1997
DOI: 10.1038/sj.cdd.4400246
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The ability to cleave 28S ribosomal RNA during apoptosis is a cell-type dependent trait unrelated to DNA fragmentation

Abstract: Discrete cleavages within 28S rRNA divergent domains have previously been found to coincide with DNA fragmentation during apoptosis. Here we show that rRNA and DNA cleavages can occur independently in apoptotic cells, i.e. that the previously observed correlation is likely to be coincidental. In HL-60 cells, apoptosis with massive DNA fragmentation could be induced without any signs of rRNA cleavage. The opposite situation; rRNA cleavage without concomitant internucleosomal DNA fragmentation, was found in okad… Show more

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Cited by 26 publications
(25 citation statements)
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“…Houge and co-workers observed no specific cleavage of 18S rRNA during apoptosis. 59,61,62 However, recent reports revealed that both the 28S rRNA and the 18S rRNA are cleaved in several cell lines during apoptosis. 63 Interestingly, it has also been reported that the mitochondrial 16S rRNA molecule can be cleaved after apoptotic stimulation.…”
Section: The 28s Rrna Molecule Is Cleaved During Apoptosismentioning
confidence: 99%
See 4 more Smart Citations
“…Houge and co-workers observed no specific cleavage of 18S rRNA during apoptosis. 59,61,62 However, recent reports revealed that both the 28S rRNA and the 18S rRNA are cleaved in several cell lines during apoptosis. 63 Interestingly, it has also been reported that the mitochondrial 16S rRNA molecule can be cleaved after apoptotic stimulation.…”
Section: The 28s Rrna Molecule Is Cleaved During Apoptosismentioning
confidence: 99%
“…62 The 28S rRNA molecule is also cleaved in the apoptotic human leukemia cell lines K562, Molt-3, Molt-4 and U937. 62 However, in the human HL-60 leukemia cells apoptosis could be induced without any signs of rRNA cleavage. Houge and co-workers observed no specific cleavage of 18S rRNA during apoptosis.…”
Section: The 28s Rrna Molecule Is Cleaved During Apoptosismentioning
confidence: 99%
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