The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration

Gurniak, Christine B.; Perlas, Emerald; Witke, Walter

doi:10.1016/j.ydbio.2004.11.010

Cited by 207 publications

(217 citation statements)

References 40 publications

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“…Cofilins localize to the regions of rapid actin dynamics, and their most important physiological function is to depolymerize filaments from their pointed ends, thereby increasing actin dynamics (21). Complete lack of neural tube closure was observed in the case of Cfl-1 mutant embryos (26). Our recent work indicated that TFII-I is critical in the neural tube closure event (D.B., unpublished results).…”

Section: Rattus Norvegicusmentioning

confidence: 93%

Identification of the TFII-I family target genes in the vertebrate genome

Chimge

Makeyev

Ruddle

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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GTF2I and GTF2IRD1 encode members of the TFII-I transcription factor family and are prime candidates in the Williams syndrome, a complex neurodevelopmental disorder. Our previous expression microarray studies implicated TFII-I proteins in the regulation of a number of genes critical in various aspects of cell physiology. Here, we combined bioinformatics and microarray results to identify TFII-I downstream targets in the vertebrate genome. These results were validated by chromatin immunoprecipitation and siRNA analysis. The collected evidence revealed the complexity of TFII-Imediated processes that involve distinct regulatory networks. Altogether, these results lead to a better understanding of specific molecular events, some of which may be responsible for the Williams syndrome phenotype.GTF2I ͉ Williams-Beuren syndrome

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Section: Rattus Norvegicusmentioning

confidence: 93%

Identification of the TFII-I family target genes in the vertebrate genome

Chimge

Makeyev

Ruddle

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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“…Although mutant mice that lack cofilin 1 (the non-muscle isoform) are indistinguishable in their gross morphology from control mice embryos at E9.5, no embryos were found at term, suggesting that cofilin 1 mutants are embryonic lethal 60 . Before stage E9.5, cofilin might not be essential for the extensive morphogenetic movements during gastrulation, raising the possibility that additional cofilin isoforms such as ADF might compensate in this type of cell migration, as evidenced by a threefoldfourfold overexpression of the cofilin isoform ADF compared with that in wild-type control embryos.…”

Section: Box 2 Linking Cofilin To Drosophila Melanogaster Morphogenesismentioning

confidence: 99%

The cofilin pathway in breast cancer invasion and metastasis

Wang¹,

2007

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Recent evidence indicates that metastatic capacity is an inherent feature of breast tumours and not a rare, late acquired event. This has led to new models of metastasis. The interpretation of expression-profiling data in the context of these new models has identified the cofilin pathway as a major determinant of metastasis. Recent studies indicate that the overall activity of the cofilin pathway, and not that of any single gene within the pathway, determines the invasive and metastatic phenotype of tumour cells. These results predict that inhibitors directed at the output of the cofilin pathway will have therapeutic benefit in combating metastasis.Tumour cell motility is the hallmark of invasion and an essential step in metastasis 1,2 . The identification of molecular pathways that contribute to tumour cell motility and invasion is essential for understanding how motility is initiated in tumour cells and how the tumour microenvironment contributes to cell migration. The identification of the molecular pathways of tumour cell invasion will provide new diagnostic approaches and targets for the treatment of metastatic cancer. Recent studies using new technologies, including highdensity microarray-based expression profiling, intravital imaging and the collection of invasive tumour cells from live tumours, have started to extend the traditional model of metastasis and supply new diagnostic and therapeutic markers of metastatic disease.According to the traditional model of metastasis, metastases result from a process similar to Darwinian evolution whereby natural selection works on individual tumour cells to select © 2007 Nature Publishing Group Correspondence to: J.C. Condeeli@aecom.yu.edu. Competing interests statementThe authors declare no competing financial interests. for stable genetic changes. The cells so selected are very rare, and the metastatic cells that arise from this progressive selection of stable genetic mutations within the primary tumour cause metastasis late in tumour progression 3 . However, studies of mammary tumours in mice [4][5][6][7] , expression profiling of both whole human breast tumours 8,9 and the invasive subpopulation of tumour cells isolated from rat and mouse mammary tumours [10][11][12] suggest that the metastatic ability of breast tumours is encoded throughout the bulk of the primary tumour, involves transient changes in gene expression and is acquired at much earlier stages of tumour progression than postulated by the traditional model. These results suggest that a Darwinian-like evolution is accompanied by, and may contribute to, microenvironmentinduced transient changes in gene expression that support the invasive and metastatic phenotype. These results have led to new models where the microenvironment initiates the expression of genes that induce cell motility, invasion and metastasis 11,13 . In the 'tumour microenvironment invasion model' it is proposed that oncogenic mutations in tumour cells lead to microenvironments that are potentially encoded throughout the b...

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“…ADFs are part of the ADF/cofilin group of small (15~22 kDa) actinbinding proteins that include cofilin, destrin, depactin, and actophorin and are ubiquitous in all eukaryotes (Carlier, 1998;Yeoh et al, 2002). They are essential for cell viability, playing critical roles in accelerating actin filament turnover during cell locomotion, cytokinesis, and other forms of cell motility (Yeoh et al, 2002;Gurniak et al, 2005). Mutants have been characterized in several organisms and are associated with lethality, arrest in cell proliferation, and a disorganized actin cytoskeleton (Gunsalus et al, 1995).…”

Section: Cellular Immune Proteinsmentioning

confidence: 99%

Proteome changes in the plasma of Papilio xuthus (Lepidoptera: Papilionidae): effect of parasitization by the endoparasitic wasp Pteromalus puparum (Hymenoptera: Pteromalidae)

Zhu

Yè

Fang

et al. 2009

J. Zhejiang Univ. Sci. B

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Abstract:Although the biochemical dissection of parasitoid-host interactions is becoming well characterized, the molecular knowledge concerning them is minimal. In order to understand the molecular bases of the host immune response to parasitoid attack, we explored the response of Papilio xuthus parasitized by the endoparasitic wasp Pteromalus puparum using proteomic approach. By examining the differential expression of plasma proteins in the parasitized and unparasitized host pupae by two-dimensional (2D) electrophoresis, 16 proteins were found to vary in relation to parasitization compared with unparasitized control samples. All of them were submitted to identification by mass spectrometry coupled with a database search. The modulated proteins were found to fall into the following functional groups: humoral or cellular immunity, detoxification, energy metabolism, and others. This study contributes insights into the molecular mechanism of the relationships between parasitoids and their host insects.

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The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration

Cited by 207 publications

References 40 publications

Identification of the TFII-I family target genes in the vertebrate genome

Identification of the TFII-I family target genes in the vertebrate genome

The cofilin pathway in breast cancer invasion and metastasis

Proteome changes in the plasma of Papilio xuthus (Lepidoptera: Papilionidae): effect of parasitization by the endoparasitic wasp Pteromalus puparum (Hymenoptera: Pteromalidae)

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