The accuracy of frozen section (intraoperative consultation) in the diagnosis of ovarian masses

İlvan, Şennur; Ramazanoğlu, Rana; Akyıldız, Elif Ülker; Calay, Zerrin; Beşe, Tugan; Oruç, Nafi

doi:10.1016/j.ygyno.2005.01.037

Cited by 95 publications

(78 citation statements)

References 19 publications

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“…The pathologist of other sections may not be familiar with diagnostic clues and FS may become difficult. In spite of these disadvantages overall diagnostic accuracy of FS was reported to be reliable in large series ranging from 84.25% to 97.1%, which was 96.5% in our study (1,(3)(4)(5)(6)(7). We think that attendance of the gynecopathologist to gross examination is a very important factor to increase the diagnostic accuracy of FS.…”

Section: Discussionmentioning

confidence: 47%

Intraoperative frozen section in ovarian neoplasms; a tertiary center experience

Acikalin

Torun²,

Bağır³

et al. 2014

TJPATH

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Objective: Frozen section is an accurate diagnostic tool with some unavoidable pitfalls in gynecologic tumors. We aimed to evaluate the diagnostic value of frozen section, and to detect the factors causing erroneous diagnosis in ovarian tumors. Material and Method:Frozen section and paraffin section reports of 282 patients with ovarian neoplasms diagnosed between July 2006 and January 2013 in our institute were re-analyzed. Results were grouped into benign, borderline (for epithelial tumors) and malignant categories and compared between frozen section and paraffin section diagnosis, statistically. Results:Overall diagnostic accuracy of frozen section was 96.5%. Sensitivity of frozen section for benign, borderline and malignant tumors were 97.5%, 95.8%, and 95.6% and the related specificities were 97.5%, 97.6%, and 100%, respectively. We found the lowest positive predictive value in borderline group (79.3%), all of them with mucinous type epithelium. Second frequent discordant tumor type was immature teratoma. Conclusion:Apart from the limitations of frozen section, pathologists should be aware of the pitfalls of technique and tumor types and tend to sample from the solid areas particularly in mucinous tumors and teratomas to avoid inappropriate surgery. Bulgular:Frozen incelemenin genel tanısal doğruluk oranı %96,5 idi. Benign, borderline ve malign tümörler için frozen incelemenin duyarlığı sırasıyla %97,5, %95,8 ve %95,6 idi. Özgüllük ise aynı sırayla, %97,5, %97,6 ve %100 idi. En düşük pozitif prediktif değer borderline grubunda saptandı (%79,3) ve hataya neden olan tüm olgular müsinöz tip epitelyal tümörler idi. Tanı uyumsuzluğu bulunan ikinci tümör grubu ise immatür teratom idi. Sonuç:Frozen incelemenin kısıtlılıkları yanısıra, patoloğun frozen incelemenin teknik veya tümör tipi ile ilgili tuzaklarını bilmesi, özel-likle müsinöz tümörler ve teratom olgularında solid görünen alanlardan örneklenmesi yetersiz veya gereksiz operasyon yapılmasını önlemek adına yararlı olacaktır.

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Section: Discussionmentioning

confidence: 47%

Intraoperative frozen section in ovarian neoplasms; a tertiary center experience

Acikalin

Torun²,

Bağır³

et al. 2014

TJPATH

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“…at our institute borderline tumors were treated like malignant. In our study on 30 patients sensitivity for borderline tumors was 60%.studies report sensitivity between 0 to 88.7% [14,15,16,17,18] . 2 cases out 5 borderline diagnosed by frozen section, turned out to be malignant on histopathology.…”

Section: Discussionsupporting

confidence: 43%

Role of Frozen Section in the Intra operative management of Ovarian Neoplasms and Comparing with Final Histopathological Diagnosis – A Prospective Study

Maheshwari¹

2017

jmscr

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“…The diagnosis of borderline ovarian tumor in older age group will lead the surgeon to do hysterectomy, bilateral salpingo-opherectomy and surgical staging. With the same diagnosis in reproductive age group, where the incidence of borderline tumors are high, the surgical management is fertility conserving surgery-unilateral salpingo-oopherectomy or even cystectomy with surgical staging [9].…”

Section: Discussionmentioning

confidence: 99%

Role of Frozen Section in Intraoperative Assessment of Ovarian Masses: a Tertiary Oncology Center Experience.

Sukumaran

Somanathan

Mathews

et al. 2014

Indian J Surg Oncol

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Surgical management of ovarian lesions vary considerably depending on the nature of the lesion. As the preoperative imaging and serum tumor marker levels are of limited value in the proper categorization of ovarian lesions, intraoperative pathological assessment is commonly requested for a primary diagnosis. Aim of the study is to assess the accuracy of the frozen section in the diagnosis of ovarian masses in our center and to analyze the causes of diagnostic discrepancies. In this retrospective study, frozen section diagnosis of 233 cases of ovarian masses was compared with the permanent section diagnosis. The overall accuracy of frozen section was 91.85 %. The sensitivity of frozen section diagnosis for benign, borderline and malignant tumors was 99.2, 88.46 and 82.95 % respectively. The corresponding specificity was 96.5, 93.23 and 99.3 %. There were 19 discordant cases including 18 false negative cases and one false positive case. Frozen section is an important diagnostic tool to determine the nature of ovarian masses. Careful macroscopic examination, evaluation of multiple sections along with clinical and radiological findings helps to reduce false positive and false negative results. Frozen section examination has limitations especially in cases of borderline tumors. This modality is most effective when the pathologist and surgeon are aware of the advantages and limitations.

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The accuracy of frozen section (intraoperative consultation) in the diagnosis of ovarian masses

Cited by 95 publications

References 19 publications

Intraoperative frozen section in ovarian neoplasms; a tertiary center experience

Intraoperative frozen section in ovarian neoplasms; a tertiary center experience

Role of Frozen Section in the Intra operative management of Ovarian Neoplasms and Comparing with Final Histopathological Diagnosis – A Prospective Study

Role of Frozen Section in Intraoperative Assessment of Ovarian Masses: a Tertiary Oncology Center Experience.

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