Thalidomide in angiodysplasia‐related bleeding

Abstract

Gastrointestinal haemorrhage from angiodysplastic lesions is not only difficult to identify, but often refractory to endoscopic intervention. Patients often require substantial transfusion support. Thalidomide has emerged as a promising medical strategy in angiodysplasia-related bleeding. We present our experience and report the findings from a review of the literature. Despite its side-effect profile, thalidomide remains the therapeutic modality with the best evidence in this difficult clinical scenario.

Acquired Von Willebrand syndrome and response to desmopressin

“…[3][4][5] The aim of our study was to describe the biochemical and clinical response to DDAVP in patients affected by AVWS. [3][4][5] The aim of our study was to describe the biochemical and clinical response to DDAVP in patients affected by AVWS.…”

“…1,2 When it is practiced correctly and regularly, PA contributes to the development of aerobic capacity, flexibility, strength, coordination and balance, qualities that favour the good health of the musculoskeletal system.1,3,4 According to expert recommendations and the World Health Organization (WHO), adults should perform 10 000 steps a day and accumulate at least 150 minutes of moderate-intensity PA throughout the week 4,5. 1,2 When it is practiced correctly and regularly, PA contributes to the development of aerobic capacity, flexibility, strength, coordination and balance, qualities that favour the good health of the musculoskeletal system.1,3,4 According to expert recommendations and the World Health Organization (WHO), adults should perform 10 000 steps a day and accumulate at least 150 minutes of moderate-intensity PA throughout the week 4,5.…”

“…2 Recently, the successful use of thalidomide and lenalidomide was reported in four patients affected by AVWS and severe bleeding. [3][4][5] The aim of our study was to describe the biochemical and clinical response to DDAVP in patients affected by AVWS.…”

“…Whenit is practiced correctly and regularly, PA contributes to the development of aerobic capacity, flexibility, strength, coordination and balance, qualities that favour the good health of the musculoskeletal system 1,3,4. According to expert recommendations and the World Health Organization (WHO), adults should perform 10 000 steps a day and accumulate at least 150 minutes of moderate-intensity PA throughout the week 4,5.…”

“…Whenit is practiced correctly and regularly, PA contributes to the development of aerobic capacity, flexibility, strength, coordination and balance, qualities that favour the good health of the musculoskeletal system 1,3,4. According to expert recommendations and the World Health Organization (WHO), adults should perform 10 000 steps a day and accumulate at least 150 minutes of moderate-intensity PA throughout the week 4,5. The translation of this practice to patients with haemophilia should be advised with caution, and to reduce the risk of bleeding in these patients, it is necessary to balance the amount and intensity of PA with an adequate adjustment of prophylactic treatment based on pharmacokinetic parameters 2.…”