The 2020 Yearbook of Neurorestoratology

Huang, Hongyun; Chen, Lin; Chopp, Michael; Young, Wise; Bach, John R.; He, Xijing; Sarnowaska, Anna; Xue, Mengzhou; Zhao, Rongbao; Shetty, Ashok K.; Siniscalco, Dario; Guo, Xiaoling; Khoshnevisan, Alireza; Hawamdeh, Ziad M.

doi:10.26599/jnr.2021.9040002

Cited by 33 publications

(9 citation statements)

References 84 publications

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“…Despite the availability of over 20 antiepileptic drugs (AEDs) for the symptomatic treatment of epilepsy, approximately one-third of patients with epilepsy have epilepsy refractory to AEDs [2]. It is generally acknowledged that epilepsy surgery and neuromodulation surgery are effective therapies to treat refractory epilepsy [3,4]. Recent studies have shown that neurostimulation has also become one of the effective therapies for refractory epilepsy [5,6].…”

Section: Introductionmentioning

confidence: 99%

Study on the relationship between obesity and complications of Pediatric Epilepsy surgery

et al. 2023

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Objective Studies have shown that obesity has a significant impact on poor surgical outcomes. However, the relationship between obesity and pediatric epilepsy surgery has not been reported. This study aimed to explore the relationship between obesity and complications of pediatric epilepsy surgery and the effect of obesity on the outcome of pediatric epilepsy surgery, and to provide a reference for weight management of children with epilepsy. Methods A single-center retrospective analysis of complications in children undergoing epilepsy surgery was conducted. Body mass index (BMI) percentiles were adjusted by age and used as a criterion for assessing obesity in children. According to the adjusted BMI value, the children were divided into the obese group (n = 16) and nonobese group (n = 20). The intraoperative blood loss, operation time, and postoperative fever were compared between the two groups. Results A total of 36 children were included in the study, including 20 girls and 16 boys. The mean age of the children was 8.0 years old, ranging from 0.8 to 16.9 years old. The mean BMI was 18.1 kg/m2, ranging from 12.4 kg/m2 to 28.3 kg/m2. Sixteen of them were overweight or obese (44.4%). Obesity was associated with higher intraoperative blood loss in children with epilepsy (p = 0.04), and there was no correlation between obesity and operation time (p = 0.21). Obese children had a greater risk of postoperative fever (56.3%) than nonobese children (55.0%), but this was statistically nonsignificant (p = 0.61). The long-term follow-up outcomes showed that 23 patients (63.9%) were seizure-free (Engel grade I), 6 patients (16.7%) had Engel grade II, and 7 patients (19.4%) had Engel grade III. There was no difference in long-term seizure control outcomes between obese and nonobese groups (p = 0.682). There were no permanent neurological complications after surgery. Conclusion Compared with nonobese children with epilepsy, obese children with epilepsy had a higher intraoperative blood loss. It is necessary to conduct early weight management of children with epilepsy as long as possible.

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Section: Introductionmentioning

confidence: 99%

Study on the relationship between obesity and complications of Pediatric Epilepsy surgery

et al. 2023

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“…Surgery for pelvic fractures is complicated, and open reduction and internal fixation of the pelvis is the current standard for the treatment of acetabular fractures [ 3 ]. In addition to the surgical challenge of treating acetabular fractures in the elderly or even trying to restore degenerative changes [ 4 ], the condition of such patients is often accompanied by cardiovascular and cerebrovascular diseases, abnormal glucose metabolism, and compensatory liver and kidney function, which will lead to reduced tolerance for surgery [ 5 ]. Therefore, there is the potential for many postoperative complications and other factors of uncertainty, often leading to the unsatisfactory results.…”

Section: Introductionmentioning

confidence: 99%

Finite element analysis of the Union Plate in treating elderly acetabular fracture patients

