The accelerator neutron source for boron neutron capture therapy

Kasatov, D. A.; Koshkarev, Alexey; Kuznetsov, A.; Makarov, A. N.; Ostreinov, Yu.; Shchudlo, Ivan; Sorokin, Igor; Sycheva, T. V.; Taskaev, S. Yu.; Zaidi, L.

doi:10.1088/1742-6596/769/1/012064

Cited by 15 publications

(11 citation statements)

References 4 publications

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“…The source of epithermal neutrons included an electrostatic tandem accelerator with vacuum insulation, a lithium neutron-generating target, and a neutron beam shaping assembly (Bayanov et al 2006;Zaidi et al 2017). Detailed parameters of the neutron-producing accelerator are described previously (Kasatov et al 2016;Zaidi et al 2018). The accelerator is designed to deliver an epithermal neutron beam for clinical use in humans.…”

Section: Irradiation Experimentsmentioning

confidence: 99%

Accelerator-based boron neutron capture therapy for malignant glioma: a pilot neutron irradiation study using boron phenylalanine, sodium borocaptate and liposomal borocaptate with a heterotopic U87 glioblastoma model in SCID mice

Zavjalov

Zaboronok

Kanygin

et al. 2020

International Journal of Radiation Biology

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Section: Irradiation Experimentsmentioning

confidence: 99%

Accelerator-based boron neutron capture therapy for malignant glioma: a pilot neutron irradiation study using boron phenylalanine, sodium borocaptate and liposomal borocaptate with a heterotopic U87 glioblastoma model in SCID mice

Zavjalov

Zaboronok

Kanygin

et al. 2020

International Journal of Radiation Biology

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“…Boron Neutron Capture Therapy (BNCT) utilizing 10 B(n, α) 7 Li reactions [1] is one of the advanced methods of cancer radiation therapy. At first, BNCT was realized by using fission reactors [2][3][4], but more recently, BNCT using an accelerator-based neutron source [5][6][7][8] has been initiated, which can be installed inside or adjacent to areas of hospitals.…”

Section: Introductionmentioning

confidence: 99%

“…Several types of accelerators such as an electrostatic accelerator [5], a cyclotron [6], and an RFQ linac [7] are candidates for the neutron source for BNCT. Moreover, nuclear reactions such as 7 Li(p,n) 7 B, 9 Be(p,n) 9 B, 7 Li(d,n) 8 Be, and 9 Be(d,n) 10 B are the candidates of the neutron production reaction.…”

Section: Introductionmentioning

confidence: 99%

Neutronics Analyses of the Radiation Field at the Accelerator-Based Neutron Source of Nagoya University for the BNCT Study

Nishitani

Yoshihashi

Tanagami

et al. 2022

JNE

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The Nagoya University Accelerator-driven Neutron Source (NUANS) is an accelerator-based neutron source by 7Li(p,n)7Be reaction with a 2.8 MeV proton beam up to 15 mA. The fast neutrons are moderated and shaped to beam with a Beam Shaping Assembly (BSA). NUANS is aiming at the basic study of the Boron Neutron Capture Therapy (BNCT) such as an in vitro cell-based irradiation experiment using a water phantom. Moreover, the BSA is developed as a prototype of one for human treatment. We have evaluated the radiation field of NUANS by a Monte Carlo code PHITS. It is confirmed that the radiation characteristics at the BNCT outlet meet the requirement of IAEA TECDOC-1223. Additionally, the radiation field in the water phantom located just in front of the BSA outlet is calculated. In the in vitro irradiation experiment, the boron dose of 30 Gy-eq, which is the dose to kill tumor cells, is expected for 20 min of irradiation at the beam current of 15 mA.

