Thalassemia minor: a risk factor for osteoporosis?

Greep, Nancy; Anderson, A. L.; Gallagher, J. Christopher

doi:10.1016/0169-6009(92)90822-u

Cited by 18 publications

(8 citation statements)

References 8 publications

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“…Although it has been hypothesized that severe iron deficiency is associated with osteoporosis [11,12], iron overload is well-recognized as a risk factor for osteoporosis [9,13,14,15]. Currently, there is a paucity of research exploring the association of thalassemia [9,15,16] or pernicious anemia [17] with osteoporosis; however, the relationship between IDA, the leading cause of anemia [6,7], and subsequent osteoporosis remains unclear. Although some studies have demonstrated that anemia is associated with osteoporosis [18,19,20], the cause–effect relationship cannot be established [21] due to the limitation of a cross-sectional study design in all of the studies.…”

Section: Introductionmentioning

confidence: 99%

Iron Deficiency Anemia as a Risk Factor for Osteoporosis in Taiwan: A Nationwide Population-Based Study

et al. 2017

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The cause-effect relationship between iron deficiency anemia (IDA) and osteoporosis has not been established in the general population. Thus, the current longitudinal study determined the role of IDA as a risk factor for osteoporosis by analyzing a large nationwide population-based sample. In a sample of 1,000,000 randomly sampled individuals from the 1998–2012. Taiwan National Health Insurance Research Database, patients with IDA (case group (n = 35,751)) and individuals without IDA (control group (n = 178,755)) were compared. Patients who were <20 years of age and who had pre-existing osteoporosis prior to the diagnosis of IDA were excluded. Each patient with IDA was age- and gender-matched to five individuals without IDA. The diagnoses of IDA and osteoporosis (coded using ICD-9CM) were further confirmed with blood test results and X-ray bone densitometry to ensure the accuracy of the diagnoses. Osteoporosis occurred more often among patients with IDA compared to individuals without IDA (2.27% vs. 1.32%, p < 0.001). Cox proportional hazard analysis revealed that the risk for osteoporosis was significantly higher in the case than the control group (hazard ratio (HR) = 1.74; 95% CI = 1.61–1.88) and remained similar after adjustment for covariates (adjusted HR = 1.81; 95% CI = 1.67–1.97). Compared with individuals without IDA, the risk for osteoporosis was even higher for patients with IDA who received intravenous ferrum therapy (adjusted HR = 2.21; 95% CI = 1.85–2.63). In contrast, the risk for osteoporosis was reduced for patients with IDA who received a blood transfusion (adjusted HR = 1.47; 95% CI = 1.20–1.80). As a predictor, prior IDA is a significant and independent risk factor for development of osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Iron Deficiency Anemia as a Risk Factor for Osteoporosis in Taiwan: A Nationwide Population-Based Study

et al. 2017

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“…Recently, however, renal tubular dysfunctions have been detected in adults with β‐ thalassemia minor 5,6 . It has also been reported that the risk for osteoporosis is evident in these patients because of metabolic bone disorders induced by hypercalciuria 7 …”

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confidence: 99%

Renal tubular function in children with β‐thalassemia minor

Kalman¹,

Atay²,

Sakallıoğlu³

et al. 2005

Nephrology

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“…However, thalassemia minor was also described to be a risk factor for osteoporosis resulting in low BMD [8]. …”

Section: Discussionmentioning

confidence: 99%

“…Reduction in bone mineral density (BMD), increased fractures, deformity and chronic bone pain are well known problems in patients with beta thalassemia major [3–6]. To date there are few studies that have investigated BMD and markers of bone metabolism in patients with thalassemia minor [7, 8]. None of the previous trials demonstrated bone structure analysis in these patients.…”

Section: Introductionmentioning

confidence: 99%

Bone microarchitecture deteriorations and a fragility fracture in a patient with beta and alpha heterozygous thalassemia: a case report

Feichtinger¹,

Kocijan²,

Resch³

et al. 2016

Wien Klin Wochenschr

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SummaryTo date there are few studies that have investigated bone mineral density (BMD) and markers of bone metabolism in patients with thalassemia minor form. None of the previous trials presented bone structure analysis in the patient populations. We present the case of a 24-year-old Turkish woman with heterozygous beta and alpha thalassemia who sustained a low-trauma fracture of the inferior pubic ramus. Despite normal markers of bone metabolism, the dual X‑ray absorptiometry (DXA) showed decreased areal bone mineral density. Furthermore, severely reduced bone structure parameters and reduced volumetric bone mineral density was assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT). Due to these diagnostic findings at time of peak bone mass, an osteoanabolic therapy with teriparatide for 24 months was initiated. The findings concerning BMD and bone structure in this patient can be seen as caused by the beta and alpha thalassemia.

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Thalassemia minor: a risk factor for osteoporosis?

Cited by 18 publications

References 8 publications

Iron Deficiency Anemia as a Risk Factor for Osteoporosis in Taiwan: A Nationwide Population-Based Study

Iron Deficiency Anemia as a Risk Factor for Osteoporosis in Taiwan: A Nationwide Population-Based Study

Renal tubular function in children with β‐thalassemia minor

Bone microarchitecture deteriorations and a fragility fracture in a patient with beta and alpha heterozygous thalassemia: a case report

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