The accuracy of bone mineral density measurement using dual-energy spectral CT and quantitative CT: a comparative phantom study

Li, X.; Li, J.; Jiao, Xi-Jun; Jia, Xiaoqian; Zhang, X.; Fan, Guijuan; Yang, Jian; Guo, Jianxin

doi:10.1016/j.crad.2019.11.008

Cited by 28 publications

(23 citation statements)

References 15 publications

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“…However, the osteoporosis vs.normal group and the normal vs. abnormal group differed signi cantly from the other two groups, the most likely reason being that the lumbar t-score was unreliable. With increasing age, degenerative manifestations of the lumbar spine, such as osteophytes and vertebral tuberosity sclerosis become more common, as well as scoliosis and aortic calci cation, can lead to elevated spinal BMD [10][11]. Recent studies have shown that different sites of osteophytes have a greater impact on patients' BMD measurements.…”

Section: Discussionmentioning

confidence: 99%

Radiomics Based on Lumbar Spine CT Imaging to Detect Osteoporosis

yang

Yang

Shen

et al. 2022

Preprint

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Purpose:This study aims to explore a radiomics model based on lumbar spine CT imaging for detecting osteoporosis. Method:A retrospective analysis of 170 patients who underwent both CT and dual x-ray absorptiometry (DXA) of the lumbar spine in our hospital.According to the DXA results of these patients, 50 patients were normal, 50 patients had osteopenia, and 70 patients had osteoporosis.A total of 851 radiomic features were extracted from the images of the segmentation images in the lumbar CT imaging and the most significant radiomic features were selected to establish fourclassification models: normal vs osteoporosis , normal vs osteopenia, osteopenia vs osteoporosis，normal vs abnormal patients.The estimated area under the receiver operating characteristic curve（ROC）was used to assess the effectiveness of the classification models. Results :The area under the curve (AUC) was 0.942 (95% CI, 0.919-0.964) and 0.933 (95% CI, 0.896-0.971) for the model of normal vs.osteoporosis in the training and validation cohorts, respectively; 0.738 (95% CI, 0. 683-0.792) and 0.749 (95% CI, 0.663- 0.835) for the model of normal vs. Osteopenia ;0.822 (95% CI, 0.778-0.865) and 0.777 (95% CI, 0.700-0.853) for the model of osteopenia vs. Osteoporosis；0.867(95% CI, 0.833-0.900) and 0.825 (95% CI, 0.768-0.882) for the model of normal vs. abnormal. Conclusion: Radiomics based on lumbar CT imaging has great application value in diagnosing abnormal bone mineral density（BMD）.

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Section: Discussionmentioning

confidence: 99%

Radiomics Based on Lumbar Spine CT Imaging to Detect Osteoporosis

yang

Yang

Shen

et al. 2022

Preprint

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“…A statistical survey has shown that the prevalence of osteoporotic fractures in women over 50 years old in China was 15%, with the prevalence of osteoporosis being significantly high among people over 60 years old, especially among female patients [29,31,32]. In recent years, epidemiological and clinical studies have found that HGB levels are associated with osteoporosis [33,34].…”

Section: Discussionmentioning

confidence: 99%

“…The lumbar spine was scanned with quantitative CT (QCT) method [29]. The subject lay supine on a CT scanning bed, and a standard phantom and blue cushion was placed under the lumbar spine parallel to the body.…”

Section: Bone Mineral Density Examinationmentioning

confidence: 99%

Implications of gender-based variabilities in bone mineral density and hemoglobin levels

Zhou

Liu

Wang

et al. 2021

BMC Musculoskelet Disord

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Background Studies reported that there is a relationship between volumetric bone mineral density (vBMD) and hemoglobin (HGB) in sickle cell anemia, chronic obstructive pulmonary disease, inflammatory bowel disease, and chronic kidney disease, it is not clear whether this association exists in normal populations or different genders. In order to further clarify the relationship between vBMD and HGB, and provide the basis for the diagnosis of related diseases, this study was conducted in the physical examination population. Methods A cross-sectional study was conducted on a health check-up population from Wannan area of China from January to December 2018. The study involved 1238 individuals aged 23 to 85 years. Linear regression analysis and smooth curve were applied to determine the relationship of HGB and vBMD. Results The average level of vBMD in the population was 130.11 ± 79.51 mg/cm3, after adjusting for age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglycerides (TG), glucose (GLU), high-density lipoprotein (HDL) and low-density lipoprotein (LDL). A U-shape relationship was established between vBMD and HGB, the cut off value of HGB was 130 g/L. After gender stratification, the results showed a U-shaped curve relationship between vBMD and HGB in male group, and a linear relationship between vBMD and HGB in female group. The vBMD decreased with HGB when HGB < 120 g/L, and increased when HGB ≥ 120 g/L in male group. Conclusion The relationship between vBMD and HGB in the male physical examination population presents a U-shaped curve.

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“…Li et al (24) showed that the measurement error of DECT was less than that of QCT in a phantom study. Our study showed that the RMSE of DECT was smaller than that of QCT, with L1 vertebrae being more significant, suggesting that when osteoporosis is present, the accuracy of BMD measured by DECT is higher than the BMD measured by QCT and is relatively less affected by TAT.…”

Section: Measurement Differences Between Dect and Qct And Correction ...mentioning

confidence: 98%

“…Cui et al (23) showed that the Revolution DECT, with a 0.8 s/r tube speed and a 230-mA tube current as imaging parameters, and the employment of HAP-water base material pair to measure BMD can further ensure the accuracy of the measurement. Li et al (24) demonstrated that both QCT and DECT can accurately measure BMD by scanning ESP. This study showed that the RMSE of both DECT and QCT measurements for each vertebra was the smallest when TAT =0 cm²; that is, when no adipose tissue was wrapped around the phantom.…”

Section: Current Status Of Application Of Bmd Measurement By Dect And...mentioning

confidence: 99%

Effect of abdominal adipose content on spine phantom bone mineral density measured by rapid kilovoltage-switching dual-energy CT and quantitative CT

Ye¹,

Li²,

Yao³

et al. 2022

Quant Imaging Med Surg

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The accuracy of bone mineral density measurement using dual-energy spectral CT and quantitative CT: a comparative phantom study

Cited by 28 publications

References 15 publications

Radiomics Based on Lumbar Spine CT Imaging to Detect Osteoporosis

Radiomics Based on Lumbar Spine CT Imaging to Detect Osteoporosis

Implications of gender-based variabilities in bone mineral density and hemoglobin levels

Effect of abdominal adipose content on spine phantom bone mineral density measured by rapid kilovoltage-switching dual-energy CT and quantitative CT

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