The 10-item LURN Symptom Index (LURN SI-10) Detects Additional Symptoms and Shows Convergent Validity With the IPSS in Men Presenting With Lower Urinary Tract Symptoms

Glaser, Alexander; Kristof, Tanya W.; Judge, Clark; Javitch, George; Hirsch, Shira; Talaty, Pooja; Helfand, Brian T.; Smith, Abigail R.; Griffith, James W.

doi:10.1016/j.urology.2022.10.019

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…To the best of our knowledge, this is the first study that assesses the validity and reliability of the LURN SI-10 in a non-English language. Recently, the validity of the LURN SI-10 has been tested by comparing with the IPSS and its significant correlation has been reported (14). However, that study included only male patients with LUTS.…”

Section: Discussionmentioning

confidence: 99%

Reliability and validity analysis of Turkish version of the Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-10 (LURN SI-10) questionnaire

Akan,

Tavukcu,

Culpan

et al. 2024

Arch Ital Urol Androl

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Introduction: To evaluate the validity and reliability of the Turkish version of the Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-10 (LURN SI-10). Materials and methods: In this, single-centre study, patients between 18 and 65 years old, who were suffering from lower urinary tract symptoms (LUTS) without any known urinary tract disease and on no medication, were enrolled. The control group consisted of participants, who were admitted to our clinic suffering from any complaint except LUTS and met all of the other inclusion and exclusion criteria. Participants’ demographics such as age, sex, and level of education were recorded. The Turkish version of the LURN SI-10, International Prostate Symptom Score (IPSS) and Overactive Bladder Questionnaire (OAB-V8) were administered to all participants. Construct validity was evaluated by confirmatory factor analysis and concurrent validity was evaluated with correlations to similar measures. Internal consistency (Cronbach's alpha) was used to establish the scale's internal consistency reliability. Results: A total of 164 participants were included in the final analysis. Of those, 57% were male. The individuals were identified as being in the “patient group” (n = 86) and a “control group” (n = 78). The mean age was 48.24 ± 14.30 years. The median total LURN SI-10 scores of patient group and control group were 12.0 (9-18.25) and 4.0 (2.75-6), respectively. The LURN SI-10 questionnaire showed a high correlation with the IPSS and the OAB-V8 questionnaires (r: 0.761; p: 0.001; r: 0.737; p: 0.001, respectively) in concurrent validity analysis. Cronbach’s alpha coefficient of the LURN SI-10 was 0.850. Conclusions: This promising measurement tool can be used to evaluate LUTS in Turkish women and men. Further studies should be conducted to assess the clinical usefulness of this questionnaire.

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Section: Discussionmentioning

confidence: 99%

Reliability and validity analysis of Turkish version of the Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-10 (LURN SI-10) questionnaire

Akan,

Tavukcu,

Culpan

et al. 2024

Arch Ital Urol Androl

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“…First, the AUA-SI omits urinary incontinence and pain, which in the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) cohort, were present in 51% and 17% of treatment-seeking men, respectively, despite exclusion of men with infection or urinary pain as a primary complaint [ 6 , 7 ]. Urgency urinary incontinence, stress urinary incontinence, and post-void dribbling were all associated with higher LURN-SI scores, AUA-SI scores, and bother, and thus mandate assessment [ 7 , 8 ]. Furthermore, a proportion of men present with pain, which can be an important differential diagnostic marker (e.g., between BPH and chronic prostatitis/chronic pelvic pain syndrome).…”

Section: Introductionmentioning

confidence: 99%

“…The LURN Symptom Index SI-29 was designed as a comprehensive tool, whereas the one-page LURN SI-10 can be extracted from the broader LURN SI-29 and was designed for clinical use analogous to the AUA-SI. Both the LURN SI-29 and SI-10 were developed as PROs for patients with LUTS, using both qualitative and quantitative methods, and have shown initial validity evidence in people with LUTS [8,[12][13][14][15]. What is needed now is research on specific conditions, such as rigorous validation of the psychometric properties of these questionnaires in LUTS/BPH.…”

Section: Introductionmentioning

confidence: 99%

Enhanced clinical decisions for management of benign prostatic hyperplasia using patient-reported outcomes: protocol for a prospective observational study

Glaser,

Smith,

Maglaque

et al. 2024

BMC Urol

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Background Lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) significantly impact quality of life among older men. Despite the prevalent use of the American Urological Association Symptom Index (AUA-SI) for BPH, this measure overlooks key symptoms such as pain and incontinence, underscoring the need for more comprehensive patient-reported outcome (PRO) tools. This study aims to integrate enhanced PROs into routine clinical practice to better capture the spectrum of LUTS, thereby improving clinical outcomes and patient care. Methods This prospective observational study will recruit men with LUTS secondary to BPH aged ≥ 50 years from urology clinics. Participants will be stratified into medical and surgical management groups, with PRO assessments scheduled at regular intervals to monitor LUTS and other health outcomes. The study will employ the LURN Symptom Index (SI)-29 alongside the traditional AUA-SI and other non-urologic PROs to evaluate a broad range of symptoms. Data on comorbidities, symptom severity, and treatment efficacy will be collected through a combination of electronic health records and PROs. Analyses will focus on the predictive power of these tools in relation to symptom trajectories and treatment responses. Aims are to: (1) integrate routine clinical tests with PRO assessment to enhance screening, diagnosis, and management of patients with BPH; (2) examine psychometric properties of the LURN SIs, including test-retest reliability and establishment of clinically meaningful differences; and (3) create care-coordination recommendations to facilitate management of persistent symptoms and common comorbidities measured by PROs. Discussion By employing comprehensive PRO measures, this study expects to refine symptom assessment and enhance treatment monitoring, potentially leading to improved personalized care strategies. The integration of these tools into clinical settings could revolutionize the management of LUTS/BPH by providing more nuanced insights into patient experiences and outcomes. The findings could have significant implications for clinical practices, potentially leading to updates in clinical guidelines and better health management strategies for men with LUTS/BPH. Trial registration This study is registered in ClinicalTrials.gov (NCT05898932).

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Efficacy of Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-29 Questionnaire in Assessing Alpha-blocker Treatment Response in Patients With Benign Prostatic Hyperplasia: A Prospective, Multicenter, Cohort Study

Arikan,

Kazan,

Arikan

et al. 2024

Urology

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The 10-item LURN Symptom Index (LURN SI-10) Detects Additional Symptoms and Shows Convergent Validity With the IPSS in Men Presenting With Lower Urinary Tract Symptoms

Cited by 4 publications

References 13 publications

Reliability and validity analysis of Turkish version of the Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-10 (LURN SI-10) questionnaire

Reliability and validity analysis of Turkish version of the Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-10 (LURN SI-10) questionnaire

Enhanced clinical decisions for management of benign prostatic hyperplasia using patient-reported outcomes: protocol for a prospective observational study

Efficacy of Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-29 Questionnaire in Assessing Alpha-blocker Treatment Response in Patients With Benign Prostatic Hyperplasia: A Prospective, Multicenter, Cohort Study

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