The 41^st Manfred Donike workshop on doping analysis

Investigation of the pharmacological effects and analytical methods of Meclofenoxate and its metabolites

“…Meclofenoxate is rapidly degraded to 4-chlorophenoxyacetic acid (4-CPA) in biological fluids (e.g. human plasma or urine) [6], but the presence of 4-CPA in urine may result not only from the use of meclofenoxate but also from the following permitted dosing: (1) foods containing 4-CPA residues, which are also used as herbicides and plant growth regulators in some countries or regions of the world [7][8][9] ; (2) chlorphenesin [3-(p-chlorophenoxy)-propane-1,2-diol], a non-prohibited substance used as a preservative in cosmetics and lotions [10]or approved for use in specific countries, such as chlorfenvinyl carbamate, a centrally acting skeletal muscle relaxant used to relieve muscle pain that can be converted to 4-CPA in vivo and therefore also represents a potential source of target analytes to be considered in anti-doping testing procedures to be considered in antidoping testing procedures [11].…”