Thalassiolins A—C: New Marine‐Derived Inhibitors of HIV cDNA Integrase.

Rowley, David; Hansen, Mark; Rhodes, Denise; Sotriffer, Christoph A.; Ni, Huaiwei; McCammon, J. Andrew; Bushman, Frederic D.; Fenical, William

doi:10.1002/chin.200303213

Cited by 28 publications

(38 citation statements)

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“…However, taking into account the fact that many flavonoids and related compounds such as L-chicoric acid, block viral entry altogether, it is uncertain, at the present, whether the step affected by thalassiolin A during infection in vivo is indeed integration. Regardless of the actual target in vivo, thalassiolin A may nevertheless serve as a starting point for drug development (Rowley et al, 2002).…”

Section: Flavonoidsmentioning

confidence: 99%

Naturally derived anti‐HIV agents

Asres

Seyoum

Veeresham

et al. 2005

Phytotherapy Research

150

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The urgent need for new anti-HIV/AIDS drugs is a global concern. In addition to obvious economical and commercial hurdles, HIV/AIDS patients are faced with multifarious difficulties associated with the currently approved anti-HIV drugs. Adverse effects, the emergence of drug resistance and the narrow spectrum of activity have limited the therapeutic usefulness of the various reverse transcriptase and protease inhibitors that are currently available on the market. This has driven many scientists to look for new anti-retrovirals with better efficacy, safety and affordability. As has always been the case in the search for cures, natural sources offer great promise. Several natural products, mostly of plant origin have been shown to possess promising activities that could assist in the prevention and/or amelioration of the disease. Many of these anti-HIV agents have other medicinal values as well, which afford them further prospective as novel leads for the development of new drugs that can deal with both the virus and the various disorders that characterize HIV/AIDS. The aim of this review is to report new discoveries and updates pertaining to anti-HIV natural products. In the review anti-HIV agents have been classified according to their chemical classes rather than their target in the HIV replicative cycle, which is the most frequently encountered approach. Perusal of the literature revealed that most of these promising naturally derived anti-HIV compounds are flavonoids, coumarins, terpenoids, alkaloids, polyphenols, polysaccharides or proteins. It is our strong conviction that the results and experiences with many of the anti-HIV natural products will inspire and motivate even more researchers to look for new leads from plants and other natural sources.

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Section: Flavonoidsmentioning

confidence: 99%

Naturally derived anti‐HIV agents

Asres

Seyoum

Veeresham

et al. 2005

Phytotherapy Research

150

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“…In a standard plaque reduction assay, Halovir A can equally inhibit the replication of HSV-1 and HSV-2 with an ED 50 value of 280 nm. The mode of action is still not clear, however it Rowley et al (2002) is presumed that halovirs render HSV non-infectious by possible membrane destabilization (Rowley et al, 2003). Stachyflin, a novel terpenoid isolated from the fungus Stachybotrys sp.…”

Section: Fungi-derived Antiviralsmentioning

confidence: 99%

“…1.2.5.2. Thalassiolins A-C. Thalassiolins A-C are sulfated-flavone glycosides, isolated from the Caribbean sea grass Thalassia testudinum (Rowley et al, 2002). Thalassiolin A, the most active compound of this series, inhibits HIV replication in cell culture (IC 50 = 30 M) by targeting integrase-catalyzed strand transfer (IC 50 = 0.4 M).…”

Section: Antivirals Derived From Miscellaneous Marine Organismsmentioning

confidence: 99%

Marine compounds and their antiviral activities

2010

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Available treatments for many infectious diseases are limited. In particular, diseases caused by viral pathogens have demonstrated the need for new medicines, due to the increasing appearance of resistance to these available treatments. Thousands of novel compounds have been isolated from various marine organisms and tested for pharmacological properties, many of which are commercially available. The screening of natural products derived from marine species for antiviral activity has yielded a considerable number of active crude aqueous and organic solvent extracts. Today, over 40 compounds are commercially available in pharmacological markets, including alternative antiviral medicines or those being tested as potential antiviral drugs. Many more are being tested as potential antiviral drugs at the preclinical and clinical stages. The growing interest in marine-derived antiviral compounds, along with the development of new technology in marine cultures and extraction, will significantly expedite the current exploration of the marine environment for compounds with significant pharmacological applications, which will continue to be a promising strategy and new trend for modern medicine.

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“…The large numbers of structurally and pharmacologically significant natural products have been isolated with novel antibiotic, antitumor and anti-inflammatory properties [6,[12][13][14][15][16]. As interests have shifted towards the marine microorganisms, the fungi have begun to be renowned as a potential source for bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

Natural Products with Anticancer Activity from Marine Fungi

Karuppiah

Zhang

2014

Handbook of Anticancer Drugs From Marine Origin

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Cancer is one of the major diseases, which require the improved drugs with fewer side effects. Until now, several marine natural products have been accessed for the anticancer property and few of them are in clinical trials too. Marine fungi are taxonomically diverse, largely productive, biologically active, and chemically unique offering a great scope for discovery of new anticancer drugs. The natural products isolated from the marine fungi are possibly inhibiting the processes such as inflammation, cell differentiation and survival, and metastasis of various signal transduction pathways and their by reducing the risk of cancer. In this chapter, we have discussed about the anticancer, anti-inflammatory and cytotoxic activities of marine derived fungi.

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Thalassiolins A—C: New Marine‐Derived Inhibitors of HIV cDNA Integrase.

Abstract: For Abstract see ChemInform Abstract in Full Text.

Cited by 28 publications

References 1 publication

Naturally derived anti‐HIV agents

Naturally derived anti‐HIV agents

Marine compounds and their antiviral activities

Natural Products with Anticancer Activity from Marine Fungi

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