The ability of natural ketones to interact with bacterial quorum sensing systems

Plyuta, V. A.; Popova, Alexandra A.; Кокшарова, О. А.; Kuznetsov, Alexander; Khmel, I. A.

doi:10.3103/s0891416814040077

Cited by 9 publications

(7 citation statements)

References 18 publications

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“…), and affect bacterial Quorum sensing systems (Plyuta et al. ) and bacteria biofilms (Plyuta et al. ).…”

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confidence: 99%

“…Bacteria can use VOCs to interact with other organisms: bacteria, fungi, plants (Effmert et al 2012, Weise et al 2012, Bos et al 2013, Farag et al 2013, Audrain et al 2015, Giorgio et al 2015. For example, bacterial VOCs differently influence plant growth and productivity (Bailly andWeisskopf 2012, Kanchiswamy et al 2015), suppress the development of different invertebrates, fungi and bacteria (Popova et al 2014), and affect bacterial Quorum sensing systems (Plyuta et al 2014) and bacteria biofilms (Plyuta et al 2016). VOCs can act as signaling molecules to synchronize certain actions such as sporulation mediated by geosmin (Sch€ oller et al 2002) within an organism or a population, or to impact other organisms living in the environment (Stahl andParkin 1976, Bruce et al 2005).…”

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confidence: 99%

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Inhibition of cyanobacterial photosynthetic activity by natural ketones

Voronova

Konyukhov

Кокшарова

et al. 2019

Journal of Phycology

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Microbial volatiles have a significant impact on the physiological functions of prokaryotic and eukaryotic organisms. Various ketones are present in volatile mixtures produced by plants, bacteria, and fungi. Our earlier results demonstrated the inhibitory effects of soil bacteria volatiles, including ketones, on cyanobacteria. In this work, we thoroughly examined the natural ketones, 2‐nonanone and 2‐undecanone to determine their influence on the photosynthetic activity in Synechococcus sp. PCC 7942. We observed for the first time that the ketones strongly inhibit electron transport through PSII in cyanobacteria cells in vivo. The addition of ketones decreases the quantum yield of primary PSII photoreactions and changes the PSII chlorophyll fluorescence induction curves. There are clear indications that the ketones inhibit electron transfer from QA to QB, electron transport at the donor side of PSII. The ketones can also modify the process of energy transfer from the antenna complex to the PSII reaction center and, by this means, increase both chlorophyll fluorescence quantum yield and the chlorophyll excited state lifetime. At the highest tested concentration (5 mM) 2‐nonanone also induced chlorophyll release from Synechococcus cells that strongly indicates the possible role of the ketones as detergents.

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“…), and affect bacterial Quorum sensing systems (Plyuta et al. ) and bacteria biofilms (Plyuta et al. ).…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Inhibition of cyanobacterial photosynthetic activity by natural ketones

Voronova

Konyukhov

Кокшарова

et al. 2019

Journal of Phycology

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“…chlororaphis [71]. Linear ketones (2-heptanone, 2-nonanone, 2-undecanone) and 2-aminoacetophenone showed an activity on engineered AHL biosensors [72,73].…”

Section: Disruption Of Quorum Sensingmentioning

confidence: 99%

Bacterial volatile compound-based tools for crop management and quality

Cellini

Spinelli

Donati

et al. 2021

Trends in Plant Science

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“…It was demonstrated that ketones bind with protein (bovine serum albumin) [12]. Moreover, 2-nonanone and 2-undecanone demonstrated an inhibitory action on protein refolding in bacteria [13], which can suppress the expression of genes involved in Quorum Sensing regulation in bacterial cells [14] and negatively affected biofilm formation by Agrobacterium tumefaciens [15].…”

Section: Introductionmentioning

confidence: 99%

Four New Genes of Cyanobacterium Synechococcus elongatus PCC 7942 Are Responsible for Sensitivity to 2-Nonanone

et al. 2020

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Microbial volatile organic compounds (VOCs) are cell metabolites that affect many physiological functions of prokaryotic and eukaryotic organisms. Earlier we have demonstrated the inhibitory effects of soil bacteria volatiles, including ketones, on cyanobacteria. Cyanobacteria are very sensitive to ketone action. To investigate the possible molecular mechanisms of the ketone 2-nonanone influence on cyanobacterium Synechococcus elongatus PCC 7942, we applied a genetic approach. After Tn5-692 transposon mutagenesis, several 2-nonanone resistant mutants have been selected. Four different mutant strains were used for identification of the impaired genes (Synpcc7942_1362, Synpcc7942_0351, Synpcc7942_0732, Synpcc7942_0726) that encode correspondingly: 1) a murein-peptide ligase Mpl that is involved in the biogenesis of cyanobacteria cell wall; 2) a putative ABC transport system substrate-binding proteins MlaD, which participates in ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane by aberrantly localized phospholipids transport from outer to inner membranes of bacterial cells; 3) a conserved hypothetical protein that is encoding by gene belonging to phage gene cluster in Synechococcus elongatus PCC 7942 genome; 4) a protein containing the VRR-NUC (virus-type replication-repair nuclease) domain present in restriction-modification enzymes involved in replication and DNA repair. The obtained results demonstrated that 2-nonanone may have different targets in Synechococcus elongatus PCC 7942 cells. Among them are proteins involved in the biogenesis and functioning of the cyanobacteria cell wall (Synpcc7942_1362, Synpcc7942_0351, Synpcc7942_0732) and protein participating in stress response at DNA restriction-modification level (Synpcc7942_0726). This paper is the first report about the genes that encode protein products, which can be affected by 2-nonanone.

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The ability of natural ketones to interact with bacterial quorum sensing systems

Cited by 9 publications

References 18 publications

Inhibition of cyanobacterial photosynthetic activity by natural ketones

Inhibition of cyanobacterial photosynthetic activity by natural ketones

Bacterial volatile compound-based tools for crop management and quality

Four New Genes of Cyanobacterium Synechococcus elongatus PCC 7942 Are Responsible for Sensitivity to 2-Nonanone

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