded in the SI cortex. To identify the subcortical regions that transmit somesthetic information directly to the DLS, we deposited small quantities of retrograde tracers at DLS sites that displayed consistent time-locked responses to controlled whisker stimulation. The neurons that were retrogradely labeled by these injections were located mainly in the sensorimotor cortex and, to a lesser degree, in the amygdala and thalamus. Quantitative analysis of neuronal labeling in the thalamus indicated that the strongest thalamic input to the whisker-sensitive part of the DLS originates from the medial posterior nucleus (POm), a somesthetic-related region that receives inputs from the spinal trigeminal nucleus. Anterograde tracer injections in POm confirmed that this thalamic region projects to the DLS neuropil. In subsequent experiments, simultaneous recordings from POm and the DLS during whisker stimulation showed that POm consistently responds before the DLS. These results suggest that POm could transmit somesthetic information to the DLS, and this modality-specific thalamostriatal pathway may cooperate with the thalamostriatal projections that originate from the intralaminar nuclei.

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Thalamus

Cited by 74 publications

References 345 publications

The Ventral Midline Thalamus (Reuniens and Rhomboid Nuclei) Contributes to the Persistence of Spatial Memory in Rats

The Ventral Midline Thalamus (Reuniens and Rhomboid Nuclei) Contributes to the Persistence of Spatial Memory in Rats

Global Intracellular Slow-Wave Dynamics of the Thalamocortical System

Thalamic POm projections to the dorsolateral striatum of rats: potential pathway for mediating stimulus–response associations for sensorimotor habits

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