The ability of HDL to inhibit VCAM-1 expression and oxidized LDL uptake is impaired in renal patients

Jurek, Aleksandra; B, Turyna; Kubit, Piotr; Klein, Andrzej

doi:10.1016/j.clinbiochem.2008.04.019

Cited by 20 publications

(15 citation statements)

References 13 publications

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“…The molecular structure of HDL is not static, but rather fluid: apolipoproteins can dissociate from HDL particles to interact with cellular structures and subsequently associate with HDL again ( Vedhachalam et al, 2010 ). Recent studies have focused on the loss of antioxidative and antiinflammatory activities of HDL in uremic patients ( Jurek et al, 2008 ;Vaziri et al, 2009 ). There is decreased activity of anti-inflammatory and antioxidative factors in uremic patients.…”

Section: The Imbalance Between Atheroprotective and Proatherogenic Momentioning

confidence: 97%

The role of serum amyloid A and sphingosine-1-phosphate on high-density lipoprotein functionality

Prüfer¹,

Kleuser

Giet³

2014

Biological Chemistry

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The high-density lipoprotein (HDL) is one of the most important endogenous cardiovascular protective markers. HDL is an attractive target in the search for new pharmaceutical therapies and in the prevention of cardiovascular events. Some of HDL's anti-atherogenic properties are related to the signaling molecule sphingosine-1-phosphate (S1P), which plays an important role in vascular homeostasis. However, for different patient populations it seems more complicated. Significant changes in HDL's protective potency are reduced under pathologic conditions and HDL might even serve as a proatherogenic particle. Under uremic conditions especially there is a change in the compounds associated with HDL. S1P is reduced and acute phase proteins such as serum amyloid A (SAA) are found to be elevated in HDL. The conversion of HDL in inflammation changes the functional properties of HDL. High amounts of SAA are associated with the occurrence of cardiovascular diseases such as atherosclerosis. SAA has potent pro-atherogenic properties, which may have impact on HDL's biological functions, including cholesterol efflux capacity, antioxidative and anti-inflammatory activities. This review focuses on two molecules that affect the functionality of HDL. The balance between functional and dysfunctional HDL is disturbed after the loss of the protective sphingolipid molecule S1P and the accumulation of the acute-phase protein SAA. This review also summarizes the biological activities of lipid-free and lipid-bound SAA and its impact on HDL function.

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Section: The Imbalance Between Atheroprotective and Proatherogenic Momentioning

confidence: 97%

The role of serum amyloid A and sphingosine-1-phosphate on high-density lipoprotein functionality

Prüfer¹,

Kleuser

Giet³

2014

Biological Chemistry

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“…This study showed that a decreased ability of HDL to suppress expression of adhesion molecules in endothelial cells was a potential risk factor for atherosclerosis development. This could be due to oxidative modification of HDL and the significantly reduced serum PON1 activity in these patients (21). In vitro studies have demonstrated that purified PON1 had an anti-inflammatory effect in the presence of HDL, causing a 3-fold reduction in ICAM-1 levels.…”

mentioning

confidence: 98%

Impairment of High-Density Lipoprotein Resistance to Lipid Peroxidation and Adipose Tissue Inflammation in Obesity Complicated by Obstructive Sleep Apnea

Yadav

Aghamohammadzadeh

Liu

et al. 2014

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…[9][10][11][12][13][14][15][16][17] The composition of uremic HDL was found to shift toward a proinflammatory phenotype, which was observed to negatively affect cholesterol efflux properties, cytokine production, and adhesion molecule expression on monocytes and endothelial cells. 7,9,10,18 Those observations led to the conclusion that specific uremia-induced compositional changes in the lipid and protein moiety render HDL dysfunctional or even proinflammatory. Here, we investigated alterations in HDL composition and metrics of HDL functionality in patients undergoing HD or PD.…”

mentioning

confidence: 99%

Dialysis Modalities and HDL Composition and Function

Holzer¹,

Schilcher²,

Curcic³

et al. 2015

Journal of the American Society of Nephrology

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Lipid abnormalities may have an effect on clinical outcomes of patients on dialysis. Recent studies have indicated that HDL dysfunction is a hallmark of ESRD. In this study, we compared HDL composition and metrics of HDL functionality in patients undergoing hemodialysis (HD) or peritoneal dialysis (PD) with those in healthy controls. We detected a marked suppression of several metrics of HDL functionality in patients on HD or PD. Compositional analysis revealed that HDL from both dialysis groups shifted toward a more proinflammatory phenotype with profound alterations in the lipid moiety and protein composition. With regard to function, cholesterol efflux and anti-inflammatory and antiapoptotic functions seemed to be more severely suppressed in patients on HD, whereas HDL-associated paraoxonase activity was lowest in patients on PD. Quantification of enzyme activities involved in HDL metabolism suggested that HDL particle maturation and remodeling are altered in patients on HD or PD. In summary, our study provides mechanistic insights into the formation of dysfunctional HDL in patients with ESRD who are on HD or PD.

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The ability of HDL to inhibit VCAM-1 expression and oxidized LDL uptake is impaired in renal patients

Cited by 20 publications

References 13 publications

The role of serum amyloid A and sphingosine-1-phosphate on high-density lipoprotein functionality

The role of serum amyloid A and sphingosine-1-phosphate on high-density lipoprotein functionality

Impairment of High-Density Lipoprotein Resistance to Lipid Peroxidation and Adipose Tissue Inflammation in Obesity Complicated by Obstructive Sleep Apnea

Dialysis Modalities and HDL Composition and Function

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