The 5 Hallmarks of Biomaterials Success: An Emphasis on Orthopaedics

Williams, Dustin L.; Isaacson, Brad M.

doi:10.4236/abb.2014.54035

Cited by 12 publications

(5 citation statements)

References 89 publications

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“…Surgical implantation of metals and ceramics has been used to restore function for individuals with diseased and compromised tissue for the past 200 years. 1 However, the success of direct skeletal attachment with metal substrates remained limited until Per-Ingvar Brånemark discovered the integration potential between titanium and bone. 2 Brånemark and his coworkers coined the term "osseointegration" (OI) to describe the ability of titanium to form a mechanical and functional interconnection with osseous tissue without the formation of interpositioned connective tissue.…”

Section: Introduction To Osseointegrationmentioning

confidence: 99%

Osseointegration: a review of the fundamentals for assuring cementless skeletal fixation

Isaacson

Jeyapalina²

2014

ORR

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Direct skeletal fixation, termed osseointegration, has expanded in the last century and includes use in total joint replacements, the edentulous mandible and maxilla, and percutaneous osseointegrated prosthetics. Although it is well known that titanium and bone have the ability to form a durable bone-implant interface, new applications have emerged in the field of orthopedics, which requires a more thorough assessment of the literature. This review aims to introduce the basic biological principles for attaining osseointegration and discusses the major factors for assuring successful cementless fixation.

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Section: Introduction To Osseointegrationmentioning

confidence: 99%

Osseointegration: a review of the fundamentals for assuring cementless skeletal fixation

Isaacson

Jeyapalina²

2014

ORR

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“…[1,2] The implantation of biomaterials DOI: 10.1002/mabi.202200115 into the bone tissue is a common technique for joining fractured bones or substituting for the function of bones. [3,4] Conventionally, these implants are made of metal, [5] including stainless steel, cobaltchrome, and titanium-based alloys, which have high mechanical strength and resistance to fatigue. [6] However, despite their routine use in clinical practice, the use of metallic implants still faces certain challenges.…”

Section: Introductionmentioning

confidence: 99%

Phototethering of Collagen onto Polyetheretherketone Surfaces to Enhance Osteoblastic and Endothelial Performance

Arisaka

Masuda

Yoda

et al. 2022

Macromolecular Bioscience

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Polyetheretherketone (PEEK) is a candidate material for bone implants as an alternative to metals. However, PEEK exhibits poor osseointegration and low endothelial compatibility. This study demonstrates the phototethering of collagen onto PEEK surfaces to facilitate osteoblastic and vascular endothelial performance. In particular, collagen with methacryloyl groups is covalently tethered to the PEEK surface via surface-initiated photopolymerization. This process is simpler than the conventional method of collagen-tethering and can be extended to the surface-patterning treatment of collagen. The collagen is confirmed to be tethered to the PEEK surface using attenuated total reflection Fourier transform infrared measurements, bicinchoninic acid assays, and atomic force microscopic observations. When human bone marrow-derived mesenchymal stem cells (HbmMSCs) are cultured on collagen-tethered PEEK (COL-PEEK) surfaces, the cells favorably adhere and proliferate. After inducing osteogenic differentiation, the cells on the COL-PEEK surfaces show higher expression levels of osteoblast-related genes and mineralization than those on the PEEK surface. Moreover, the tethering of collagen greatly improves endothelial proliferation. The COL-PEEK surfaces promotes endothelial networking in coculture with HbmMSCs. These results suggest that COL-PEEK is highly compatible with both osteoblasts and vascular endothelial cells. COL-PEEK is a promising implant that induces osteogenesis and angiogenesis to repair bone tissues.

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“…Surgical implants made of metal or ceramics were applied for centuries to replace dead tissue [1] . However there is limited success in achieving bony integration with implants [2] .…”

Section: Introductionmentioning

confidence: 99%

Osseointegration in uncemented total hip arthroplasty: A study of 37 cases

Sen¹,

Morshed²,

Rahman³

et al. 2021

Int. J. Orthop. Sci.

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Introduction: Osseointegration is the ability of implants to establish mechanical and functional bond with bone without forming any connective tissue. Osseointegration is useful for clinical follow-up in many implants e.g. dental implants, hearing aids, spinal fusion implants, prosthesis. Endoprosthesis functions pain free when their anchoring components are firmly fixed to the osseous tissue. Total hip arthroplasty is a common procedure in many conditions that reduces pain and improves functions. Noncemented implants need precise preparation of implant bed and additional fixation device such as screws or projections that cut into the bone to achieve stability. The long term stability and function of joint replacement can be evaluated on the basis of outcomes. If improper osseointegration occurs then fibrinous tissue formed between bone and implant that cause weak and loose implant. Materials and Methods: This was an observational type of study where non-cemented total hip replacement done by different surgeons were included for follow-up. The follow-ups were done in US

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The 5 Hallmarks of Biomaterials Success: An Emphasis on Orthopaedics

Cited by 12 publications

References 89 publications

Osseointegration: a review of the fundamentals for assuring cementless skeletal fixation

Osseointegration: a review of the fundamentals for assuring cementless skeletal fixation

Phototethering of Collagen onto Polyetheretherketone Surfaces to Enhance Osteoblastic and Endothelial Performance

Osseointegration in uncemented total hip arthroplasty: A study of 37 cases

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