The accuracy of lamellar body count and lecithin/sphingomyelin ratio in the prediction of neonatal respiratory distress syndrome: a meta‐analysis

Abstract

Objective To compare the performance of the lecithin/sphingomyelin ratio and the lamellar body count in the prediction of neonatal respiratory distress syndrome. Design Meta-analysis.Sample Six studies reporting on the performance of both the lecithin/sphingomyelin ratio and the lamellar body count published between January 1966 and August 1999.Methods We performed a computerised MEDLINE search to identify articles published on the subject. For the six selected studies, prevalence of respiratory distress syndrome and sensitivity and speci®city of the tests in the prediction of respiratory distress syndrome were calculated, and overall performance was assessed by constructing summary receiver±operating characteristic curves. Results The constructed summary receiver±operating characteristic curves showed the lamellar body count to perform slightly better than the lecithin/sphingomyelin ratio in the prediction of respiratory distress syndrome (P 0.13).Conclusions Since the lamellar body count can be performed quickly and since it is less expensive than the lecithin/sphingomyelin ratio, we recommend the former as the test of ®rst choice in the assessment of fetal lung maturity.

Prenatal prediction of neonatal respiratory morbidity: a radiomics method based on imbalanced few-shot fetal lung ultrasound images

“…First, to the best of our knowledge, this is the first study to incorporate GDM, GA, and radiomics features for NRM prenatal prediction. The diagnostic efficacy of the model we developed based on fetal lung ultrasound images in this study reached which are similar to those of many previous reports of amniocentesis [ 26 – 28 ]. Second, we developed a practical modelling approach to address the problems of imbalance and few-shot.…”

Neonatal morbidity after documented fetal lung maturity in late preterm and early term infants

“…Several studies have documented low- and high-risk ranges of RDS that do not agree. 18–21 Although multiple studies state that each institution should validate its own standards according to the methods used, 20,22 we recognized that the inclusion of LBC as a test for fetal lung maturity, with our hospital laboratory cutoff of >29,000 per μ L, might be interpreted as a weakness of the study. Thus, we stratified our analysis in the basis of the specific lung maturity test that was used.…”