Thalidomid-Embryopathie bei Kaninchen nach passagerer Lebersch�digung der Muttertiere durch Tetrachlorkohlenstoff

The teratogenic activity of a stable analogue of thalidomide, 2( 2,6-dioxopiperiden-2-yl)-phthalimidine ( EMIz), has been compared in monkeys, rabbits, and rats. After oral administration of 25-250 mg/kg, EMIZ was teratogenic in monkeys and rabbits but only slightly so in rats. After iv injection of the compound dissolved in dimethyl sulfoxide and water, teratogenic effects were observed both in offspring of rabbits and rats receiving doses of 10 mg/kg. The malformations observed in monkeys and rabbits were identical with those observed after thalidomide treatment, but those in rats were not the typical thalidomide-type deformities.

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The teratogenic activity of α thalidomide analogue, EM₁₂, in rabbits, rats, and monkeys

Schumacher

Terapane

Jordan

et al. 1972

Teratology

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Thalidomidembryopathie im Tierversuch

Heine¹

1966

Z. Kinder-Heilk.

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Thalidomidembryopathie im Tierversuch

Heine

Stüwe

1966

Z. Kinder-Heilk.

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Thalidomid-Embryopathie bei Kaninchen nach passagerer Lebersch�digung der Muttertiere durch Tetrachlorkohlenstoff

Cited by 5 publications

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The teratogenic activity of α thalidomide analogue, EM₁₂, in rabbits, rats, and monkeys

The teratogenic activity of α thalidomide analogue, EM₁₂, in rabbits, rats, and monkeys

Thalidomidembryopathie im Tierversuch

Thalidomidembryopathie im Tierversuch

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Thalidomid-Embryopathie bei Kaninchen nach passagerer Lebersch�digung der Muttertiere durch Tetrachlorkohlenstoff

Cited by 5 publications

References 0 publications

The teratogenic activity of α thalidomide analogue, EM12, in rabbits, rats, and monkeys

The teratogenic activity of α thalidomide analogue, EM12, in rabbits, rats, and monkeys

Thalidomidembryopathie im Tierversuch

Thalidomidembryopathie im Tierversuch

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The teratogenic activity of α thalidomide analogue, EM₁₂, in rabbits, rats, and monkeys

The teratogenic activity of α thalidomide analogue, EM₁₂, in rabbits, rats, and monkeys