The Action of Anesthesia on the Histamine Release in Anaphylactic Shock

Abstract

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

Inhibition of the anaphylactic reaction

“…With regard to mechanism it has been found that the antigen-antibody reaction can be separated from histamine release. This confirms the work of Katz (1940) with anaesthetics. Further analysis of the inhibitory action of phenol revealed two points of special interest.…”

“…With regard to mechanism it has been found that the antigen-antibody reaction can be separated from histamine release. This confirms the work of Katz (1940) These findings may be examined in the light of two theories which in one form or another have long influenced discussion on the mechanism of anaphylaxis. These theories, which are not necessarily exclusive but may be complementary, will be referred to as the 'aggregation theory' and the 'enzymic theory' of anaphylaxis.…”

“…There is evidence that some inhibitors of plain muscle interfere with the release of histamine and in this way block yet another stage ofthe anaphylactic reaction, e.g. both adrenaline (Schild, 1936) and ether (Katz, 1940) inhibit the release of histamine from guinea-pig lungs in anaphylaxis. Salicylates also inhibit histamine release (Trethewie, 1951;Haining, 1956).…”