The AbioCor implantable replacement heart

Dowling, Robert D.; Gray, Laman A.; Etoch, Steven W.; Laks, Hillel; Marelli, Daniel; Samuels, Louis E.; Entwistle, John W.; Couper, G.S.; Vlahakes, Gus J.; Frazier, O.H.

doi:10.1016/s0003-4975(03)00484-3

Cited by 86 publications

(36 citation statements)

References 14 publications

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“…The conducting heart surgeon may then be assisted in planning the placement of the system components before the implantation procedure is initiated. A similar approach has been investigated by Dowling et al for implanting the Abiocor TAH [17-19]. These authors reveal virtual implantation planning as, “a powerful tool that we have become reliant on for selection of patients“ from [19].…”

Section: Resultsmentioning

confidence: 98%

Image based evaluation of mediastinal constraints for the development of a pulsatile total artificial heart

Fritschi

Laumen

Spiliopoulos³

et al. 2013

BioMedical Engineering OnLine

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BackgroundGood anatomical compatibility is an important aspect in the development of cardiovascular implants. This work analyzes the interaction of the pump unit of an electrically driven pulsatile Total Artificial Heart (TAH) and the mediastinum. For an adequate compliance, both overall dimensions and alignment of inlets and outlets must be matched.MethodsCross-sectional medical image data of 27 individuals, including male and female patients suffering from end stage heart failure, was segmented and reconstructed to three dimensional (3D) surface models. Dimensions and orientations of relevant structures were identified and analyzed. The TAH surface model was virtually placed in orthotopic position and aligned with atrioventricular valves and big vessels. Additionally seven conventional cadaver studies were performed to validate different pump chamber designs based on virtual findings. Thereby 3D-coordinates were captured and introduced to the virtual environment to allow quantitative comparison between different individuals.ResultsSpatial parameters varied more in male patients with higher values if heart failure persists. Good correlation of the virtual analysis both to literature data and conventional cadaver studies could be shown. The full data of the 27 individuals as well as the summarized values found in literature are enclosed in the appendix. By superimposing the TAH-volume model to the anatomy, various misalignments were found and the TAH-design was adjusted.ConclusionsVirtual fitting allows implant design adjustments in realistic anatomy which has not been influenced by thoracotomy. Higher numbers of relevant individuals can be reasonably investigated in the virtual environment and quantitatively correlated. Using this approach, conventional cadaver studies can be significantly reduced but not obviated, due to the unavailable haptic feedback and immobility of potentially compressed structures.

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Section: Resultsmentioning

confidence: 98%

Image based evaluation of mediastinal constraints for the development of a pulsatile total artificial heart

Fritschi

Laumen

Spiliopoulos³

et al. 2013

BioMedical Engineering OnLine

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“…It is designed to function maintenance-free for at least 5 years. The four pole, one phase, voice-coil-motor has been specially designed for the force, space, power and weight requirements of this application [6]. A coil bobbin moves inside the magnetic field caused by permanent magnet rings (Fig.…”

Section: Fig 1 Reinheart Tah System A) Pump Unit B) Internal Controlmentioning

confidence: 99%

“…Commonly used sensor systems for the application in a TAH base upon eddy current sensors [4] or Hall sensors [5]. In pulsatile TAHs with hydraulic drives, pressure sensors give feedback for the drive control [6], [7].…”

Section: Introductionmentioning

confidence: 99%

Novel Optical Position Sensing for Miniaturized Applications and Validation in a Total Artificial Heart

Pelletier¹,

Blaszczyk²,

Carstens³

et al. 2016

IEEE Trans. Biomed. Eng.

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“…All bloodcontacting surfaces, including the two blood pumps (stroke volume of 60 ml) and the four trileaflet valves (24-mm internal diameter) are fabricated from polyurethane (Angioflex R , Abiomed Inc, Danvers, MA). An atrial balance chamber is present and allows for the differences in right-and left-sided stroke volumes (27).…”

Section: Total Artificial Hearts (Tah)mentioning

confidence: 99%