The aac(6')Ib gene in Proteus mirabilis strains resistant to aminoglycosides.

Abstract

Abstract:The aim of this study was to evaluate the presence of aac(6')-Ib gene conferring resistance to aminoglycosides in Proteus mirabilis strains. Five isolates had aac(6')-Ib gene. In one case the gene was no-expressed. Three isolates were resistant to all aminoglycosides and minimum inhibitory concentrations were ≥ 256 μg/ml. Additionally, all positive strains were resistant to tetracycline and ciprofloxacin.

Prevalence and sequence of aminoglycosides modifying enzymes genes among E.coli and Klebsiella species isolated from Egyptian hospitals

“…In another study on P. mirabilis and P. aeruginosa isolates from Poland,the aac(6′)-Ib gene was detected in 71.43% and 58.3% of strain, respectively (Sacha et al, 2012;Wleczorek, Sacha, & Hauschild, 2008). However,in Iran high rate(71.0%) of AME among CTX-M-15 producing K. pnumonia (Peerayeh, Rostoni, Siadat, & Derakhshan, 2014).…”

Occurrence of the <i>aacA4</i> gene among multidrug resistant strains of <i>Pseudomonas aeruginosa</i> isolated from bronchial secretions obtained from the Intensive Therapy Unit at University Hospital in Bialystok, Poland

“…Because these aminoglycoside resistance genes are usually located on mobile genetic elements like plasmid, transposon, or integrons [8], there is growing concern that they could easily spread and be disseminated among other bacteria such as Staphylococcus aureus [9] or Enterobacteriacae [10,11].…”

Dissemination of Genes Encoding Aminoglycoside-Modifying Enzymes andarmAAmongEnterobacteriaceaeIsolates in Northwest Iran

“…The AAC(6¢)-Ib is the most prevalent among AAC(6¢) enzymes. 15,17,18 In countries, where amikacin usage is very high, the incidence of AAC(6¢)-I as a single or combination aminoglycoside resistance mechanism is high. The prevalence of aac(6¢)-Ib was significantly higher (31.6%) than previous reports from Spain 12 and China 3 that detected 4.2% and 19.6%, respectively.…”