Thalidomide alleviates acute pancreatitis-associated lung injury via down-regulation of NFκB induced TNF-α

Lv, Ping; Liu, Hongyun; Ji, Shu-Sheng; Wen, Li; Fan, Lijuan

doi:10.1016/j.prp.2014.04.022

Cited by 15 publications

(11 citation statements)

References 38 publications

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“…Of particular note, TNF‐α was expressed more strongly in H5N1 than H9N2 AIV infection in DF‐1 cells regardless of infective dose. This may explain why inhibition of TNF‐α reduces pulmonary recruitment of inflammatory cells and severity of illness associated with H5N1 infection .…”

Section: Discussionmentioning

confidence: 99%

Dynamic analysis of expression of chemokine and cytokine gene responses to H5N1 and H9N2 avian influenza viruses in DF‐1 cells

Luo

Liu

et al. 2018

Microbiology and Immunology

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H5N1 and H9N2 are the most important causes of avian influenza in China. Chemokines and cytokines play important roles in inflammatory response that clearly differ between H5N1 and H9N2 infection. To investigate whether chemokines and cytokines are differentially regulated following H5N1 and H9N2 AIVs infection, dynamic expression of chemokines and cytokines, including IL8L1, IL8L2, CX3CL1, CCL5, CCL20, K203, SCYA4, XLC1, CCLi10, CCL19, IFN-α, IFN-β, IL-1β, IL-6 and TNF-α, were analyzed by real-time quantitative RT-PCR in DF-1 cells. It was found that IL8L1, IL8L2, CX3CL1, CCL5, CCL20, K203, SCYA4, IFN-α, IFN-β, IL-1β, IL-6 and TNF-α increased significantly after induction of H5N1 or H9N2 AIV infection, whereas no expression of XCL1, CCLi10 or CCL19 was detected. H9N2 AIV infection was associated with much stronger chemokine responses than infection with H5N1, whereas the cytokines showed opposite results. It was found that K203 is a constant chemotactic factor independent of subtype of AIVs and infectious dose, CCL20 and IL-1β are constant regardless of the infectious dose but depend on the subtype of AIV, chemotactic factors IL8L1, IL8L2 and CCL5 are dependent both on subtype of AIVs and infectious dose, and K203, CX3CL1, SCYA4, CCL20, IFN-α, IL-1β and TNF-α are specific to responses to H5N1 AIV infection whereas K203, CCL20, IFN-β, IL-1β and IL-6 are specific to H9N2 infection. These results provide basic data for explaining differences in inflammation and phenotypes of histopathological changes caused by H5N1 and H9N2 and add new information on the roles of chemokines and cytokines in virulence of AIVs.

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Section: Discussionmentioning

confidence: 99%

Dynamic analysis of expression of chemokine and cytokine gene responses to H5N1 and H9N2 avian influenza viruses in DF‐1 cells

Luo

Liu

et al. 2018

Microbiology and Immunology

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“…Studies show that, compared with normal cellular genotypes, those lacking the AQP-1 gene or AQP-5 gene were associated with a tenfold decrease in the ability to sense a permeating concentration of water transport and bypass the blood–air barrier. Further, a knockout of both genes produced a 30-fold decrease in water permeability, 21 , 22 which suggests that AQP-1 plays an important role in regulating pulmonary edema. We also show low levels of AQP-1 expression in SAP-induced ALI both at the protein and gene levels.…”

Section: Discussionmentioning

confidence: 96%

The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1

Liang¹,

Zhang²,

Chen³

et al. 2016

DDDT

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Characterized by its acute onset, critical condition, poor prognosis, and high mortality rate, severe acute pancreatitis (SAP) can cause multiple organ failure at its early stage, particularly acute lung injury (ALI). The pathogenesis of ALI is diffuse alveolar damage, including an increase in pulmonary microvascular permeability, a decrease in compliance, and invasion of many inflammatory cells. Corticosteroids are the main treatment method for ALI; however, the associated high toxicity and side effects induce pain in patients. Recent studies show that the effective components in many traditional Chinese medicines can effectively inhibit inflammation with few side effects, which can decrease the complications caused by steroid consumption. Based on these observations, the main objective of the current study is to investigate the effect of alpinetin, which is a flavonoid extracted from Alpinia katsumadai Hayata, on treating lung injury induced by SAP and to explore the mechanism underlying the alpinetin-mediated decrease in the extent of ALI. In this study, we have shown through in vitro experiments that a therapeutic dose of alpinetin can promote human pulmonary microvascular endothelial cell proliferation. We have also shown via in vitro and in vivo experiments that alpinetin upregulates aquaporin-1 and, thereby, inhibits tumor necrosis factor-α expression as well as reduces the degree of lung injury. Overall, our study shows that alpinetin alleviates SAP-induced ALI. The likely molecular mechanism includes upregulated aquaporin expression, which inhibits tumor necrosis factor-α and, thus, alleviates SAP-induced ALI.

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“…Activation of the NF‐κB family of transcription factors, which is mainly regulated by the IκB kinases and the phosphorylation and degradation of IκBα, is of major importance in the orchestration of the inflammatory responses 52‐54 . More relevantly, thalidomide was noted to mitigate acute pancreatitis‐associated lung injury through suppressing TNF‐α induced by NF‐κB 55 . The promoting role of HDAC6 in inflammation and oxidative stress was reported involving the mitogen‐activated protein kinase/NF‐κB signalling pathway 56,57 .…”

Section: Discussionmentioning

confidence: 99%

Thal protects against paraquat‐induced lung injury through a microRNA‐141/HDAC6/IκBα‐NF‐κB axis in rat and cell models

Zheng

Zhu

Zhang

et al. 2020

Basic Clin Pharma Tox

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Paraquat (1,1-dichloro-4,4-bipyridine, PQ) is a widely used herbicide in agriculture and with extremely potent toxicity that leads to serious public health problem once misused. By accidental or voluntary ingestion, PQ poisoning results in numerous deaths annually, mainly in developing countries where PQ is more largely used. 2 In oral ingestion cases, the mortality rate is over 90%. 3 PQ poisoning through oral, skin and respiratory tracts contributes to multiple organ failure including lungs, kidneys, liver and nervous system, in which the lung is the primary target organ. 4,5 This phenomenon was attributed to high affinity of PQ to alveolar cells. 6 Therefore, PQ poisonings usually cause acute lung injury and, ultimately, acute respiratory distress syndrome and death. 7 Unfortunately, despite the large volume of studies in the past

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Thalidomide alleviates acute pancreatitis-associated lung injury via down-regulation of NFκB induced TNF-α

Cited by 15 publications

References 38 publications

Dynamic analysis of expression of chemokine and cytokine gene responses to H5N1 and H9N2 avian influenza viruses in DF‐1 cells

Dynamic analysis of expression of chemokine and cytokine gene responses to H5N1 and H9N2 avian influenza viruses in DF‐1 cells

The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1

Thal protects against paraquat‐induced lung injury through a microRNA‐141/HDAC6/IκBα‐NF‐κB axis in rat and cell models

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