The −159C/T polymorphism in the CD14 gene and the risk of asthma: a meta-analysis

Abstract

The -159C/T polymorphism in the CD14 gene has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. The aim of this study is to investigate the association between the -159C/T polymorphism in the CD14 gene and the risk of asthma by meta-analysis. We searched Pubmed, Embase, CNKI database, Wanfang database, Weipu database, and Chinese Biomedical database, covering all publications (last search been performed on April 20, 2010). Statistical analysis was performed by using the softwares Revman 4.2 and STATA 10.0. A total of 17 case-control studies in 17 articles (4,246 cases and 3,631 controls) were included in this meta-analysis. There was no association between this polymorphism and asthma risk in combined analyses (odds ratio (OR) = 0.86 and 95% confidence interval (95% CI) = 0.72-1.02, P = 0.09 for TC + TT vs. CC). In the subgroup analysis by age, ethnicity, and atopic status, no significant associations of asthma risks were obtained from age groups, ethnic groups, and atopic groups for TC + TT vs. CC comparison. For atopic population, significant decreased atopic asthma risks were found among Asian population (OR = 0.69, 95% CI 0.52-0.92, P = 0.01) and children population (OR = 0.69, 95% CI 0.54-0.89, P = 0.0004) for TC + TT vs. CC comparison. This meta-analysis suggests that CD14 is a candidate gene for atopic asthma susceptibility. The -159C/T polymorphism may be a protective factor for atopic asthma in Asian and children. More studies are needed to validate these associations.

Association of CD14 −159 (−260C/T) polymorphism and asthma risk

“…The mixed asthma was an overly broad collection of different phenotypes, which may have unknown underlying confounding factors to not reveal a credible relationship. Interestingly, the pooled results of this study were inconsistent with the results of previous meta-analysis, [24,25] which showed that the TT and TC genotypes were associated with decreased risk of atopic asthma compared with CC in Asian and children. The following reasons may be plausible explanation of the contradictory results: the small sample was included in the 2 meta-analyses, so the results may reveal an unreliable association, also there are 18 case–control studies including 7029 subjects eligible for this meta-analysis among atopic asthma, therefore the result of this meta-analysis may be closer to the real value; there is a lack of golden standard for asthma phenotype definitions, resulting in the misclassification of cases and reduction of statistical power, besides, as we know, several other risk factors, including different environmental exposure, clinical information, and further subtypes, may have an effect on the results and contribute to moderate heterogeneity; and different genotyping methods and various experimental protocols, and different life backgrounds may make these results incredible.…”

“…[21–23] So far, 2 earlier meta-analyses based on different strategies have tried to detect the possible association of CD14 −159C/T polymorphisms with asthma. [24,25] Unfortunately, the former had several noteworthy errors pertaining to study inclusion, data abstraction. [24] The latter had included 3 articles which deviated from Hardy–Weinberg equilibrium (HWE).…”

“…[24,25] Unfortunately, the former had several noteworthy errors pertaining to study inclusion, data abstraction. [24] The latter had included 3 articles which deviated from Hardy–Weinberg equilibrium (HWE). [25] Thereafter, some new studies have been reported about diverse ethnic populations and phenotypes of asthma.…”

Association of CD14 C159T polymorphism with atopic asthma susceptibility in children from Southeastern China: a case-control study

“…Several studies demonstrated that CD14 rs2569190 may be associated with asthma. This association has been analyzed in two metaanalyses (Zhang et al, 2011;Zhao and Bracken, 2011). No significant overall association was found between rs2569190 and asthma.…”

Respiratory health and endotoxin: associations and modification byCD14/-260 genotype

“…There is some evidence that polymorphisms in the CD14 gene are associated with atopic asthma [11], but more importantly, there is emerging evidence that these polymorphisms modify the effect of endotoxin on atopy and atopic disease. This may, to some extent, explain some of the reported inconsistencies in the association of endotoxin with disease.…”