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“…Resultingly, accelerator-based (AB) neutron source systems have been developed in many countries, and various types of accelerators, target materials, moderator systems, and irradiation systems have been considered. [1][2][3][4][5][6][7] Unlike other modalities of radiation therapy, it is important to keep the distance between the collimator and the patient as short as possible to reduce the treatment time. The patient setting systems for BNCT installed in the Kansai BNCT Medical Center at the Osaka Medical and Pharmaceutical University are for lying or sitting positions, mainly used for the brain or head and neck regions, respectively.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive evaluation of dosimetric impact against position errors in accelerator‐based BNCT under different treatment parameter settings

Kakino

Isohashi

et al. 2022

Medical Physics

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Background Patients who undergo accelerator‐based (AB) boron neutron capture therapy (BNCT) for head and neck cancer in the sitting position are generally uncomfortably immobilized, and patient motion during this treatment may be greater than that in other radiotherapy techniques. Furthermore, the treatment time of BNCT is relatively long (up to approximately 1 h), which increases the possibility of patient movement during treatment. As most BNCT irradiations are performed in a single fraction, the dosimetric error due to patient motion is of greater consequence and needs to be evaluated and accounted for. Several treatment parameters are required for BNCT dose calculation. Purpose To investigate the dosimetric impacts (DIs) against position errors using a simple cylindrical phantom for an AB‐BNCT system under different treatment parameter settings. Methods The treatment plans were created in RayStation and the dose calculation was performed using the NeuCure® dose engine. A cylindrical phantom (16 cm diameter × 20 cm height) made of soft tissue was modeled. Dummy tumors in the form of a 3‐cm‐diameter sphere were arranged at depths of 2.5 and 6.5 cm (denoted by T2.5 and T6.5, respectively). Reference plans were created by setting the following parameters: collimator size = 10, 12, or 15 cm in diameter, collimator‐to‐surface distance (CSD) = 4.0 or 8.0 cm, tumor‐to‐blood ratio (T/B ratio) using 18F‐fluoro‐borono‐phenylalanine = 2.5 or 5.0, and 10B concentration in blood = 20, 25, or 30 ppm. The prescribed dose was D95% ≥ 20 Gy‐eq for both T2.5 and T6.5. Based on the reference plans, phantom‐shifted plans were created in 26 directions [all combinations of left–right (LR), anterior–posterior (AP), and superior–inferior (SI) directions) and three distances (1.0, 2.0, and 3.0 cm). The DIs were evaluated at D80% of the tumors. The shift direction dependency of the DI in the LR, AP, and SI directions was evaluated by conducting a multiple regression analysis (MRA) and other analyses where required. Results The coefficients of the MRA of the DIs for LR, AP, and SI shifts were −0.08, 2.16, and −0.04 (p‐values = 0.084, <0.01, and 0.334) for T2.5 and −0.05, 2.08, and 0.15 (p‐values = 0.526, <0.01, and 0.065) for T6.5, respectively. The analysis of variance showed that DIs due to the AP shift were significantly greater for smaller collimator sizes on T2.5 and smaller CSD on T6.5. Dose reduction due to SI or LR (lateral) shifts was significantly greater for smaller collimator sizes on both T2.5 and T6.5 and smaller CSD on T2.5, according to the Student's t‐test. There were no significant differences in the DIs against both the AP shift and the lateral shift between the different T/B ratios and 10B concentrations. Conclusion The DIs were largely affected by the shift in the AP direction and were influenced by the different treatment parameters.

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The accelerator neutron source for boron neutron capture therapy

Cited by 15 publications

References 4 publications

Accelerator-based boron neutron capture therapy for malignant glioma: a pilot neutron irradiation study using boron phenylalanine, sodium borocaptate and liposomal borocaptate with a heterotopic U87 glioblastoma model in SCID mice

Accelerator-based boron neutron capture therapy for malignant glioma: a pilot neutron irradiation study using boron phenylalanine, sodium borocaptate and liposomal borocaptate with a heterotopic U87 glioblastoma model in SCID mice

Neutronics Analyses of the Radiation Field at the Accelerator-Based Neutron Source of Nagoya University for the BNCT Study

Comprehensive evaluation of dosimetric impact against position errors in accelerator‐based BNCT under different treatment parameter settings

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