et al. 2022

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Background Elderly acetabular fractures are one of the more difficult types of fractures to resolve. For patients at this age, the more common type of fracture is comminuted. How to better fix this type of fracture has always been an issue of concern. This study was performed to observe the mechanical properties of different internal fixation methods used in treating elderly acetabular fracture patients. Methods A model of a comminuted acetabular fracture in osteoporosis was established, consisting of an anterior column–posterior hemitransverse fracture with disruption of the quadrilateral surface. Fixation of the acetabular fracture model using a reconstruction plate and Union Plates was simulated. For the different internal fixation methods, static and transient modal analyses were performed under different loads, with an action time of 0.21 s and an analysis time of 0.7 s. The stress of the model was observed in the static analysis, and the displacement of the nodes and the entire model in the U1 direction was observed in the transient modal analysis. Results In the static analysis, the stress of the osteoporosis model, the suprapectineal pelvic reconstruction plate model, the infrapectineal quadrilateral surface buttress plate model, and the suprapectineal quadrilateral surface buttress plate model were 42.62 MPa, 37.49 MPa, 44.39 MPa, and 46.15 MPa, respectively. The stress was mainly distributed near the suprapubic branch. The corresponding displacement in the U1 direction was 0.1500 mm, 0.1020 mm, 0.0836 mm, and 0.0990 mm, respectively. In the transient modal analysis, there was a significant difference in displacement between the different models (P < 0.05). When different loads were applied with the same fixation method, there was no significant difference in model displacement (P > 0.05). Conclusion Static and transient modal analyses show that the infrapectineal quadrilateral surface buttress plate or the suprapectineal quadrilateral surface buttress plate has an advantage in maintaining the stability of fracture fragments when fixing comminuted acetabular fractures in elderly individuals. The infrapectineal quadrilateral surface buttress plate also presents better biomechanical results.

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“…According to vari-ous hospital-based studies [4][5][6], the prevalence of PSCID varies from 11.6% to 56.3%. Therefore, neurorestoration of cognitive impairment has gained increasing interest among researchers [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Matrix metalloproteinase-9 (MMP-9) is a member of the MMP family with 26 extracellular and intracellular matrix-degrading enzymes that regulate many zinc-binding proteolytic enzymes physiological processes, including activation of growth factors, tumor growth and metastasis, cleavage of zymogens, and remodeling of the extracellular matrix [7,8]. MMP-9 is mainly produced by neurons, and its expression and activity have been detected in adult brain structure, such as the hippocampus, cortex, striatum, and cerebellum [9,10]. In neurons, the MMP-9 expression is induced by neuronal activity under both physiological and pathological conditions, such as stroke [11,12] and epilepsy [13].…”

Section: Introductionmentioning

confidence: 99%

Is Matrix Metalloproteinase-9 Associated with Post-Stroke Cognitive Impairment or Dementia?

Zhao¹,

Yang²,

Xue³

et al. 2022

J. Integr. Neurosci.

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Background: Matrix metalloproteinase-9 (MMP-9) is a significant protease required for synaptic plasticity, learning, and memory. Yet, the role of MMP-9 in the occurrence and development of cognitive decline after ischemic stroke is not fully understood. In this study, we used clinical data experiments to further investigate whether MMP-9 and genetic polymorphism are associated with poststroke cognitive impairment or dementia (PSCID). Materials and Methods: A total of 148 patients with PSCID confirmed by the Montreal Cognitive Assessment (MoCA) 3 months after onset (PSCID group) were included in the study. The MMP-9 rs3918242 polymorphisms were analyzed using polymerase chain reaction coupled with restriction fragment length polymorphism, and the serum level of MMP-9 was measured using enzyme-linked immunosorbent assay (ELISA). The same manipulations have been done on 169 ischemic stroke patients without cognitive impairment (NCI group) and 150 normal controls (NC group). Results: The expression level of serum MMP-9 in the PSCID group and NCI group was higher compared to the NC group, and the levels in the PSCID group were higher than that in the NCI group (all p < 0.05). Diabetes mellitus, hyperhomocysteinemia, and increased serum MMP-9 levels were the main risk factors of cognitive impairment after ischemic stroke. The serum level of MMP-9 was negatively correlated with the MoCA score, including visual-spatial executive, naming, attention, language, and delayed recall. Genetic polymorphism showed that TC genotype with MMP-9 rs3918242 and CC genotype were associated with a significantly increased risk of PSCID; moreover, the TC genotype significantly increased the risk of cognitive impairment. In the TCCC genotype of MMP-9 rs3918242, diabetes mellitus and hyperhomocysteinemia were associated with the increased risk of PSCID; also, hyperhomocysteinemia could increase the risk of cognitive impairment. Conclusions: MMP-9 level and MMP-9 rs3918242 polymorphism have an important role in the occurrence and development of post-stroke cognitive impairment or dementia (PSCID).

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The 2020 Yearbook of Neurorestoratology

Cited by 33 publications

References 84 publications

Study on the relationship between obesity and complications of Pediatric Epilepsy surgery

Study on the relationship between obesity and complications of Pediatric Epilepsy surgery

Finite element analysis of the Union Plate in treating elderly acetabular fracture patients

Is Matrix Metalloproteinase-9 Associated with Post-Stroke Cognitive Impairment or Dementia?

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